Cancer
Prevalence of human papillomavirus (HPV) type 16 variants and rare HPV types in the central Amazon region
Authors: M.M. Castro, I.P. Farias, C.M. Borborema-Santos, G. Correia and S. Astolfi-Filho
Infection by human papillomavirus (HPV) is one of the primary causes of mortality by cancer in northern Brazil. Sexually active women from Manaus, Amazonas, without cytological alterations and women with pre-malignant and malignant cytological alterations were examined for HPV virus, identified via PCR and sequencing. The targ.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr992
- DOI:
- 10.4238/vol10-1gmr992
SNP at miR-483-5p-binding site in the 3'-untranslated region of the BSG gene is associated with susceptibility to esophageal cancer in a Chinese population
Authors: H.Y. Li, Y.C. Liu, Y.H. Bai, M. Sun, L. Wang, X.B. Zhang and B. Cai
The aim of this study was to investigate the association between a functional variant of the basigin (BSG) gene, caused by a polymorphism (rs11473) at the miR-483-5p binding site, and the risk of esophageal squamous cell carcinoma (ESCC) in the Chinese population. The rs11473 polymorphism was genotyped in 624 esophageal cancer.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027735
- DOI:
- 10.4238/gmr.15027735
Genetic variability of ERCC1 and ERCC2 influences treatment outcomes in gastric cancer
Authors: W.H. Yu, Y.X. Wang, J.Q. Guo, Y.L. Wang, J.S. Zheng and K.X. Zhu
We performed a study to investigate the role of ERCC1 (rs11615, rs2298881, and rs3212986) and ERCC2 (rs13181, rs238406, and rs1799793) polymorphisms in the prognosis of gastric cancer. A total of 346 patients with gastric cancer were recruited between May 2009 and May 2012. Single nucleotide polymorphism genotyping was performed using the Sequenom MassARR.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.25
- DOI:
- 10.4238/2015.December.21.25
Vascular endothelial growth factor +936C/T polymorphism and cancer risk in Asians: a meta-analysis
Authors: X.L. Liu, Q.F. Yang and B.H. Kong
Vascular endothelial growth factor (VEGF), the most important regulator of angiogenesis and vascular permeability, is involved in various steps of carcinogenesis. The +936C/T polymorphism of the VEGF gene has been reported to affect the VEGF protein level and to be related to the susceptibility of cancer. However, the results of published studies, as well.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.13.1
- DOI:
- 10.4238/2013.June.13.1
Ketamine used as an acesodyne in human breast cancer therapy causes an undesirable side effect, upregulating anti-apoptosis protein Bcl-2 expression
Authors: H. He, J. Chen, W.P. Xie, S. Cao, H.Y. Hu, L.Q. Yang and B. Gong
Ketamine is a dissociative anesthetic agent that has been widely used in surgery and for relieving pain in chronic cancer patients. We applied ketamine to breast cancer cell line MDA-MB-231 to detect the effect of treatment and molecular mechanisms involved. We found that ketamine can upregulate the level of anti-apoptosis protein Bcl-2, which promotes br.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.January.4.7
- DOI:
- 10.4238/2013.January.4.7
Association between ERCC1 and ERCC2 gene polymorphisms and susceptibility to pancreatic cancer
Authors: M.G. He, K. Zheng, D. Tan and Z.X. Wang
We conducted a study to investigate the association between ERCC1 (rs3212986) and ERCC2 (rs13181) gene polymorphisms and the risk of pancreatic cancer in a Chinese population. A total of 217 pancreatic cancer patients and 244 control subjects were recruited from the Nuclear Industry 215 Hospital of Shaanxi Province between February 2013 and December 2014... Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017879
- DOI:
- 10.4238/gmr.15017879
AGER genetic polymorphisms increase risks of breast and lung cancers
Authors: N.C. Yin, X.P. Lang, X.D. Wang and W. Liu
We evaluated the associations between three common polymorphisms in the AGER gene and the risks of breast (BC) and lung (LC) cancer using meta-analysis. A systematic electronic search of the literature was conducted to identify all potential correlation studies in Embase, Web of Science, Cochrane Library, CINAHL, PubMed, CISCOM, China BioMedicine (CBM), a.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.2
- DOI:
- 10.4238/2015.December.22.2
Elevated expression of CXCR4 and correlation with clinicopathological features and prognosis of non-small cell lung cancer patients: a meta-analysis
Authors: H. Wang, F. Xie, Z. Hu and L. Chen
The specific correlation between CXCR4 expression and survival in non-small cell lung cancer (NSCLC) has been investigated independently; however, these have yielded inconsistent results. Therefore, we examined the exact relationship between CXCR4 expression and NSCLC in this meta-analysis. The bibliographic databases in English and Chinese were carefully.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.14
- DOI:
- 10.4238/2015.December.22.14
miR-125a-5p expression is associated with the age of breast cancer patients
Authors: H. He, F. Xu, W. Huang, S.Y. Luo, Y.T. Lin, G.H. Zhang, Q. Du and R.H. Duan
Dysregulated miR-125 observed in multiple cancer types has suggested that it is involved in malignant proliferation and invasion. However, the clinical significance of miR-125 in human breast cancer (BC) has not yet been fully elucidated. In the present study, the expression of miR-125a-5p/3p and miR-125b in 143 pairs of BC and normal adjacent tissues (NA.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.17
- DOI:
- 10.4238/2015.December.22.17
Clinical significance of serum miR-196a in cervical intraepithelial neoplasia and cervical cancer
Authors: P. Liu, F. Xin and C.F. Ma
Previous studies have reported that miR-196a is upregulated in cervical cancer tissues and cell lines. However, whether serum miR-196a is increased in patients with cervical cancer or cervical intraepithelial neoplasia (CIN), and its potential clinical value remained unknown. In total, 105 cervical cancer patients, 86 CIN patients, and 50 healthy voluntee.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.25
- DOI:
- 10.4238/2015.December.22.25