Cancer
Tumor necrosis factor alpha gene -308G>A polymorphism association with the risk of esophageal cancer in a Han Chinese population
Authors: H. Zhao, H.W. Zhang, T. Zhang and X.M. Gu
ABSTRACT. In the present study, we aimed to investigate the association between the TNF-α -308G>A polymorphism and the risk of esophageal cancer in a Han Chinese population. The case group included 342 patients with esophageal cancer and the control group comprised 300 healthy individuals. The TNF-α -308G>A p.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15025866
- DOI:
- 10.4238/gmr.15025866
Association between the pre-miR-196a2 rs11614913 polymorphism and gastric cancer susceptibility in a Chinese population
Authors: M. Li, R.J. Li, H. Bai, P. Xiao, G.J. Liu, Y.W. Guo and J.Z. Mei
We did a case-control study to provide a more comprehensive evaluation of the association of the pre-miR-196a2 rs11614913 polymorphism with gastric cancer. Between January 2013 and December 2014, 182 patients newly diagnosed with primary gastric cancer and 182 control subjects were recruited at Zhengzhou People’s Hospita.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027516
- DOI:
- 10.4238/gmr.15027516
Roles of functional NFKB1 and �²-TrCP insertion/deletion polymorphisms in mRNA expression and epithelial ovarian cancer susceptibility
Authors: Z.H. Huo, H.J. Zhong, Y.S. Zhu, B. Xing and H. Tang
Epithelial ovarian cancer (EOC) is the leading cause of death among all gynecological cancers. Nuclear factor-kappa B (NF-κB) is involved in carcinogenesis and in the development of EOC. The β-transducin repeat-containing protein (β-TrCP) is a positive regulator of the NF-κB signaling pathway. Recent studies have indicated that the -.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.11.6
- DOI:
- 10.4238/2013.March.11.6
Polymorphisms in promoter regions of IL-6 and IL-10 genes in breast cancer: a case-control study
Authors: E.S. AlSuhaibani, N.A. Kizilbash, S. Malik, J.I. Dasti, F. Al Beladi and N. El-Morshedi
Polymorphisms in interleukin genes (IL-6 and IL-10) are involved in the pathogenesis of breast cancer. This study investigated polymorphisms in the promoter regions of IL-6 (-174G/C) and IL-10 (-1082G/A) through a case-control study employing 80 female subjects who were pathologically diagnosed with breast cancer. All patients received follow-up care at t.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017360
- DOI:
- 10.4238/gmr.15017360
Relationship between multidrug resistance 1 polymorphisms and the risk of prostate cancer in Chinese populations
Authors: F.R. Shen , C.Y. Yan, M. Liu, Y.H. Feng and Y.G. Chen
Prostate cancer is one of the most common malignancies in men. The multidrug resistance 1 gene (MDR1) is an important candidate gene for prostate cancer. The aim of this study was to evaluate the association between MDR1 gene polymorphisms and the risk of prostate cancer. MDR1 gene polymorphism and its association with the risk of prostate cancer were inv.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.12
- DOI:
- 10.4238/2013.September.19.12
Clinical value of concurrent radiochemotherapy in cervical cancer and comparison of ultrasonography findings before and after radiochemotherapy
Authors: W.M. Yan,X.Z. Li,Z.L. Yu,J. Zhang and X.G. Sun
Herein, we investigated the clinical value of concurrent radiochemotherapy for patients with advanced cervical cancer and its effects on adverse clinical symptoms. Forty patients with cervical cancer were recruited from January 2011 to January 2014 for this study. Participants were randomly allocated into a test or control group, with 20 patients in each .. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.13
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.13
DNMT3A -448A>G polymorphism and cancer risk: a meta-analysis
Authors: C.H. Liu,T. Tao1,L. Jiang1,B. Xu,L. Zhang, K. Lu,X.W. Zhang,S.Q. Chen,D.C. Liu and M. Chen
Cancer is a major public health problem worldwide that involves complex processes and factors. For instance, methylation is important in tumorigenesis. DNA (cytosine-5)-methyltransferase 3A (DNMT3A) is the main de novo methyltransferase implicated in this process. In DNMT3A, the -448A>G polymorphism is associated with cancer; however, the results of va.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.14
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.14
Polymorphisms in GSTM1, GSTT1, GSTP1, and GSTM3 genes and breast cancer risk in northeastern Mexico
Authors: G. Jaramillo-Rangel, M. Ortega-MartÃ?Ânez, R.M. Cerda-Flores andH.A. Barrera-SaldaÃ?±a
Glutathione S-transferases (GSTs) are a family of phase II metabolizing enzymes involved in carcinogen detoxification and the metabolism of various bioactive compounds. Several genes that code for these enzymes are polymorphic in an ethnicity-dependent manner, with particular genotypes previously associated with an increased risk of breast cancer. The pur.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.11.22
- DOI:
- 10.4238/2015.June.11.22
BK polyomavirus association with colorectal cancer development
Authors: M.N. Khabaz, T. Nedjadi, M.A. Gari, J.A. Al-Maghrabi, H.M. Atta, A.A. Basuni and D.A. Elderwi
The development of human neoplasms can be provoked by exposure to one of several viruses. Burkitt lymphoma, cervical carcinoma, and hepatocellular carcinoma are associated with Epstein-Barr, human papilloma, and hepatitis B virus infections, respectively. Over the past three decades, many studies have attempted to establish an.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027841
- DOI:
- 10.4238/gmr.15027841
Comparison of the expression of human equilibrative nucleotide transporter 1 (hENT1) and ribonucleotide reductase subunit M1 (RRM1) genes in seven non-Hodgkin lymphoma cell lines
Authors: H.B. Zhao, X.F. Zhang, F. Shi, M.Z. Zhang and W.L. Xue
We investigated the variability in the expression of human equilibrative nucleoside transporter 1 (hENT1) and ribonucleotide reductase subunit M1 (RRM1) in non-Hodgkin lymphoma cell lines. hENT1 and RRM1 mRNA expression levels in natural killer (NK) cells and seven non-Hodgkin lymphoma cell lines (YTS, SNK-6, Jeko-1, ly-1, Raj.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028275
- DOI:
- 10.4238/gmr.15028275