Cancer
Association of the interleukin-6 gene -572G/C polymorphism with cancer risk: a meta-analysis
Authors: Q. Zhao, B. Zhang, Y. Chen, M. Li, X. Zhao, H. Fan and S.M. Li
The -572G/C polymorphism in interleukin-6 (IL-6) gene is associated with the development of cancer. However, previous studies have shown conflicting results; therefore, the association must be verified by an appropriate meta-analysis. For this purpose, we performed a literature search of the PubMed database to identify all reports on association between t.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.20
- DOI:
- 10.4238/2015.December.14.20
Serum levels of PSA, ALP, ICTP, and BSP in prostate cancer patients and the significance of ROC curve in the diagnosis of prostate cancer bone metastases
Authors: R.J. Wei, T.Y. Li, X.C. Yang, N. Jia, X.L. Yang and H.B. Song
Bone metastasis is a common complication in prostate cancer patients that can cause bone pain and pathological fracture. This study tested serum levels of prostate specific antigen (PSA), alkaline phosphatase (ALP), bone sialoprotein (BSP), collagen type I pyridine crosslinking peptide (ICTP) in prostate cancer patients and th.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027707
- DOI:
- 10.4238/gmr.15027707
CYFRA21-1 levels could be a biomarker for bladder cancer: a meta-analysis
Authors: L.I. Kuang,W.J. Song,H.M. Qing,S. Yan and F.L. Song
The proteolytic region of cytokeratin-19, referred to as CYFRA21-1, is a soluble molecule present in the serum and other body fluids, and is considered a tumor marker in several neoplastic diseases. To examine whether urinary or serum samples containing CYFRA21-1 can be used as biomarkers for bladder cancer, we conducted a comprehensive meta-analysis of 3.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.6
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.6
HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk
Authors: S. Yan, Y.Z. Li, X.W. Zhu, C.L. Liu, P. Wang and Y.L. Liu
Genetic variations in the caspase genes CASP-3 and CASP-7 are known to be involved in apoptosis, cytokine maturation, cell growth and differentiation. Polymorphisms of CASP-3 and CASP-7 genes have been increasingly recognized as important regulators in the development of cancer. However, whether there is a specific association is still controversial. Ther.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.13.10
- DOI:
- 10.4238/2013.May.13.10
IL-17 rs2275913 genetic variation contributes to the development of gastric cancer in a Chinese population
Authors: B.L. Xu, Y.T. Li, S.X. Dong, J. Qi, H.M. Feng, L. Zi and D.Y. Yang
The purpose of this hospital-based case-control study was to assess whether the interleukin (IL)-17 rs2275913 genetic variation can influence susceptibility to gastric cancer. Samples from a total of 202 gastric cancer patients and 237 controls were collected from the Linyi People’s Hospital between March 2013 and March .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027756
- DOI:
- 10.4238/gmr.15027756
miR-124 radiosensitizes human esophageal cancer cell TE-1 by targeting CDK4
Authors: Y.H. Zhang, Q.Q. Wang, H. Li, T. Ye, F. Gao and Y.C. Liu
Radiotherapy is one of the most important treatments for esophageal cancer, but radioresistance remains a major challenge. Previous studies have shown that microRNAs (miRNAs or miRs) are involved in human cancers. miR-124 has been widely reported in various cancers and it is intimately involved in proliferation, cell cycle reg.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027893
- DOI:
- 10.4238/gmr.15027893
Effects of the balance between type 1 and type 2 T helper cells on ovarian cancer
Authors: C.J. Hao, J. Li, P. Liu, X.L. Li, Y.Q. Hu, J.C. Sun and Y. Wei
The balance between type 1 and type 2 T helper cells (the Th1-Th2 balance) is closely correlated with cancer, but the correlation in ovarian cancer remains unconfirmed. We investigated the Th1-Th2 balance for the diagnosis, treatment, and prognostic evaluation of ovarian cancer. Fifty healthy subjects and 50 ovarian cancer pat.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027936
- DOI:
- 10.4238/gmr.15027936
Matrix metalloproteinase 9 -1562C/T polymorphism increased protein levels in patients with colorectal cancer in a sample from southeastern Brazil
Authors: C.R. Hoelzle, K.C.S.F. Magalh�£es, S.S. Carvalho, G.A. Santos, I.M. Maia, M.C.P.S. Sousa, J.S. Andrade-Filho, G.M.G. Cruz and R.T. Sim�µes
We examined whether the allelic and/or genotypic profile of locus -1562C/T of the matrix metalloproteinase (MMP-9) gene influences the protein expression levels of MMP-9 in patients with colorectal cancer (CRC) compared with controls. A total of 104 patients with CRC and 84 controls were evaluated. Peripheral blood was collected from both groups and DNA e.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017478
- DOI:
- 10.4238/gmr.15017478
Expression levels of survivin, Bcl-2, and KAI1 proteins in cervical cancer and their correlation with metastasis
Authors: X.L. Zhou and M. Wang
Cervical cancer is associated with abnormal expression of multiple genes. Survivin and Bcl-2 proteins are apoptosis inhibitors. The tumor suppressor gene CD82, which encodes the protein KAI1, is downregulated in cervical cancer, and is associated with differentiation degree. We investigated the expression levels of three proteins and their correlation wit.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.6
- DOI:
- 10.4238/2015.December.16.6
Association between ERCC5 gene polymorphisms and gastric cancer risk in a Chinese population
Authors: R.J. Li, M. Li, G.J. Liu, Y.W. Guo, H. Bai, P. Xiao and J.Z. Mei
We conducted a hospital-based case-control study to investigate the association between 3 common SNPs in the ERCC5 gene (rs1047768, rs751402, and rs17655) and the risk of developing gastric cancer. Between January 2013 and December 2014, samples were collected from 216 gastric cancer patients and 216 control subjects. ERCC5 rs1047768, rs751402, and rs1765.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017510
- DOI:
- 10.4238/gmr.15017510