Cancer
Genetic variability of DNA repair mechanisms in chemotherapy treatment outcome of gastric cancer patients
Authors: G. Zhong, H.K. Li, T. Shan and N. Zhang
We investigate whether three common polymorphisms in ERCC1 and ERCC2 are predictor factors for the chemotherapy response, as well as the clinic outcome of patients with gastric cancer. Between May 2011 and May 2013, 263 patients with gastric cancer who were newly diagnosed by histopathology were enrolled in our study. Genotyping of the ERCC1 rs11615 and r.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.22
- DOI:
- 10.4238/2015.December.16.22
Analysis of HLA-DQB1 allele polymorphisms in Uyghur women with cervical cancer
Authors: L. Han, S. Husaiyin, L. Wang, K.D. Wusainahong, X. Fu and M. Niyazi
In Uyghur women, mortality rates from cervical cancer are amongst the highest in the nation, and genetic susceptibility probably plays a role in the pathogenesis of the disease. We investigated the correlation between polymorphisms of the HLA-DQB1 allele and cervical cancer in Xinjiang Uyghur women. Cervix tissue samples from 80 cases of cervical cancer a.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.25
- DOI:
- 10.4238/2015.December.16.25
Prognostic value of miR-141 downregulation in gastric cancer
Authors: Y.B. Lu, J.J. Hu, W.J. Sun, X.H. Duan and X. Chen
Previous research has shown that microRNA-141 (miR-141) expression levels are associated with survival in several types of cancer. In the present study, we investigated the clinical significance and prognostic value of miR-141 in gastric cancer. Paired tissue specimens (tumor and adjacent normal mucosa) from 95 patients with gastric cancer were obtained a.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.31
- DOI:
- 10.4238/2015.December.16.31
Lack of association between ERCC5 gene polymorphisms and gastric cancer risk in a Chinese population
Authors: J.J. Lu, H.Q. Zhang, P. Mai, X. Ma, X. Chen, Y.X. Yang and L.P. Zhang
We conducted a case-control study to assess the association between single nucleotide polymorphisms in the ERCC5 promoter (rs2094258 and rs751402) and development of gastric cancer in a Chinese population. This investigation included 184 patients with pathologically diagnosed gastric cancer and 206 healthy subjects recruited b.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027779
- DOI:
- 10.4238/gmr.15027779
Cancer classification based on gene expression using neural networks
Authors: H.P. Hu, Z.J. Niu, Y.P. Bai and X.H. Tan
Based on gene expression, we have classified 53 colon cancer patients with UICC II into two groups: relapse and no relapse. Samples were taken from each patient, and gene information was extracted. Of the 53 samples examined, 500 genes were considered proper through analyses by S-Kohonen, BP, and SVM neural networks. Classification accuracy obtained by S-.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.33
- DOI:
- 10.4238/2015.December.21.33
Changes in T-lymphocytes in lung cancer patients after hyperthermic intraperitoneal chemotherapy or radiotherapy
Authors: L. Yan, M. Wu, N. Ba, G. Shi, L. Wang and H. Zhang
We investigated dynamic changes in T-lymphocyte subsets after hyperthermic intraperitoneal chemotherapy (HIPEC) or radiotherapy using flow cytometry. A total of 1423 lung cancer patients admitted to our hospital between October 2012 and July 2015 were enrolled, and age-matched healthy individuals served as controls. Peripheral.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027865
- DOI:
- 10.4238/gmr.15027865
HPV infection-associated anogenital cyto-colpo-histological findings and molecular typing in HIV-positive women
Authors: F.K. Tso, C.L.L. Rodrigues, J.E. Levi, M.G. Mattosinho de Castro Ferraz, N.M.G. Speck and J.C.L. Ribalta
HIV and human papillomavirus (HPV) coinfection is increasing, especially in the anal canal (AC) and cervico-vaginal regions.We identified anal epithelium abnormalities related to high-risk HPV (HR-HPV) lesions in the lower genital tracts (LGTs) of HIV-positive women, described the HPV genotypes identified, and assessed the expression of E6/E7 oncogenes in.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.36
- DOI:
- 10.4238/2015.December.21.36
Molecular analysis and conventional cytology: association between HPV and bacterial vaginosis in the cervical abnormalities of a Brazilian population
Authors: A.L. Peres, J.R.S.L. Camarotti, M. Cartaxo, N. Alencar, R.C. Stocco, W. Be�§ak, N.T. Pontes-Filho, R.F.F. Ara�ºjo, J.L. Lima-Filho and D.B.G. Martins2
We investigated the association between bacterial vaginosis (BV) and human papillomavirus (HPV) infection in Papanicolaou smears in a Brazilian population. Cross-sectional analysis was performed on 673 samples collected from women attending public health centers in Olinda (PE, Brazil) by conventionalcytology methodology and molecular analysis, PCR tests (.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.13
- DOI:
- 10.4238/2015.August.14.13
Association between XPG gene polymorphisms and development of gastric cancer risk in a Chinese population
Authors: Y.B. Feng, D.Q. Fan, J. Yu and Y.K. Bie
We conducted a case-control study to investigate the role of three common single nucleotide polymorphisms (SNPs) in the xeroderma pigmentosum complementation group G (XPG) gene (rs2094258, rs751402 and rs17655) in the development of gastric cancer in a Chinese population. Between January 2012 and December 2014, samples from a .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027877
- DOI:
- 10.4238/gmr.15027877
Mitochondrial tRNALeu(CUN) A12307G variant may not be associated pancreatic cancer
Authors: Y. Li, A.W. Huang, Y.Z. Chen, W.J. Yang, M.T. Zhou and H.W. Sun
Mitochondrial DNA mutations that lead to mitochondrial dysfunction have long been proposed to play important roles in the development of pancreatic cancer. Of these, alterations to mitochondrial tRNA genes constitute the largest group. Most recently, a variation at position 12307 in the gene encoding tRNALeu(CUN) has been repo.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027906
- DOI:
- 10.4238/gmr.15027906