Cancer
Association of GSTP1 and XRCC1 gene polymorphisms with clinical outcomes of patients with advanced non-small cell lung cancer
Authors: J.Y. Liu, Q.M. Liu and L.R. Li
We investigated the association between the polymorphisms GSTP1 rs1695 and XRCC1 rs1799782 and rs25487 and the clinical outcome of patients with non-small cell lung cancer (NSCLC) receiving cisplatin-based chemotherapy. Genotyping of GSTP1 rs1695 and XRCC1 rs1799782, and rs25487 was conducted by polymerase chain reaction-restriction fragment length polymo.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.19
- DOI:
- 10.4238/2015.August.28.19
Association between TNF-�± -308G>A and -238G>A gene polymorphisms and TNF-�± serum levels in Mexican colorectal cancer patients
Authors: I.A. Guti�©rrez-Hurtado, A.M. Puebla-P�©rez, J.I. Delgado-Saucedo, L.E. Figuera, G.M. Z�º�±iga-Gonz�¡lez, K. Gomez-Mariscal,C.A. Ronquillo-Carre�³n and M.P. Gallegos-Arreola
The objective of this study was to examine the association between TNF-α serum levels and -308G>A and -238G>A polymorphisms in the corresponding gene by comparing healthy subjects to colorectal cancer (CRC) patients from a Mexican population. Serum levels of TNF-α were found to significantly differ between CR.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028199
- DOI:
- 10.4238/gmr.15028199
A comprehensive review of microRNA-related polymorphisms in gastric cancer
Authors: B.W. Han Z.H. Li, S.F. Liu, H.B. Han, S.J. Dong, H.J. Zou,R.F. Sun and J. Jia
MicroRNAs (miRNAs) are a class of small non-coding RNA molecules of about 22 nucleotides in length. miRNAs are highly conserved in both plants and animals, and function as gene regulators by binding to the 3'-untranslated region of target mRNAs for cleavage and/or translational repression. miRNA biogenesis, stability, and regu.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028289
- DOI:
- 10.4238/gmr.15028289
Correlation of CYP1A1 and GSTM1 gene polymorphisms and environmental factors to familial aggregation of esophageal cancer among the Kazakh ethnic group in Xinjiang
Authors: M. Zeng, Y. Lv, H.F. Wang, H.A. Yiguli, J.R. Zhang and A. Yisikandaer
This study aimed to investigate the correlation of CYP1A1 and GSTM1 gene polymorphisms and environmental factors to familial aggregation of esophageal cancer (EC) among the Kazakh ethnic group in Xinjiang. CYP1A1 and GSTM1 gene polymorphisms were detected using peripheral blood from 86 subjects belonging to families with EC and 82 control subjects. Additi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.19
- DOI:
- 10.4238/2015.December.29.19
Analysis of CYP1A1 and COMT polymorphisms in women with cervical cancer
Authors: J.P. Kleine, C.M. Camargo-Kosugi, C.V. Carvalho, F.C. Silva and I.D.C.G. Silva
The aim of this case-control study was to obtain a comprehensive panel of genetic polymorphisms present only in genes (cytochrome P-450 1A1 - CYP1A1 and catechol-O-methyl transferase - COMT) within the metabolic pathway of sex steroids and determine their possible associations with the presence or absence of cervical cancer. Genotypes of 222 women were an.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.3
- DOI:
- 10.4238/2015.December.29.3
Deciphering the spectrum of somatic mutations in the entire mitochondrial DNA genome
Authors: X.Z. Chen, Y. Fang, Y.H. Shi, J.H. Cui, L.Y. Li, Y.C. Xu and B. Ling
The mitochondrion is a crucial intracellular organelle responsible for regulating cellular energy metabolism, producing free radicals, initiating and executing the apoptotic pathways. Previous studies have shown that somatic mutations in mitochondrial DNA are associated with various tumors, which may be involved during carcinogenesis and tumor progression.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.30.5
- DOI:
- http://dx.doi.org/10.4238/2015.April.30.5
Association between the 8q24 rs6983267 T/G polymorphism and prostate cancer risk: a meta-analysis
Authors: H.S. Zhu, J.F. Zhang, J.D. Zhou, M.J. Zhang and H.X. Hu
Recent studies have indicated that single nucleotide polymorphisms (SNPs) within the 8q24 region may be a risk factor for prostate cancer (PCa). Here, we performed a meta-analysis to evaluate the association between the 8q24 rs6983267 T/G polymorphism and PCa risk. A systematic literature search was carried out in multiple electronic databases independent.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.43
- DOI:
- 10.4238/2015.December.29.43
Direct preparation protocol to obtain mitotic chromosomes from canine mammary tumors
Authors: C.S.D. Morais, P.R.A.M. Affonso, J.A. Bitencourt and A.A. Wenceslau
Currently, mammary neoplasms in female canines are a serious problem in veterinary clinics. In addition, the canine species is an excellent disease model for human oncology because of the biological and genetic similarities between the species. Cytogenetics has allowed further study of the characterization of neoplasms in canines. We hypothesized that the.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.49
- DOI:
- 10.4238/2015.December.29.49
Downregulation of serum DKK-1 predicts poor prognosis in patients with papillary thyroid cancer
Authors: Y.P. Zhao, W. Wang, X.H. Wang, Y. Xu, Y. Wang, Z.F. Dong and J.J. Zhang
The Wnt inhibitor dickkopf-1 (DKK-1) has been shown to be closely correlated with tumor initiation and progression in various types of cancers. However, the serum level of DKK-1 in patients with papillary thyroid cancer (PTC) and its potential clinical significance is poorly understood. Enzyme-linked immunosorbent assay (ELISA) was used to evaluate the le.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.38
- DOI:
- 10.4238/2015.December.28.38
Association between MTHFR gene polymorphisms (C677T, A1298C) and genetic susceptibility to prostate cancer: a meta-analysis
Authors: P.L. Chen, W.T. Li, J. Wang, Y.D. Jiang, P. Wu, T. Chen and S.B. Zheng
Genetic polymorphisms (C677T and A1298C) in methylenetetrahydrofolate reductase (MTHFR) were shown to be related to prostate cancer risk in previous studies; however, the results are controversial. We performed a meta-analysis of previous studies and quantitatively estimated these associations. Pubmed, Embase, and Cochrane Library Database were searched f.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.29
- DOI:
- 10.4238/2015.December.29.29