Cancer
HIF-2�± as a prognostic marker for breast cancer progression and patient survival
Authors: H.X. Wang, C.Qin, F.Y. Han, X.H. Wang and N. Li
Malignant cells show increased invasion potency in vitro and in vivo. This process is considered to be mediated by matrix-metalloproteases (MMPs). Hypoxia-inducible factor-2α (HIF-2α) may upregulate MMP-2 expression; however, little is known about the correlation between HIF-2α and MMP-2 expressions in breast.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.January.22.6
- DOI:
- 10.4238/2014.January.22.6
Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer
Authors: P.R.S. Rodrigues, L.L. Maia, M. Santos, G.T. Peterle, L.U. Alves, J.T. Takamori, R.P. Souza, W.M. Barbosa, A.M.C. Mercante, F.D. Nunes, M.B. Carvalho, E.H. Tajara, I.D. Louro and A.M.A. Silva-Conforti
The leptin gene product is released into the blood stream, passes through the blood-brain barrier, and finds the leptin receptor (LEPR) in the central nervous system. This hormone regulates food intake, hematopoiesis, inflammation, immunity, differentiation, and cell proliferation. The LEPR Gln223Arg polymorphism has been repo.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.24.5
- DOI:
- 10.4238/2015.November.24.5
Angiotensin II type 1 receptor gene A1166C polymorphism and breast cancer susceptibility
Authors: L. Li, F. Wang, P.W. Lv, M.Z. Zhu, J.J. He, G.C. Guo, Y.T. Gu and M.L. Han
Numerous studies have evaluated the association between the angiotensin II type-1 receptor (AGTR1) gene A1166C polymorphism and breast cancer risk. However, the specific association is controversial. The aim of the present study was to derive a more precise estimation of the relationship. A comprehensive research was conducted.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.24.9
- DOI:
- 10.4238/2015.November.24.9
Detection of CK19, LUNX, and KS1/4 mRNA expression in the peripheral blood for diagnosis of micrometastases in patients with non-small cell lung cancer and their clinical implications
Authors: L. Yan, Y. Yao, L.H. Wang, M.L. Wang and X.H. Fu
The expression of CK19, LUNX, and KS1/4 mRNA biomarkers was detected in the peripheral blood of non-small cell lung cancer (NSCLC) patients to investigate the feasibility of indicating lung cancer micrometastases. Micrometastases were identified in the peripheral blood of 32 NSCLC patients, 15 benign pulmonar.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.24.17
- DOI:
- 10.4238/2015.November.24.17
Polymorphisms of DNA repair-related genes with susceptibility and prognosis of prostate cancer
Authors: X.J. Zhang, P. Liu and F. Zhu
We aimed to investigate the association between genetic variants of the DNA repair genes XPG, CSB, XPC, CCNH, and MMS19L in the nucleotide excision repair (NER) pathway and risk of prostate cancer in a population in China. This study included 229 patients with newly diagnosed and histopathologically confirmed primary prostate .. Read More»
- Genet. Mol. Res. 13(2):
- 2014.January.24.20
- DOI:
- 10.4238/2014.January.24.20
High methylation of the SEPT9 gene in Chinese colorectal cancer patients
Authors: X.L. Su, Y.F. Wang, S.J. Li, F. Zhang and H.W. Cui
Methylation of the septin 9 gene (SEPT9) occurs in higher frequency in colorectal cancer (CRC) compared to control samples, which suggests that SEPT9 methylation is a useful biomarker for screening CRC. However, the methylation status of SEPT9 in Chinese CRC patients is scarcely reported. In the present study, SEPT9 methylatio.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.January.17.5
- DOI:
- 10.4238/2014.January.17.5
Classification of colon cancer based on the expression of randomly selected genes
Authors: X.H. Tan, R. Cheng, H.P. Hu and Y.P. Bai
In order to ascertain the relationship between gene expression and colon cancer localization, a classification method based on random gene selection and a self-organizing map network is proposed. Different numbers of genes were selected randomly from 54,675 genes of 53 colon cancer patients in stage union for international can.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.19.6
- DOI:
- 10.4238/2015.October.19.6
GSTT1, GSTM1, and GSTP1 polymorphisms as a prognostic factor in women with breast cancer
Authors: A.L. Oliveira, F.F. Oliveira Rodrigues, R.E. dos Santos, R.L. Rozenowicz and M. Barbosa de Melo
The glutathione S-transferase (GST) family comprises phase-II cellular detoxification enzymes that catalyze the conjugation of chemotherapy drugs to glutathione and act on the apoptotic pathway. The aim of this study was to determine whether polymorphisms of the GSTT1, GSTM1, and GSTP1 genes are associated with different rates.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.January.22.9
- DOI:
- 10.4238/2014.January.22.9
NLRP3 rs35829419 polymorphism is associated with increased susceptibility to multiple diseases in humans
Authors: Q. Zhang, H.W. Fan, J.Z. Zhang, Y.M. Wang and H.J. Xing
Using a meta-analysis framework, we investigated the association between the NLRP3 rs35829419 polymorphism and increased susceptibility to diverse diseases in humans. Relevant published studies were identified through a comprehensive and systematic electronic search, using the following scientific literature databases: Science Citation Index, the Cochrane.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.17
- DOI:
- 10.4238/2015.October.29.17
Expression of Ras-related protein 25 predicts chemotherapy resistance and prognosis in advanced non-small cell lung cancer
Authors: Y.F. Ma*, B. Yang*, J. Li, T. Zhang, J.T. Guo, L. Chen, M. Li, J. Chu,C.Y. Liang and Y. Liu
Ras-related protein 25 (Rab25) is involved in many human malignancies. However, its role in chemotherapy response and prognosis in advanced non-small cell lung cancer (NSCLC) remains unknown. Therefore, we investigated the relationship between Rab25 and chemotherapy sensitivity and prognosis in NSCLC. Rab25 expression was assessed using immunohistochemist.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.19
- DOI:
- 10.4238/2015.October.29.19