Cancer
Investigating the role of polymorphisms in miR-146a, -149, and -196a2 in the development of gastric cancer
Authors: J.Y. Gu and L. Tu
Here, we performed a case-control study to investigate the role of miR-146a, miR-149, and miR-196a2 polymorphisms in the development of gastric cancer using a hospital-based case-control design. A total of 186 gastric cancer patients and 186 control subjects were enrolled from Ren Ji Hospital between January 2012 and October 2.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027839
- DOI:
- 10.4238/gmr.15027839
Effects of siRNA-mediated silencing of Sal-like 4 expression on proliferation and apoptosis of prostate cancer C4-2 cells
Authors: K.F. Liu and Y.X. Shan
The aim of this study was to evaluate the effects of small interfering RNA (siRNA)-inhibited expression of the Sal-like 4 (SALL4) gene on the proliferation, colony formation, and apoptosis of prostate cancer C4-2 cells. C4-2 cells were cultured and divided into a si-SALL4 group, a negative control siRNA group, and a blank cont.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027885
- DOI:
- 10.4238/gmr.15027885
Association of the p53 Arg72Pro polymorphism with esophageal cancer in Chinese populations: a meta-analysis
Authors: J.Z. Peng, L. Xue, D.G. Liu and Y.H. Lin
Although many epidemiologic studies have investigated the p53 codon 72 polymorphism and its association with esophageal cancer (EC) in China, definite conclusions could not be drawn. To clarify the effects of p53 codon 72 polymorphism on the risk of EC, we performed a meta-analysis on the Chinese population. A total of 13 studies including 3308 patients a.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.11
- DOI:
- 10.4238/2015.August.7.11
Genetic polymorphisms and haplotype of hormone-related genes are associated with the risk of breast cancer in Chinese women
Authors: Z. Pan, Z. Fu, Q. Song, W. Cao, W. Cheng and X. Xu
Sex hormones play important roles in breast cancer (BC) development. This study investigated associations between BC risk and hormone-related gene variants in Chinese women. In a cohort of 336 patients with histopathologically confirmed BC and 390 age-matched controls, we genotyped seven single nucleotide polymorphisms (SNPs) .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028640
- DOI:
- 10.4238/gmr.15028640
Associations between the SRD5A2 gene V89L and TA repeat polymorphisms and breast cancer risk: a meta-analysis
Authors: D. Zhang, Q. Li, H.-C. Qu, T. Yu and Y.-R. Liu
The 5α-reductase type 2 (SRD5A2) gene plays a significant role in the development of breast cancer. The V89L and TA repeat polymorphisms of the SRD5A2 gene have been considered as risk factors for breast cancer. However, the results have been inconsistent. To resolve this conflict, we performed a meta-analysis of studies with V89L (1144 patients and.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.9
- DOI:
- 10.4238/2015.August.7.9
Inhibitory effect of ursolic acid and oleanolic acid from Eriobotrya fragrans on A549 cell viability in vivo
Authors: Y.S. Gao, Y. Yuan, G. Song and S.Q. Lin
Loquat [Eriobotrya japonica (Lindl.)] is a traditional Chinese medicine, which has been used as an anti-inflammatory and for curing chronic bronchitis among other potential applications. Extracted ursolic acid (UA) and oleanolic acid (OA) from wild loquat were previously found capable of suppressing the proliferation of A549 c.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028642
- DOI:
- 10.4238/gmr.15028642
Models of logistic regression analysis, support vector machine, and back-propagation neural network based on serum tumor markers in colorectal cancer diagnosis
Authors: B. Zhang, X.L. Liang, H.Y. Gao, L.S. Ye and Y.G. Wang
We evaluated the application of three machine learning algorithms, including logistic regression, support vector machine and back-propagation neural network, for diagnosing congenital heart disease and colorectal cancer. By inspecting related serum tumor marker levels in colorectal cancer patients and healthy subjects, early d.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028643
- DOI:
- 10.4238/gmr.15028643
S-phase kinase-associated protein 2 expression interference inhibits breast cancer cell proliferation
Authors: Y.J. Sun, X.K. Wang and B.J. Li
We investigated the expression of S-phase kinase-associated protein 2 (SKP2) in breast cancer tissues, and the effects of SKP2-specific small interfering RNA (siRNA) interference on breast cancer cell proliferation. Thirty subjects provided breast cancer tissue samples and 18 subjects provided normal breast specimens for this study. The expression of SKP2.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.4
- DOI:
- 10.4238/2015.August.10.4
IL-17A and IL-17F polymorphisms and gastric cancer risk: a meta-analysis
Authors: Z. Li, Y. Liu, D. Cao, M. Jiang and F. Luo
We conducted a meta-analysis of eligible studies to estimate the association between gastric cancer risk and rs2275913G>A IL-17A and rs763780T>C IL-17F polymorphisms. We searched the relevant studies in both Chinese and English through PubMed, the Web of Science, the Cochrane Library, and EMBASE up to January 1, 2014, including 3939 cases and 5407 c.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.10
- DOI:
- 10.4238/2015.June.26.10
S-adenosylmethionine, a methyl donor, up regulates tissue inhibitor of metalloproteinase-2 in colorectal cancer
Authors: Z. Hussain, M.I. Khan, M. Shahid and F.N. Almajhdi
DNA methylation is a fundamental epigenetic mechanism in regulating the expression of genes controlling crucial cell functions in cancer development. Gene silencing via CpG island methylation/demethylation in the promoter region is one of the mechanisms by which different genes are inactivated/activated in human cancers. Tissue inhibitor of metalloprotein.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.10.6
- DOI:
- 10.4238/2013.April.10.6