Cancer
Colorectal cancer susceptibility variants alter risk of breast cancer in a Chinese Han population
Authors: W. Wei, M. Jiang, L. Luo, Z. Li, P. Wang and W.Q. Dong
Recent genome wide association studies (GWAS) and candidate gene studies have revealed many novel loci associated with colorectal cancer susceptibility. We evaluated the effect of these colorectal cancer-associated variants on the risk of breast cancer in a Chinese Han population. Seven single nucleotide polymorphisms (SNPs) (rs3856806 in PPARG, rs7014346.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.4.14
- DOI:
- 10.4238/2013.December.4.14
Lack of association between Cyclin D1 gene G870A polymorphism and esophageal cancer: evidence from a meta-analysis
Authors: W. Cai, Z.T. Wang, J. Zhong and Y. Zhang
The association between the Cyclin D1 gene (CCND1) G870A polymorphism and esophageal cancer has been widely evaluated, with conflicting results. As meta-analysis is a reliable approach to resolving discrepancies, we aimed to evaluate this association. Data were available from 9 study populations incorporating 1898 cases and 3046 controls. Overall, the all.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.April.26.1
- DOI:
- 10.4238/2013.April.26.1
Association between dietary intake of folate and MTHFR and MTR genotype with risk of breast cancer
Authors: J.M. He, Y.D. Pu, Y.J. Wu, R. Qin, Q.J. Zhang, Y.S. Sun, W.W. Zheng and L.P. Chen
We investigated the association between dietary intake of folate, vitamin B6, and the 5,10-methylenetetrahydrofolate reductase (MTHFR) genotype with breast cancer. A matched case-control study was conducted, and 413 patients with newly diagnosed and histologically confirmed breast cancer and 436 controls were recruited. Folate intake, vitamin B6, and vita.. Read More»
- Genet. Mol. Res. 13(4):
Interleukin-10 gene -592C>A polymorphism and susceptibility to gastric cancer
Authors: M. Qi, D.M. Liu, L.L. Pan and Y.X. Lin
Numerous studies have evaluated the association between the human interleukin-10 gene -592C>A polymorphism and gastric cancer risk. However, the results have been inconsistent. This meta-analysis was designed to resolve these controversies. Systematic searches of the electronic databases Embase, PubMed, and Google Scholar were performed to identify rel.. Read More»
- Genet. Mol. Res. 13(4):
Meta-analysis demonstrates lack of an association of microsomal epoxide hydrolase 1 polymorphisms with esophageal cancer risk
Authors: J.J. Hu1*, Z.T. Wang 2* and B. Li1
Epoxide hydrolases metabolize exogenous chemicals, including carcinogens such as polycyclic aromatic hydrocarbons. The relationship between microsomal epoxide hydrolase 1 (EPHX1) polymorphisms and esophageal cancer risk has been investigated in various ethnic populations, but the results have been contradictory. We investigated the association of EPHX1 Ty.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.15.2
- DOI:
- 10.4238/2013.October.15.2
Association of the tumor necrosis factor-alpha -308G>A polymorphism with breast cancer in Mexican women
Authors: L. GÃ?³mez Flores-Ramos1,2, A. Escoto-De Dios1, A.M. Puebla-PÃ?©rez3, L.E. Figuera-Villanueva4, A. Ramos-Silva1,5, R. RamÃ?Ârez-PatiÃ?±o1,2, J.I. Delgado-Saucedo3, E. Salas-GonzÃ?¡lez6, G.M. ZÃ?ºÃ?±iga-GonzÃ?¡lez7, A. Alonzo-Rojo1,2, I. GutiÃ?©rrez-Hurtado1,2 and M.P. Gallegos-Arreola1
The tumor necrosis factor-alpha (TNF-α) gene plays an important role in cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, insulin resistance, and endothelial function. Polymorphisms of TNF-α have been associated with cancer. We examined the role of the -308G>A polymorphism in this gene by comparing the genotypes.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.18.17
- DOI:
- 10.4238/2013.November.18.17
Aberrant DNA methylation of MGMT and hMLH1 genes in prediction of gastric cancer
Authors: J. Jin, L. Xie, C.H. Xie and Y.F. Zhou
We aimed to explore the association between aberrant DNA methylation of the O(6)-methylguanine-DNA methyltransferase (MGMT) and human mutL homolog 1 (hMLH1) genes with gastric cancer. A total of 283 gastric cancer patients who were confirmed by pathological diagnosis were included in our study. Aberrant DNA methylation of MGMT.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.30.9
- DOI:
- http://dx.doi.org/10.4238/2014.May.30.9
HMGB3 characterization in gastric cancer
Authors: Y. Gong, Y. Cao, L. Song, J. Zhou, C. Wang, B. Wu
Gastric cancer is a major health problem worldwide; it is the second most common cause of cancer death in the world. Recent studies indicate that the high-mobility group (HMG) of chromosomal proteins is associated with cancer progression. However, HMGB3 has been little studied. We analyzed the co-expression network between HMG.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.2.1
- DOI:
- 10.4238/2013.December.2.1
Further evidence for the contribution of the BRCA1-interacting protein-terminal helicase 1 (BRIP1) gene in breast cancer susceptibility
Authors: L.P. Ren, Y.S. Xian, D.M. Diao, Y. Chen, Q. Guo and C.X. Dang
BRCA1-interacting protein C-terminal helicase 1 (BRIP1) is a DNA helicase that influences the DNA repair ability and tumor suppressor function of BRCA1. Truncating BRIP1 mutations have been described as cancer susceptibility alleles. To evaluate BRIP1 polymorphisms as risk factors for breast cancer, we performed a detailed analysis of possible single nucl.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.22.6
- DOI:
- 10.4238/2013.November.22.6
Contribution of catechol-O-methyltransferase Val158Met polymorphism to endometrial cancer risk in postmenopausal women: a meta-analysis
Authors: G. Lin, J. Zhao, J. Wu, R. Andreevich O, W.-H. Zhang, Y. Zhang and L. Yu
Catechol-O-methyltransferase (COMT) is a critical enzyme to detoxify the carcinogenic catechol estrogen and the Val158Met polymorphism of COMT could influence its enzymatic activity. Recent epidemiological studies have investigated the correlation of COMT Val158Met polymorphism with endometrial cancer risk; however, the results are inconsistent. To better.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.10.5
- DOI:
- 10.4238/2013.December.10.5