Cancer
Predictive potential role of glutathione S-transferases polymorphisms in response to chemotherapy and breast cancer prognosis
Authors: P. Yuan, L. Yuan, B.L. Xu, C.Z. Wang, H.Z. Yang and Y. Li
The aim of this study was to evaluate the role of GSTM1 null/present, GSTT1 null/present, and GSTP1 polymorphisms in the clinical response to chemotherapy and treatment outcome of breast cancer. The GSTM1, GSTT1, and GSTP1 IIe105Val polymorphism genotypes were analyzed using polymerase chain reaction coupled with restriction fragment length polymorphism. .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.15
- DOI:
- 10.4238/2015.December.11.15
Screening for key genes associated with invasive ductal carcinoma of the breast via microarray data analysis
Authors: J.L. Huan, X. Gao, L. Xing, X.J. Qin, H.X. Qian, Q. Zhou and L. Zhu
The aim of this study was to identify key genes related to invasive ductal carcinoma (IDC) of the breast by analyzing gene expression data with bioinformatic tools. Microarray data set GSE31138 was downloaded from Gene Expression Omnibus, including 3 breast cancer tissue samples and 3 normal controls. Differentially expressed .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.5
- DOI:
- 10.4238/2014.September.29.5
Gene expression profile and enrichment pathways in different stages of bladder cancer
Authors: Z.-Q. Fang, W.-D. Zang, R. Chen, B.-W. Ye, X.-W. Wang, S.-H. Yi, W. Chen, F. He and G. Ye
Bladder cancer is a highly heterogeneous neoplasm. We examined the gene expression profile in 3 bladder cancer stages (Ta, T1, T2) using expression microarray analysis of 40 bladder tumors. Differentially expressed genes were found by the t-test, with <0.005 as the significance threshold. KEGG pathway-enrichment analysis was used to study the signaling.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.6.1
- DOI:
- 10.4238/2013.May.6.1
Blockage of cisplatin-induced autophagy sensitizes cervical cancer cells to cisplatin
Authors: W.M. Lin and Z.G. Li
Development of chemoresistance is a major obstacle that leads to the recurrence and progression of cervical cancer (CC). Autophagy, meaning, “eating of self”, has shown paradoxical functions in tumors. In this study, we first investigated the process of autophagy induction by cisplatin in CC cells. Next, we investigated the role of autophagy i.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.18
- DOI:
- 10.4238/2015.December.14.18
Mutation profile of KRAS and BRAF genes in patients with colorectal cancer: association with morphological and prognostic criteria
Authors: M. Samara, K. Kapatou, M. Ioannou, Ã?Â?. Kostopoulou, R. Papamichali, C. Papandreou, A. Athanasiadis and G. Koukoulis
KRAS and BRAF mutations are well-recognized molecular alterations during colorectal carcinogenesis, but there is little agreement on their effect on tumor characteristics. Therefore, we aimed to evaluate the distribution of the most common KRAS and BRAF mutations in Greek patients with colorectal cancer and their possible associations with clinical histop.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.6
- DOI:
- 10.4238/2015.December.14.6
miR-218 tissue expression level is associated with aggressive progression of gastric cancer
Authors: X.X. Wang, S.J. Ge, X.L. Wang, L.X. Jiang, M.F. Sheng and J.J. Ma
The aim of the present study was to investigate the clinical significance of microRNA-218 (miR-218) in gastric cancer. We enrolled 112 patients having undergone surgery for gastric cancer between May 2008 and June 2014. Expression of miR-218 was determined by real-time quantitative reverse transcription-polymerase chain reacti.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027521
- DOI:
- 10.4238/gmr.15027521
Association between the -607 C > A polymorphism in interleukin-18 gene promoter with gastrointestinal cancer risk: a meta-analysis
Authors: J. Yao, Z.H. Li, Y.X. Li, R. Zhang, D.G. Zhang, Z.L. Xu, L.S. Wang and J.Y. Wang
The interleukin-18 (IL-18) gene -607 C/A polymorphism has been reported to be associated with gastrointestinal cancer, but there are conflicting results from previous studies on said topic. Therefore, the aim of this meta-analysis is to derive a more precise estimation of the association between the -607 C/A polymorphism in the IL-18 gene and gastrointest.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.15
- DOI:
- 10.4238/2015.December.14.15
Association of a let-7 KRAS rs712 polymorphism with the risk of breast cancer
Authors: X. Huang, Y. Yang, Y. Guo, Z.L. Cao, Z.W. Cui, T.C. Hu and L.B. Gao
Breast cancer (BC) is a common malignancy affecting women, with increasing incidences of this disease in China every year. Recent studies have extensively investigated a single nucleotide polymorphism in the let-7 miRNA binding site of the 3'-untranslated region of KRAS mRNA. The aim of this study was to determine the genotype frequency of the KRAS rs712 .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.19
- DOI:
- 10.4238/2015.December.14.19
Correlations between the COMT gene rs4680 polymorphism and susceptibility to ovarian cancer
Authors: W. Pan and H. Liao
The objective of this study was to perform a systematic review of the correlations between the single nucleotide polymorphism rs4680 in the catechol-O-methyltransferase (COMT) gene and susceptibility to ovarian cancer. A computer search was carried out for relevant case-control studies published between January 2000 to January 2014 in databases such as Ov.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.8
- DOI:
- 10.4238/2015.December.14.8
Meta-analysis of the relationship between slow acetylation of N-acetyl transferase 2 and the risk of bladder cancer
Authors: Y. An , H. Li, K.J. Wang, X.H. Liu, M.X. Qiu, Y. Liao, J.L. Huang and X.S. Wang
The incidence of bladder cancer is closely associated with exposure to aromatic amines, that can cause cancer only after metabolic activation regulated by N-acetyl transferase 1 and 2 (NAT1 and NAT2). Many studies have indicated that slow acetylation of NAT2 increases the risk of bladder cancer. The major risk factor is tobacco smoke; however, some studie.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.17
- DOI:
- 10.4238/2015.December.14.17