Cancer
Effect of SNX-2112 on proliferation of esophageal cancer cells via regulation of excision repair cross-complementing 1, epidermal growth factor receptor, and p53 expression
Authors: C.Y. Li, Y.J. Ren and Y.D. Li
SNX-2112 is a potential molecular targeted therapeutic drug against esophageal cancer (EC). However, its exact mechanism of action remains to be explained. The aim of this study was to investigate the effect of SNX-2112 on excision repair cross- complementing 1 (ERCC1), epidermal growth factor receptor (EGFR), and p53, to eluc.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028318
- DOI:
- 10.4238/gmr.15028318
Effects of stathmin 1 silencing by siRNA on sensitivity of esophageal cancer cells Eca-109 to paclitaxel
Authors: H.W. Zhu, D. Jiang, Z.Y. Xie, M.H. Zhou, D.Y. Sun and Y.G. Zhao
We investigated the effects of stathmin 1 (STMN1) silencing by small interfering (siRNA) on the sensitivity of esophageal cancer cells Eca-109 to paclitaxel. STMN1 siRNA was transiently transfected into Eca-109 cells. The effects of transfection were detected by quantitative polymerase chain reaction and western blotting. The effects of STMN1 silencing by.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.18
- DOI:
- 10.4238/2015.December.28.18
Correlation of increased MALAT1 expression with pathological features and prognosis in cancer patients: a meta-analysis
Authors: X.S. Shi, J. Li, R.H. Yang, G.R. Zhao, H.P. Zhou, W.X. Zeng and M. Zhou
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been identified as a potential cancer biomarker, yet the mechanism by which it influences the development of cancer remains unknown. In this study, we aimed to correlate MALAT1 expression with pathological features and prognosis in cancer patients. Several databases were searched using co.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.30
- DOI:
- 10.4238/2015.December.28.30
Protein-protein interaction between ezrin and p65 in human breast cancer cells
Authors: R. Tang, F.X. Li, W.F. Shao, Q.S. Wen, X.R. Yu and J.B. Xiong
Our study aimed to investigate the co-localization and protein-protein interactions between ezrin and p65 in human breast cancer cells. Liquid chromatography-mass spectrometry (LCMS) was used to uncover novel protein interactions with ezrin in MDA-MB-231 cells. Endogenous co-immunoprecipitation was used to validate protein-pro.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028334
- DOI:
- 10.4238/gmr.15028334
A clinical study evaluating dendritic and cytokine-induced killer cells combined with concurrent radiochemotherapy for stage IIIB non-small cell lung cancer
Authors: X.P. Zhu, Y.H. Xu, J. Zhou and X.F. Pan
To compare the efficacy of dendritic and cytokine-induced killer cells (DC-CIK) therapy combined with concurrent radiochemotherapy on stage IIIB non-small cell lung cancer. Sixty-three patients with stage IIIB non-small cell lung cancer were randomly divided into the study and control groups. The study group, comprising 30 patients, was treated with DC-CI.. Read More»
- Genet. Mol. Res. 14(3):
Roles of microRNA-221/222 in type 2 diabetic patients with post-menopausal breast cancer
Authors: M.Y. Li, S.R. Pan and A.Y. Qiu
The aim of the research was to examine the expression level of microRNA221/222 (miR-221/222) in the serum of patients with type 2 diabetes mellitus (T2DM) who are also diagnosed with post-menopausal breast cancer. We aimed to evaluate the differences in microRNA expression in patients with T2DM alone, patients with post-menopa.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027259
- DOI:
- 10.4238/gmr.15027259
Predictive potential role of glutathione S-transferase polymorphisms in the prognosis of breast cancer
Authors: X. Wang and Z.H. Huang
The current study aimed at evaluating the association between GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymorphisms and clinical response to chemotherapy and treatment outcome of breast cancers patients. Genotyping of GSTP1 rs1695, GSTT1 deletion, and GSTM1 deletion was performed by Polymerase Chain Reaction Restriction Fragment Length.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.7
- DOI:
- 10.4238/2015.August.28.7
Correlation between methylation of the E-Cadherin gene and malignancy of prostate cancer
Authors: S.Q. Zhang, G.Q. Zhang and L. Zhang
Prostate cancer is a common malignant tumor in males with an unclear pathogenic mechanism. As one epigenetic regulation mechanism, DNA methylation of the whole genome and specific gene(s) plays critical roles in pathogenesis, progression, diagnosis, and treatment of prostate cancer. The E-Cadherin gene is involved in cell meta.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028046
- DOI:
- 10.4238/gmr.15028046
Androgen receptor (CAG)n polymorphisms and breast cancer risk in a Han Chinese population
Authors: J. Dang, L. Peng, H.J. Zhong and Z.H. Huo
The androgen receptor (AR) is involved in the differentiation and growth of breast cancer. Genetic markers in the AR gene have a plausible role in modulating the risk of breast cancer. In this study, we studied the association of breast cancer and the trinucleotide repeat polymorphism (CAG)n in exon 1 of the AR gene in 202 patients with breast cancer and .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.10
- DOI:
- 10.4238/2015.August.28.10
Molecular-level effects of eribulin and paclitaxel on breast cancer based on differential co-expression network analysis
Authors: J. Qin and Y.H. Chen
We investigated the effects of eribulin and paclitaxel on breast cancer (BC) by exploring molecular biomarkers and pathways. Co-expression networks were constructed by differentially co-expressed genes and links, and centralities were analyzed to explore the hub genes. Pathway-enrichment analysis was performed. The hub genes w.. Read More»
- Genet. Mol. Res. 15(2):