Cancer
A novel human G protein-coupled receptor is over-expressed in prostate cancer
Authors: Raphael B. Parmigiani, Geraldo S. Magalh?£es, Pedro A.F. Galante,Carina V.B. Manzini, Anamaria A. Camargo and Bettina Malnic
G protein-coupled receptors (GPCRs) are involved in a large variety of physiological functions. The number of known members that belong to this large family of receptors has been rapidly increasing. Now, with the availability of the human genome sequence databases, further family members are being identified. We describe the i.. Read More»
- Genet. Mol. Res. 3(4):
Less ??mtDNA4977 than normal in various types of tumors suggests that cancer cells are essentially free of this mutation
Authors: Maria Angela C. Dani, Sergio U. Dani, Silmara P.G. Lima, Alfredo Martinez, Benedito M. Rossi, Fernando Soares, Marco A. Zago and Andrew J.G. Simpson
Levels of mtDNA4977 deletions (DmtDNA4977) have been found to be lower in tumors than in adjacent non-tumoral tissues. In 87 cancer patients, DmtDNA4977 was detected by multiplex polymerase chain reaction (PCR) amplification in 43 (49%) of the tumors and in 74 (85%) of the samples of non-tumoral tissues that were adjacent to t.. Read More»
- Genet. Mol. Res. 3(3):
The anticancer homeopathic composite â??Canova Methodâ? is not genotoxic for human lymphocytes in vitro
Authors: Igor C. Seligmann, Patr?cia D.L. Lima, Pl?nio C.S. Cardoso, Andr?© S. Khayat, Marcelo O. Bahia, Dorli de Freitas Buchi Isabel R. Cabral, Rommel R. Burbano
The Canova Methodâ (CM) is a homeopathic medicine indicated for the treatment of patients with cancer and for pathologies that involve a depressed immune system, such as AIDS. This product is composed of homeopathic dilutions of Aconitum napellus, Arsenicum album (arsenic trioxide), Bryonia alba, Lachesis muta venom and .. Read More»
- Genet. Mol. Res. 2(2):
Micronucleus investigation of alcoholic patients with oral carcinomas
Authors: Andr?©a Ramirez, Pedro Henrique Saldanha
The micronucleus test (MN) is used as an indicator of genotoxic exposition, since it is associated with chromosome aberrations. An increased mutation rate in oral squamous cells, indicated by an increased MN frequency, is also related to the development of oral carcinomas. We evaluated the frequencies of MN and other metanucle.. Read More»
- Genet. Mol. Res. 1(3):
A model system for testing gene vectors using murine tumor cells on the chorioallantoic membrane of the chick embryo
Authors: Sergio U. Dani and Rachel Espindola
We developed a model system for testing gene vectors, based on the growth of murine tumors on the chorioallantoic membrane (CAM) of embryonic chickens. The ability of selected murine cells to grow on the CAM was rated according to the following criteria: i) formation of tumor masses; ii) metastasis formation; iii) reproducibil.. Read More»
- Genet. Mol. Res. 1(2):
Molecular cytogenetics in metaphase and interphase cells for cancer and genetic research,diagnosis and prognosis. Application in tissue sections and cell suspensions
Authors: Maria M?¼hlmann
As the pioneer among molecular cytogenetics techniques, fluorescence in situ hybridization (FISH) allows identification of specific sequences in a structurally preserved cell, in metaphase or interphase. This technique, based on the complementary double-stranded nature of DNA, hybridizes labeled specific DNA (probe). The probe.. Read More»
- Genet. Mol. Res. 1(2):