Cancer
Tumor-associated fibroblast-conditioned medium promotes tumor cell proliferation and angiogenesis
Authors: L.N. Xu, B.N. Xu, J. Cai, J.B. Yang, N. Lin
This study aimed to explore how tumor-associated fibroblasts (TAFs) promote the proliferation and angiogenesis of tumor cells via the paracrine mechanism in vitro. Conditioned media (CM) of ovarian TAFs and normal fibroblasts (NFs) were collected. Ovarian cancer cells (OCCs) were treated with 2 mL TAFs-CM and NFs-CM in experim.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.22.14
- DOI:
- 10.4238/2013.November.22.14
Azithromycin enhances the favorable results of paclitaxel and cisplatin in patients with advanced non-small cell lung cancer
Authors: D.J. Chu, D.E. Yao, Y.F. Zhuang, Y. Hong, X.C. Zhu, Z.R. Fang, J. Yu and Z.Y. Yu
Although new chemotherapeutic drugs have been applied constantly, their efficacy for non-small cell lung cancer (NSCLC) is still not satisfactory. In recent years, epidemiological investigations have shown that lung cancer may be induced by chronic Chlamydia pneumoniae (Cpn) infection, since stable high titers of Cpn antibodie.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.14.8
- DOI:
- 10.4238/2014.April.14.8
Expression profile analysis reveals putative prostate cancer-related microRNAs
Authors: H. Song1*, Y. Liu2*, J. Pan3 and S.T. Zhao1
Annotation of prostate cancer (PC) genomes provides a foundation for discoveries that can improve the understanding and treatment of the disease. Therefore, in the present study, we used the Student t-test to identify differentially expressed PC-related mRNAs and microRNAs (miRNAs). Then, we performed interrelated mapping of miRNA target genes between abn.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.24.4
- DOI:
- 10.4238/2013.October.24.4
Expression of RUNX3 gene in pancreatic adenocarcinoma and its clinical significance
Authors: L.-N. Xue, F.H. Bai2, X.-Y. Wang1, M. Lin1, Y. Tan1,2, X.-Y. Yao1 and K.-Q. Xu
We investigated the clinical significance of RUNX3 gene expression in human pancreatic carcinoma. Five samples of pancreatic tissues and 30 samples of pancreatic cancer tissues and paracancerous tissues were collected. RUNX3 expression was detected by real-time PCR and immunohistochemistry. The relationships between clinicopat.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.23.4
- DOI:
- http://dx.doi.org/10.4238/2014.May.23.4
Effects of metallothionein-3 and metallothionein-1E gene transfection on proliferation, cell cycle, and apoptosis of esophageal cancer cells
Authors: Z.Q. Tian, Y.Z. Xu, Y.F. Zhang, G.F. Ma, M. He and G.-Y. Wang
Metallothionein (MT)-3 has cell growth inhibitory activity, and is the only currently known MT subtype with unique physiological functions. The expression levels of MT-1E, a subtype of MT-1, were positively correlated with the degree of esophageal cancer malignancy. The present study aimed to investigate the effects of MT-3 and MT-1E gene transfection on .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.17.2
- DOI:
- 10.4238/2013.October.17.2
Parallel proteomic analysis in muscle-invasive bladder transitional cell carcinoma and cancer-related stroma
Authors: H.T. Niu, X.J. Qi, Y.Q. Liu, Y.W. Cao, Q. Dong and X.S. Wang
To bring about improvements in cancer biology research and elucidate mechanism-based therapeutic targets, we studied the proteome expression profile of purified normal urothelial cells (cancer cells) and normal stromal cells (cancerous stromal cells). Based on the expression profile, biomarker discovery and the mechanisms of multi-step carcinogenesis were.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.February.28.28
- DOI:
- 10.4238/2013.February.28.28
In vitro cytotoxicity screening of wild plant extracts from Saudi Arabia on human breast adenocarcinoma cells
Authors: M.A. Ali, M. Abul Farah, F.M. Al-Hemaid and F.M. Abou-Tarboush
This study investigated the in vitro anticancer activities of a total of 14 wild angiosperms collected in Saudi Arabia. The cytotoxic activity of each extract was assessed against human breast adenocarcinoma (MCF-7) cell lines by using the MTT assay. Among the plants screened, the potential cytotoxic activity exhibited by the .. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.23.9
- DOI:
- http://dx.doi.org/10.4238/2014.May.23.9
Overexpression, purification, and pharmacologic evaluation of anticancer activity of ribosomal protein L24 from the giant panda (Ailuropoda melanoleuca)
Authors: Y.L. Hou, X. Ding, W. Hou, B. Song, T. Wang, F. Wang, J. Li, J. Zhong, T. Xu, B.X. Ma, H.Q. Zhu, J.H. Li and J.C. Zhong
The ribosomal protein L24 (RPL24) belongs to the L24E family of ribosomal proteins and is located in the cytoplasm. The purpose of this study was to investigate the structure and anti-cancer function of RPL24 of the giant panda (Ailuropoda melanoleuca). The complementary DNA of RPL24 was cloned successfully using reverse transcription-polymerase chain rea.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.18.11
- DOI:
- 10.4238/2013.October.18.11
Effect of inhibition of MEK pathway on 5-aza-deoxycytidine-suppressed pancreatic cancer cell proliferation
Authors: X. Wang1, H. Wang1, N. Jiang1, W. Lu1, X.F. Zhang1 and J.Y. Fang2
Pancreatic adenocarcinoma is a lethal disease because it is inoperable at the time of diagnosis. Therefore, the search for new therapeutic approaches is critical. The abnormal expression of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK) pathway and alteration in epigenetic modification (DNA methylation and acetylation of .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.18.6
- DOI:
- 10.4238/2013.November.18.6
Associations between clinical characteristics and oncogene expression in patients with non-small cell lung cancer
Authors: Y. Han, D.P. Yu, S.J. Zhou, X.Y. Song, Y.S. Li, N. Xiao, Z.D. Liu, X.J. Sun, Q.Y. Zhao and S.K. Liu.
More than 40 oncogenes associated with non-small cell lung cancer (NSCLC) have been identified with varied gene expression. The correlations between specific clinical characteristics and oncogene expression in NSCLC patients were examined. From October 2011 to September 2012, a total of 60 patients with NSCLC (male:female, 34:24; mean age, 59.5 ± 1.. Read More»
- Genet. Mol. Res. 13(4):