Cancer
Mitochondrial ND3 G10398A mutation: a biomarker for breast cancer
Authors: Y. Yu, F. Lv, H. Lin, G. Qian, Y.S. Jiang, L.X. Pang, Y.P. Wang, X.F. Wang, Y.M. Kang, C.B. Li, Q. Liu, J.Z. Xu and W. You
Mitochondrial DNA mutations have been found to play important roles in carcinogenesis. The most common G10398A mutation, a non-conservative amino acid substitution from Thr to Ala, seems to be involved in the tumorigenesis of breast cancer. Results from studies concerning this mutation remain inconclusive. In the current study, we first took clinical and .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.12
- DOI:
- 10.4238/2015.December.21.12
Association between single nucleotide polymorphisms of X-ray repair cross-complementing protein 4 gene and development of pancreatic cancer
Authors: Y. Ding and L.N. Li
We performed a study to evaluate X-ray repair cross-complementing protein 4 (XRCC4) gene polymorphisms and the development of pancreatic cancer. A case-control study including 206 patients with newly diagnosed primary pancreatic cancer and 412 controls was performed between January 2011 and October 2013 in a Chinese population. Genotypes of XRCC4 rs180537.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.25
- DOI:
- 10.4238/2015.August.14.25
Human kallikrein 5 as a novel prognostic biomarker for triple-negative breast cancer: tissue expression analysis and relationship with disease course
Authors: F. Yang, J.Y. Li, Q.N. Yin, K. Yang, S.N. Dong, L.J. Bai, P. Liu and X.W. Tong
The purposes of this study were to analyze the expression and distribution of human kallikrein 5 (hK5) in triple-negative breast cancer (TNBC) tissues, to establish a standard operating procedure (SOP) for its immunohistochemical assay, and to evaluate the possibility of hK5 being a prognostic biomarker for TNBC. Recombinant hK5 protein and specific antib.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.28
- DOI:
- 10.4238/2015.August.14.28
Glutathione S-transferase P1 rs1695 A>G polymorphism and breast cancer risk: evidence from a meta-analysis
Authors: M. Kuang, W. Xu, C.X. Cao, L.L. Shen, J. Chang, X.L. Zhang, J.F. Chen and C.J. Tang
Breast cancer (BC) is the most widespread cause of cancer-related deaths in women. Many published studies have assessed the association between the glutathione S-transferase P1 (GSTP1) rs1695 polymorphism and BC risk. However, the effect of the GSTP1 rs1695 polymorphism on BC risk has remained controversial. Therefore, this me.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027771
- DOI:
- 10.4238/gmr.15027771
Association between ERCC5 gene polymorphisms and gastric cancer risk
Authors: B.W. Guo, L. Yang, R. Zhao and S.Z. Hao
We investigate the role of ERCC5 gene polymorphisms (rs17655 and rs751402) in the development of gastric cancer in a Chinese population. A total of 142 gastric cancer patients whose diagnoses were confirmed by pathology, and 274 control subjects were recruited from Tangshan Gongren Hospital between March 2013 and March 2015. G.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027828
- DOI:
- 10.4238/gmr.15027828
Meta-analysis of correlation between the CYP1A2 -3860 G > A polymorphism and lung cancer risk
Authors: J. Ren, B.Z. He, T.S. Zhang, S.P. Lu and T. Yan
The aim of this meta-analysis was to assess the association between a polymorphism (-3860 G > A) in the cytochrome P450 1A2 (CYP1A2) gene and lung cancer susceptibility. Relevant studies were retrieved from the PubMed and EMBase databases, and additionally evaluated for conformance with the inclusion criteria. The odds rati.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028353
- DOI:
- 10.4238/gmr.15028353
Impact of early enteral and parenteral nutrition on prealbumin and high-sensitivity C-reactive protein after gastric surgery
Authors: B. Li, H.-Y. Liu, S.-H. Guo, P. Sun, F.-M. Gong and B.-Q. Jia
We investigated the impact of early enteral nutrition (EEN) and parenteral nutrition (PN) on prealbumin (PA) and highsensitivity C-reactive protein (hs-CRP) in patients after gastric cancer surgery. Sixty-eight selected patients undergoing gastric cancer surgery were randomly divided into the EEN (N = 34) and PN (N = 34) groups. Body weight (BW), serum al.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.6
- DOI:
- 10.4238/2015.June.29.6
Impact of early postoperative enteral nutrition on clinical outcomes in patients with gastric cancer
Authors: B. Li, H.Y. Liu, S.H. Guo, P. Sun, F.M. Gong and B.Q. Jia
The impact of early enteral nutrition (EEN) on clinical outcomes of gastric cancer patients was investigated. Three hundred patients undergoing gastric cancer surgery from July 2010 to May 2014 were randomly divided into experimental and control groups (n = 150/ group). Experimental group patients received enteral nutrition in water during the early posto.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.7
- DOI:
- 10.4238/2015.June.29.7
Analysis of postoperative PSA changes after ultrasound-guided permanent [125I] seed implantation for the treatment of prostate cancer
Authors: X.L. Bian, C.Z. Wang, Y. Wang, Y.N. Li, L.Z. Zhang and L. Liu
The aim of this study was to explore postoperative changes in prostate-specific antigen (PSA) levels and risk factors that influence the clinical effects of ultrasound-guided permanent [125I] seed implantation in the treatment of prostate cancer. From July 2009 to December 2012, 41 prostate cancer patients who underwent transrectal ultrasound-guided [ 125.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.8
- DOI:
- 10.4238/2015.June.29.8
Correlation of UGT1A1 and ERCC1 gene polymorphisms with the outcome of combined irinotecan plus cisplatin treatment in recurrent ovarian cancer
Authors: Q. Xu, Y.Y. Ding, L.X. Song andJ.F. Xu
The aim of this study was to define the genotypes of UGT1A1 and ERCC1 and to examine their relationship with the efficacy and toxicity of a combination therapy of irinotecan and cisplatin in patients with advanced ovarian cancer. The allelic frequencies of the UGT1A1 and ERCC1 variants in a group of 89 patients with advanced ovarian cancer were determined.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.17
- DOI:
- 10.4238/2015.June.29.17