Cancer
Comparison of the prevalence and distribution of human papillomavirus infection and cervical lesions between urban and native habitants of an Amazonian region of Peru
Authors: M. Martorell, J.A. Garcia-Garcia, D. Gomez-Cabrero, A. del Aguila
We made a study of the prevalence of human papillomavirus (HPV) and cervix lesions in an Amazonian Bora native population (Bn) and compared it with the prevalence in an urban population in Iquitos (Iq). We also examined the distribution of HPV types among abnormal cervical smears in the Iq population. Swabs and cytologies were collected from 472 females. .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.6.14
- DOI:
- 10.4238/2012.August.6.14
Association of MMP7-181A/G and MMP13-77A/G polymorphisms with colorectal cancer in a Mexican population
Authors: J.M. Moreno-Ortiz, M. GutiÃ?©rrez-Angulo, M. Partida-PÃ?©rez, J. Peregrina-Sandoval, R. RamÃ?Ârez-RamÃ?Ârez, R. MuÃ?±iz- endoza, S. SuÃ?¡rez-Villanueva, M. Centeno-Flores, V. Maciel-GutiÃ?©rrez, J.E. Cabrales-Vazquez and M.L. Ayala-Madrigal
Colorectal cancer (CRC) is characterized by enhanced expression and activity of several metalloproteinases (MMPs), including MMP13 and MMP7, which play an important role in tumor invasion and metastasis. The objective of this study was to analyze the association of functional MMP7-181A/G and MMP13-77A/G promoter polymorphisms .. Read More»
- Genet. Mol. Res. 13(2):
- 2014.February.14.1
- DOI:
- 10.4238/2014.February.14.1
KDR gene silencing inhibits proliferation of A549cells and enhancestheir sensitivity to docetaxel
Authors: R. Wei and J.-P. Zang
We investigated the effects of kinase-domain insert containing receptor (KDR) gene silencing on the proliferation of A549 cells and their sensitivity to docetaxel. After designing and synthesizing the KDR siRNA sequence, the sequence was transfected into A549 cells using Lipofectamine 2000. The expression of KDR.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.43
- DOI:
- 10.4238/2015.November.18.43
Meta-analysis of the relationship between XRCC3 T241M polymorphism and colorectal cancer susceptibility
Authors: L.Z. Zhang, Y.S. Li and H.Z. Liu
Numerous studies have evaluated the relationship between the T241M polymorphism of the X-ray repair cross-complementing group 3 (XRCC3) gene and colorectal cancer (CRC) risk. However, the specific relationship remains controversial. We conducted meta-analysis to investigate the relationship between the XRCC3 .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.48
- DOI:
- 10.4238/2015.November.18.48
Study of PIK3CA, BRAF, and KRAS mutations in breast carcinomas among Chinese women in Qinghai
Authors: Y.L. Wang, X. Dai, Y.D. Li, R.X. Cheng, B. Deng, X.X. Geng and H.J. Zhang
Phosphatidylinositol-3-OH kinase and RAS-activated signaling pathways play an important role in tumor formation. Abnormalities in relevant genes play essential roles in the occurrence and development of many human cancers. Studies of breast cancer have mainly focused on the women in western countries, but few studies have exam.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.49
- DOI:
- 10.4238/2015.November.18.49
Meta-analysis demonstrates that the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene 609 C>T polymorphism is associated with increased gastric cancer risk in Asians
Authors: Y. Zhang, Z.T. Wang and J. Zhong
The association between the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene C609T polymorphism and gastric cancer has been widely evaluated, yet with conflicting results. Data were available from seven study populations involving 2600 subjects. Overall, comparison of alleles 609T and 609C indicated a significantly increased risk (46%) for gastric cancer (95.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.13.6
- DOI:
- 10.4238/2012.August.13.6
Screening for genes that are differentially-expressed between gastric cancer cells and gastric tumor sphere cells using the gene chip technique
Authors: W.H. Shi, Y.B. Yu, Z.-Y. Li, X.-C. Guo, Z.-L. Wei and Z.-H. Zheng
The purpose of this study was to screen for genes that were differentially expressed between a human gastric carcinoma cell line (HGC-27) and their tumor spheres, using the gene chip technique. The HGC-27 cells and tumor sphere cells were cultured in vitro in a sterile environment. Total RNA was extracted from both sa.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.54
- DOI:
- 10.4238/2015.November.18.54
MLH1 and XRCC1 polymorphisms in Mexican patients with colorectal cancer
Authors: R. MuÃ?±iz-Mendoza, M.L. Ayala-Madrigal, M. Partida-PÃ?©rez, J. Peregrina-Sandoval, E. Leal-Ugarte, N. MacÃ?Âas-GÃ?³mez, V. Peralta-Leal, J.P. Meza-Espinoza, J.M. Moreno-Ortiz, R. RamÃ?Ârez-RamÃ?Ârez, S. SuÃ?¡rez-Villanueva and M. GutiÃ?©rrez-Angulo
DNA repair proteins maintain DNA integrity; polymorphisms in genes coding for these proteins can increase susceptibility to colorectal cancer (CRC) development. We analyzed a possible association of MLH1 -93G>A and 655A>G and XRCC1 Arg194Trp and Arg399Gln polymorphisms with CRC in Mexican patients. Genomic DNA samples were obtained from peripheral b.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.June.27.6
- DOI:
- 10.4238/2012.June.27.6
Expression profile of the GA733 gene family in colorectal cancer: correlation with clinicopathological parameters
Authors: I. Mamaloudis, D. Zacharoulis, M. Samara, G. Papadopoulos, S. Samara, G. Koukoulis, C. Chatzitheofilou and P. Kollia
GA733-1/-2/-3 genes have been detected in various types of cancer, although their role has not been fully clarified. GA733-2 and GA733-1 have been correlated with lymph node metastases in laryngeal cancer and liver metastases, respectively. Only a few studies have elucidated the mechanisms regulating GA73.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.42
- DOI:
- 10.4238/2015.November.18.42
Effect of ABCE1-silencing gene, transfected by electrotransfer, on the proliferation, invasion, and migration of human thyroid carcinoma SW579 cells
Authors: X. Qu and L. Zhang
We investigated the effect of an ABCE1-silencing gene on the proliferation, invasion, and migration of human thyroid carcinoma SW579 cells. We designed and synthesized targeted ABCE1-siRNA sequences and a negative control sequence (NC-siRNA), and transfected them into human thyroid cancer SW579 cells by electrotransfer to obta.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.32
- DOI:
- 10.4238/2015.November.18.32