Comet Assay
Genetic damage in Mexican and South American sweet corn varieties due to the use of herbicides (Nicosulfuron and Topramezone)
Authors: M.S. Reynoso, C.M. Alvarez, L.L. De la Cruz, J.F.G. Landeros, J.J.G. S�¡nchez, A.R.A. Villalobos
In order to encourage corn production, several herbicides such as nicosulfuron and topramezone are used. Though they offer great advantages, they may affect crop productivity and may even induce DNA damage. This study evaluated genotoxic activity at two nicosulfuron concentrations (40,000 and 80, 000 ppm) and at four topramezone concentrations (1480, 148,.. Read More»
- Genet. Mol. Res. 17(4):
- http://dx.doi.org/gmr16039921
- DOI:
- http://dx.doi.org/10.4238/gmr16039921
Cytotoxic and genotoxic potential of geraniol in peripheral blood mononuclear cells and human hepatoma cell line (HepG2)
Authors: T.B. Queiroz, G.F. Santos, S.C. Ventura, C.A. Hiruma-Lima, I.O.M. Gaiv�£o and E.L. Maistro
Geraniol is an acyclic monoterpene alcohol present in the essential oil of many aromatic plants and is one of the most frequently used molecules by the flavor and fragrance industries. The literature also reports its therapeutic potential, highlighting itself especially as a likely molecule for the development of drugs against.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039777
- DOI:
- 10.4238/gmr16039777
First cytotoxic, genotoxic, and antigenotoxic assessment of Euterpe oleracea fruit oil (aÃ?§aÃ?Â) in cultured human cells
Authors: E.S. Marques, M.S.F. Tsuboy, J.C.T. Carvalho, P.C.P. Rosa, F.F. Perazzo, I.O.M. Gaiv�£o and E.L. Maistro
Euterpe oleracea Mart., popularly known as “açaí”, is a tropical fruit from the Amazon region where it has considerable economic importance. Açaí has been used as food and for several medicinal purposes. Despite the widespread use of this fruit, there is a lack of data regarding the safe.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039700
- DOI:
- 10.4238/gmr16039700
Antigenotoxic and antimutagenic effects of Schinus terebinthifolius Raddi in Allium cepa and Swiss mice: A comparative study
Authors: L.E.S. Fedel-Miyasato, A.S.N. Formagio, S.A. Auharek, C.A.L. Kassuya, S.D. Navarro, A.L. Cunha-Laura, A.C.D. Monreal, M.C. Vieira and R.J. Oliveira
It is estimated that 60% of anticancer drugs are derived directly or indirectly from medicinal plants. Schinus terebinthifolius Raddi (Anacardiaceae) is traditionally used in Brazilian medicine to treat inflammation, ulcers, and tumors. Because of the need to identify new antimutagenic agents and to determine their mechanism o.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.April.30.2
- DOI:
- http://dx.doi.org/10.4238/2014.April.30.2
Lack of genotoxicity in Astyanax bimaculatus and Oreochromis niloticus of 17�±-methyltestosterone used in fish hatcheries to produce male monosex populations
Authors: C.L.G. Rivero-Wendt1, A.L. Miranda-Vilela1, M.F.N. Ferreira1, F.S. Amorim2, V.A.G. da Silva2, H. Louvandini3 and C.K. Grisolia1
17α-Methyltestosterone (MT) is widely used in fish hatcheries of many countries to produce male monosex populations. Its genotoxic risk to fish species is not well known and studies in other in vivo models are still inconclusive. MT was tested for genotoxicity in the fish species Oreochromis niloticus (tilapia), a target species, and Astyanax bimacu.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.24.13
- DOI:
- 10.4238/2013.October.24.13
Assessing the genotoxicities of sparteine and compounds isolated from Lupinus mexicanus and L. montanus seeds by using comet assay
Authors: M.R. Silva, C.M. Alvarez, P.M. GarcÃ?Âa and M.A. Ruiz
The genus Lupinus is widely distributed. Its seeds are used for animal and human food, and Lupinus possesses pharmacological potential because of its high content of quinolizidine alkaloids and flavonoids; however, there is little available information about its genotoxicity. We used the comet assay and staminal nuclei of Tradescantia (clone 4430) to eval.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.12.12
- DOI:
- 10.4238/2014.December.12.12
Castor bean (Ricinus communis L.) as a potential environmental bioindicator
Authors: M.G. Mendes, C.D. Santos Junior, A.C.C. Dias and A.M. Bonetti
Biomonitoring of air quality using living organisms is a very interesting approach to environmental impact assessment. Organisms with a vast distribution, such as plants, are widely used for these purposes. The castor bean (Ricinus communis L.) is an oleaginous plant that can potentially be used as a bioindicator plant owing to its rapid growth and large .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.8
- DOI:
- 10.4238/2015.October.21.8
Hyperproliferative action of bovine papillomavirus: genetic and histopathological aspects
Authors: R.P. Araldi, T.C. Melo, A.C. Neves, D.D. Spadacci-Morena, R.F. Magnelli, D.G. Modolo, P.L. de-S�¡-J�ºnior, J. Mazucchelli-de-Souza, R.F. Carvalho, W. Be�§ak and R.C. Stocco
The bovine papillomavirus (BPV) causes papillomas that regress spontaneously, but can also progress to malignancy. This study evaluated the role of BPV in oncogenesis. Twenty-four samples from uninfected calves and the papillomas of BPV infected cattle were subjected to molecular diagnosis, as well as histopathological and immunohistochemical analyses. Th.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.15
- DOI:
- 10.4238/2015.October.21.15
Genotoxicity of the medicinal plant Maytenus robusta in mammalian cells in vivo
Authors: T.M. Raymundo M. Favilla R. Niero S.F. Andrade E.L. Maistro
Plants belonging to the Celastraceae family have been used in traditional medicine for their analgesic, anti-inflammatory and anti-ulcerogenic properties, among others. Maytenus ilicifolia is the principal species of this family, and is used in the treatment of gastric ulcers. However, owing to its inadequate management in Brazil, the species is becoming ext.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.24.9
- DOI:
- 10.4238/2012.August.24.9
Effects of Moquiniastrum polymorphum ssp floccosum ethnolic extract on colorectal carcinogenesis induced by 1,2-dimethylhydrazine
Authors: S.M.A. Limeiras, B.C. Oliveira, L.R. Pessatto, J.R. Pesarini, C.A.L. Kassuya, A.C.D. Monreal, W.B. Cantero, R. Antoniolli-Silva, A.C.M.B. Antoniolli-Silva, M.E.A. Stefanello, R.J. Oliveira
The objective of this study was to evaluate the effect of Moquiniastrum polymorphum ssp floccosum ethanolic extract (MPEE) on 1,2 dimethylhydrazine (DMH)-induced colorectal carcinogenesis in mice. Forty-two male Swiss mice (Mus musculus) were subdivided into six groups (N = 7/group): negative control, DMH, MPEE, pre-treatment,.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019518
- DOI:
- 10.4238/gmr16019518