Cancer

Quantitative assessment of the association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and digestive system cancer risk

Authors: J. Wang*, S. Yang*, F.H. Guo, X. Mao, H. Zhou, Y.Q. Dong, Z.M. Wang andF. Luo

The angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism has been reported to be associated with digestive system cancer; however, the results from previous studies have been conflicting. The present study aimed to investigate the association between the ACE I/D polymorphism and the risk of digestive system cancer using a meta-an.. Read More»

Genet. Mol. Res. 14(4):

2015.November.13.13

DOI:

10.4238/2015.November.13.13

Effect of progranulin (PGRN) on the proliferation and senescence of cervical cancer cells

Authors: X.Y. Zhang1, Z.X. Pan1, H. Liu1, J.L. Yu1, G.X. Li2, H.Y. Wang3 and M.M. Liu4

We investigated the effect of progranulin (PGRN) expression on the proliferation and senescence of cervical cancer cells. PGRN small interfering RNA (siRNA) was introduced into the SiHa and HeLa cell lines of human cervical carcinoma using liposome-mediated transfection. The expression levels of PGRN in each cell line after transfection of PGRN siRNA were.. Read More»

Genet. Mol. Res. 14(4):

2015.November.13.18

DOI:

10.4238/2015.November.13.18

Relationship between SPOP mutation and breast cancer in Chinese population

Authors: M.A. Khan, L. Zhu, M. Tania, X.L. Xiao and J.J. Fu

SPOP protein has been found to have ubiquitin ligase activity. Mutations in SPOP gene have been recently reported in some cancers such as prostate, gastric, colorectal cancer. We investigated SPOP DNA mutation in tumor tissues collected from 70 Chinese female breast cancer patients in Southwestern China by DNA sequencing. The .. Read More»

Genet. Mol. Res. 14(4):

2015.October.16.2

DOI:

10.4238/2015.October.16.2

Meloxicam increases intracellular accumulation of doxorubicin via downregulation of multidrug resistance-associated protein 1 (MRP1) in A549 cells

Authors: S.F. Chen, Z.Y. Zhang and J.L. Zhang

It has been suggested that selected COX inhibitors can overcome multidrug resistance through the inhibition of ATPâÂ?Â?binding cassette-transporter proteins thereby enhancing the inhibitory effect of doxorubicin on human tumor growth and promoting the actions of cytostatics. However, their effect on lung cancer and the molecular mechanisms involved in th.. Read More»

Genet. Mol. Res. 14(4):

2015.November.18.18

DOI:

10.4238/2015.November.18.18

Effects of gemcitabine on radiosensitization, apoptosis, and Bcl-2 and Bax protein expression in human pancreatic cancer xenografts in nude mice

Authors: Z.T. Shen, X.H. Wu, L. Wang, B. Li, X.X. Zhu

The aim of this study was to evaluate the radiosensitizing effects of gemcitabine towards human pancreatic cancer xenografts. A human pancreatic cancer xenograft model was established in nude mice, 36 of which were randomly divided into 6 treatment groups. Tumors were measured every 2 days, and the tumor volumes, growth delays.. Read More»

Genet. Mol. Res. 14(4):

2015.December.1.10

DOI:

10.4238/2015.December.1.10

SET8 expression is associated with overall survival in gastric cancer

Authors: X.L. Shi, Z.J. Guo, X.L. Wang, X.L. Liu, G.F. Shi

Genet. Mol. Res. 14(4):

2015.December.1.12

DOI:

10.4238/2015.December.1.12

Prognostic significance of head and neck squamous cell carcinoma repair gene polymorphism

Authors: E. Stur, L.P. Agostini, F.M. Garcia, G.T. Peterle, L.L. Maia,S.O. Mendes, Q.S. Anders, R.S. Reis, J.A. Santos, D.P. Ventorim, M.B. Carvalho, E.H. Tajara, M. Santos, F. Paula,A.M.A. Silva-Conforti and I.D. Louro

The aims of this study were to analyze the polymorphisms XRCC1 Arg194Trp, XRCC1 Arg399Gln, XRCC3 Thr241Met, XPC Lys939Gln, ERCC1 Asn118Asn, and RAD51 -98G>C and to verify their influence on radiotherapy response and prognosis of patients with head and neck squamous cell carcinoma (HNSCC). Peripheral blood DNA was extracted .. Read More»

Genet. Mol. Res. 14(4):

2015.October.16.11

DOI:

10.4238/2015.October.16.11

Effect of miR-146a polymorphism on biochemical recurrence risk after radical prostatectomy in southern Chinese population

Authors: M. Chen, Z.Y. Zhou, J.G. Chen, N. Tong, S.Q. Chen, Y. Yang, X.W. Zhang, H. Jiang, N. Liu, J. Liu, G.Z. Sha, W.D. Zhu, L.X. Hua, Z.J. Wang and B. Xu

Evidence has shown that miR-146a is involved in carcinogenesis and a common G/C variant (rs2910164) in the pre-miR-146a gene has been found to be associated with various cancers. We investigated the potential prognostic role of miR-146a polymorphism in prostate cancer after radical prostatectomy... Read More»

Genet. Mol. Res. 13(4):

2014.December.18.3

DOI:

10.4238/2014.December.18.3

Lack of association between the hOGG1 gene Ser326Cys polymorphism and gastric cancer risk: evidence from a case-control study anda meta-analysis

Authors: W.G. Hu, R.J. Pan, W. Cai, Z.T. Wang and Z.G. Zhu

The association between the human 8-oxoguanine glycosylase 1 (hOGG1) gene Ser326Cys polymorphism (rs1052133) and gastric cancer has been widely evaluated, yet a definitive answer to whether this association exists is lacking. We first conducted a case-control study to assess this association in a large Han Chinese population, and then performed a meta-ana.. Read More»

Genet. Mol. Res. 14(4):

2015.November.18.31

DOI:

10.4238/2015.November.18.31

Cloning and functional identification of a novel BCA3 splice

Authors: Y. Zhang, M.Y. Hu, C.X. Qiao, J.N. Feng, Z. Lin, B.F. Shen2, Y.F. Ma, Y. Li, Y.L. Li and M.

The human breast cancer-associated gene (BCA3) was first discovered in breast and prostate cancer cells lines. In vivo studies have shown that BCA3 is mainly expressed in breast tumor cells and not in normal breast and prostate tissues. To date, 3 splice variants of BCA3 have been reported: a double-absent variant lacking exon 3 and exon 5 (BCA3-1), an ex.. Read More»

Genet. Mol. Res. 13(4):

2014.December.18.7

DOI:

10.4238/2014.December.18.7