Cancer
Association of miR-21 with esophageal cancer prognosis: a meta-analysis
Authors: S.-W. Wen, Y.-F. Zhang, Y. Li, Z.-X. Liu, H.-L. Lv, Z.-H. Li, Y.-Z. Xu, Y.-G. Zhu and Z.-Q. Tian
The present study aimed to explore the relationship between miRNA expression and survival in patients with esophageal cancer (EC) using meta-analysis. We searched PubMed, EMBASE, CNKI, Wanfang, and ISI Web of Science databases without time restrictions, and extracted relevant data, such as the name of first author, publication year, age, gender, number of.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.12.12
- DOI:
- 10.4238/2015.June.12.12
Recombinant adenovirus-mediated overexpression of PTEN and KRT10 improves cisplatin resistance of ovarian cancer in vitro and in vivo
Authors: H. Wu, K. Wang, W. Liu and Q. Hao
Drug resistance is a major cause of treatment failure in ovarian cancer patients, and novel therapeutic strategies are urgently needed. Overexpression of phosphatase and tensin homolog (PTEN) has been shown to preserve the cisplatin-resistance of ovarian cancer cells, while cisplatin-induced keratin 10 (KRT10) overexpression mediates the resistance-revers.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.1
- DOI:
- 10.4238/2015.June.18.1
NDC80 promotes proliferation and metastasis of colon cancer cells
Authors: X.K. Xing, H.Y. Wu, H.L. Chen and H.G. Feng
Chromosome instability is a common feature of tumor cells, and may be an important mechanism in tumor formation. Nuclear division cycle 80 (NDC80) is closely associated with the stability of chromosomes. Therefore, we investigated the relationship between NDC80 and development of colon cancer using a range of methods. Western .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028312
- DOI:
- 10.4238/gmr.15028312
Role of MTHFR C677T and MTR A2756G polymorphisms in thyroid and breast cancer development
Authors: T. Zara-Lopes, A.P.A. Gimenez-Martins, C.H.V. Nascimento-Filho, M.M.U. Castanhole-Nunes, A.L.S. Galbiatti-Dias, J.A. Padovani-J�ºnior, J.V. Maniglia, J.L.E. Francisco, E.C. Pavarino and E.M. Goloni-Bertollo
Folate metabolism is essential for DNA synthesis and repair. Alterations in genes that participate in folate metabolism can be associated with several types of malignant neoplasms, including thyroid and breast cancer. In the present case-control study, we examined the association between methylenetetrahydrofolate reductase (MT.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028222
- DOI:
- 10.4238/gmr.15028222
MicroRNA-154 functions as a tumor suppressor and directly targets HMGA2 in human non-small cell lung cancer
Authors: H.C. Zhuo, Y.F. Song, J. Ye, G.X. Lai and D.L. Liu
MicroRNA-154 (miR-154) is dysregulated in some human malignancies and is correlated with tumor progression. However, its expression and function in non-small cell lung cancer (NSCLC) remain unclear. Therefore, we explored the effects of miR-154 on NSCLC tumorigenesis and development. Using quantitative reverse transcription-po.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028173
- DOI:
- 10.4238/gmr.15028173
Molecular docking of the anticancer bioactive compound proceraside with macromolecules involved in the cell cycle and DNA replication
Authors: A.B. Gurung, M.A. Ali, A. Bhattacharjee, M. AbulFarah, F. Al-Hemaid, F.M. Abou-Tarboush, K.M. Al-Anazi, F.S.M. Al-Anazi and J. Lee
The bioactive compounds proceraside A, frugoside and calotropin, which were extracted from the root bark of Calotropis procera (Aiton) W.T. Aiton (family Asclepiadaceae), were recently reported to inhibit the growth of inhibition against various human cancer cell lines in vitro. However, their modes of action have not been cle.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027829
- DOI:
- 10.4238/gmr.15027829
Association between the expression of HIF-1�± and VEGF and prognostic implications in primary liver cancer
Authors: L.Y. Guo, P. Zhu and X.P. Jin
The goal of this study was to investigate the expression of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in primary liver cancer (PLC) and their association with prognosis. Tumor tissue, non-tumor tissue, and blood samples of 75 PLC patients were collected. Blood samples of 20 .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028107
- DOI:
- 10.4238/gmr.15028107
Effect of overexpression of PTEN on apoptosis of liver cancer cells
Authors: M.F. Li, H. Guan and D.D. Zhang
Liver cancer is a common malignant tumor associated with a short-survival period and high-mortality rate, and its prevalence in China is particularly high. This study aimed to investigate the effect of overexpressing the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene on liver cancer cell apoptosis and prov.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028120
- DOI:
- 10.4238/gmr.15028120
Expression and clinical significance of Kelch-like epichlorohydrin-associated protein 1 in breast cancer
Authors: L. Zhang, W.P. Yang, L.Y. Wu, X. Zhu and C.Y. Wei
Our objective was to explore the expression and clinical significance of Kelch-like epichlorohydrin-associated protein 1 (Keap1) in breast cancer tissue. Eighty-one breast cancer patients having undergone surgical treatment in our hospital between March 2002 and December 2008 were enrolled in this study. Normal tissue adjacent.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027294
- DOI:
- 10.4238/gmr.15027294
An A/G polymorphism rs3746444 in miR-499 is associated with increased cancer risk: a meta-analysis
Authors: N. Wang, ZQ Tian, Y. Li, R.M. Zhou and G.Y. Wang
An A/G polymorphism (rs3746444) has been identified in the miR-499 gene that can change the conformation of the secondary gene structure and thereby directly affect binding to target mRNAs and the microRNA (miRNA) maturation process, thus altering protein expression and potentially contributing to cancer susceptibility. Numerous studies investigating the .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.14
- DOI:
- 10.4238/2013.September.23.14