Cancer
Role of the CKIP1 gene in proliferation and apoptosis of the human lung cancer cell line H1299
Authors: G.M. Chen,R.F. Ding,Y.D. Tan,X.B. Pan,G.M. Jiang,J.F. He,S.H. Lin,C. Liu and Y. Jia
Casein kinase 2 interacting protein 1 (CKIP1) is a specific interacting protein of the casein kinase 2 (CK2) α subunit, and, by binding CK2 and other proteins, functions as an adaptor to regulate a series of cellular functions. Previous studies suggested that CKIP1 might play an important role in regulating oncogenic activities. However, few studies.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.15
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.15
Association of the C677T polymorphism in the methylenetetrahydrofolate reductase gene with breast cancer in a Mexican population
Authors: A. Ramos-Silva,L.E. Figuera,O.M. Soto-Quintana,A.M. Puebla-PÃ?©rez,R. RamÃ?Ârez-PatiÃ?±o,I. GutiÃ?©rrez-Hurtado,D.I. Carrillo-Moreno, G.M. ZÃ?ºÃ?±iga-GonzÃ?¡lez,I.P. DÃ?¡valos-RodrÃ?Âguez and M.P. Gallegos-Arreola
The methylenetetrahydrofolate reductase (MTHFR) gene plays an important role in the steps involved in the processing of amino acids. The analysis of polymorphisms in the MTHFR gene has revealed associations with cancer; in particular the C677T polymorphism, which has been suggested to affect folate metabolism, DNA methylation, synthesis, and repair, and t.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.16
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.16
Effect of siRNA targeting HER2/neu on the proliferation and viability of prostate cancer PC-3M cells
Authors: C.Y. Liu, P.C. Xu, D.G. Chen, X.H. Fan, M.Q. Li, X. Yang and Y.P. Xu
The aim of this study was to investigate the effect of a small interfering RNA (siRNA) targeting human epidermal growth factor receptor 2 (HER2/neu) on the proliferation and viability of prostate cancer PC-3M cells. Chemically synthesized siRNA targeting HER2/neu was transfected into PC-3M cells by using liposomes, and cells transfected with empty liposom.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.14
- DOI:
- 10.4238/2015.December.16.14
Investigation on the role of XPG gene polymorphisms in breast cancer risk in a Chinese population
Authors: S.H. Ma, F.H. Ling, Y.X. Sun, S.F. Chen and Z. Li
We conducted a case-control study to investigate the role of XPG gene polymorphisms (rs2094258, rs751402, and rs17655) in the development of breast cancer. Patients with breast cancer (320) and control subjects (294) were consecutively selected from the Zhongshan Hospital between April 2013 and January 2015. The genotyping of .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028066
- DOI:
- 10.4238/gmr.15028066
Association of XRCC1 gene polymorphisms and pancreatic cancer risk in a Chinese population
Authors: L.J. Wang, H.T. Wang and X.X. Wang
We conducted a case-control study to assess the role of the XRCC1 Arg399Gln, Arg280His, and Arg194Trp gene polymorphisms in pancreatic cancer susceptibility in a Chinese population. A total of 152 patients diagnosed with pancreatic cancer and 264 control subjects were enrolled in this study between March 2012 and October 2014... Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028080
- DOI:
- 10.4238/gmr.15028080
Risk of colorectal cancer associated with the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the Kashmiri population
Authors: A.S. Sameer, Z.A. Shah, S. Nissar, S. Mudassar and M.A. Siddiqi
Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. The two common functional polymorphisms of MTHFR, 677 C→T and 1298 A→C, have been shown to impact various diseases, including cancer. The 677 C→T polymorphism ha.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1067
- DOI:
- 10.4238/vol10-2gmr1067
Association between N-acetyltransferase 2 polymorphisms and pancreatic cancer risk: a meta-analysis
Authors: J.X. Liang, W. Gao, Y. Liang and X.M. Zhou
N-acetyltransferase 2 (NAT2) is an essential phase II enzyme in the metabolism of aromatic and heterocyclic amines and of hydrazines. NAT2 activity can be divided into three phenotypes: rapid, intermediate, and slow. Studies identifying an association between NAT2 polymorphism and the risk of pancreatic cancer have shown conflicting results. In order to a.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.21
- DOI:
- 10.4238/2015.December.16.21
Analyzing the association between XRCC1 c.1804C>A genetic variant and lung cancer susceptibility in the Chinese population
Authors: J.J. Jin, H.Q. Wang, H.P. Kuang, B.B. Kang, Y.H. Liu and J. Wang
Lung cancer is the most common cancer occurring worldwide. The human X-ray repair complementing group 1 (XRCC1) gene is one of the most important candidate genes that influence the susceptibility to lung cancer. The objective of this study was to analyze the potential association between the c.1804C>A genetic variant of XRC.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15024661
- DOI:
- 10.4238/gmr.15024661
Association between the XPG gene Asp1104His polymorphism and lung cancer risk
Authors: B. Zhou, X.M. Hu and G.Y. Wu
It has been suggested that the xeroderma pigmentosum complementation group G (XPG) gene Asp1104His polymorphism is linked to susceptibility to lung cancer. However, the results from the published studies are contradictory rather than conclusive. With this meta-analysis, we aimed to achieve a better understanding of the effects.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027395
- DOI:
- 10.4238/gmr.15027395
IL-16 rs4778889 polymorphism contribution to the development of renal cell cancer in a Chinese population
Authors: S.X. Yang, F. Chen, J.W. Zhang, Z.Q. Sun and B.P. Chen
IL-16 plays an important role in affect the secretion of tumor-related inflammatory cytokines. We aimed to assess the role of interleukin-16 (IL-16) rs4778889 T/C and rs11556218 T/G polymorphisms in the occurrence of renal cell cancer (RCC). This study is composed of 274 RCC patients and 274 control subjects. Genotyping of pol.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027553
- DOI:
- 10.4238/gmr.15027553