Comet Assay
Genotoxic evaluation of the antimalarial drugs artemisinin and artesunate in human HepG2 cells and effects on CASP3 and SOD1 gene expressions
Authors: I. Aquino, M.S.F. Tsuboy, J.C. Marcarini, M.S. Mantovani, F.F. Perazzo and E.L. Maistro
The malaria treatment recommended by the World Health Organization involves medicines derived from artemisinin, an active compound extracted from the plant Artemisia annua, and some of its derivatives, such as artesunate. Considering the lack of data regarding the genotoxic effects of these compounds in human cells, the objective of this study was to eval.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.24.6
- DOI:
- 10.4238/2013.July.24.6
Cytogenetic toxicity and gonadal effects of 17 �±-methyltestosterone in Astyanax bimaculatus (Characidae) and Oreochromis niloticus (Cichlidae)
Authors: C.L.G. Rivero-Wendt, A.L. Miranda-Vilela, M.F.N. Ferreira, A.M. Borges and C.K. Grisolia
The synthetic hormone, 17-α-methyltestosterone (MT), is used in fish hatcheries to induce male monosex. Androgenic effects on various fish species have been reported; however, few studies have assessed possible genotoxic effects, although there are concerns about such effects in target and non-target species. We evaluated genotoxic and gonadal effec.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.4
- DOI:
- 10.4238/2013.September.23.4
Evaluation of the genotoxic activity of dicamba and atrazine herbicides in several Mexican and South American varieties of sweetcorn (Zea mays L.)
Authors: M.S. Reynoso, C.M. Alvarez, L. De la Cruz, M.D. Escoto and J.J.G. S�¡nchez
Corn is a major crop and various herbicides are used to maximize its production, which include a dicamba-atrazine mixture. This has great advantages, but can also induce DNA damage. Genotoxic activity was assessed by comet assay following application of two concentrations of dicamba-atrazine: 1000-2000 and 2000-4000 ppm. Apical meristem leaf nuclei from 1.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.5
- DOI:
- 10.4238/2015.December.11.5
Bos taurus papillomavirus activity in peripheral blood mononuclear cells: demonstrating a productive infection
Authors: T.C. Melo, R.P. Araldi, N.S.D. Pessoa, P.L. de-S�¡-J�ºnior, R.F. Carvalho, W. Be�§ak and R.C. Stocco
Bovine papillomavirus (BPV) is an oncogenic virus with mucous and epithelial tropism. Possible productive virus infection in other tissues, such as blood, has been hypothesized. In order to investigate this possibility, three samples of skin papillomas and blood were collected from bovines with BPV infection and five samples of peripheral blood and one sa.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.19
- DOI:
- 10.4238/2015.December.11.19
In vitro genotoxicity assessment of caffeic, cinnamic and ferulic acids
Authors: E.L. Maistro, J.P.F. Angeli, S.F. Andrade and M.S. Mantovani
Phenols are a large and diverse class of compounds, many of which occur naturally in a variety of food plants; they exhibit a wide range of biological effects, including antibacterial, anti-inflammatory, antiallergic, hepatoprotective, antithrombotic, antiviral, anticarcinogenic, and vasodilatory actions. We examined the genotoxic and clastogenic potentia.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1278
- DOI:
- 10.4238/vol10-2gmr1278
Detection of protein and DNA damage induced by elevated carbon dioxide and ozone in Triticum aestivum L. using biomarker and comet assay
Authors: E. Abdelhaliem and A.A. Al-Huqail
This study was designed to compare the genetic effects of elevated carbon dioxide (CO2) and ozone (O3), alone or in combination, under irrigated and non-irrigated conditions on proteins and DNA of wheat (Triticum aestivum L.). Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), isozymes, random amplified poly.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028736
- DOI:
- 10.4238/gmr.15028736
Occupational genotoxicity risk evaluation through the comet assay and the micronucleus test
Authors: M.G. Martino-Roth, J. Vi�©gas, D.M. Roth
The micronucleus (MN) test and the alkaline single cell gel or comet assay were applied to exfoliated cells of the buccal mucous in order to evaluate the genotoxic risk associated with occupational exposure of 10 storage battery renovation workers, and 10 car painters, with age matched controls, in Pelotas, RS, in southern Brazil. In the MN test, 2000 exf.. Read More»
- Genet. Mol. Res. 2(4):
Genotoxic evaluation of the organophosphorous pesticide temephos
Authors: Cl�¡udia Alessandra Fortes Aiub, Elis�¢ngela Cristina Alves Coelho, Eduardo Sodr�©, Luis Felipe Ribeiro Pinto and Israel Felzenszwalb
The chemical compound temephos (0,0,0',0'-tetrametyl-0,0'-thiodi-p-phenylene phosphorothioate) is an organophosphorous pesticide that has been used in Brazil since 1967 in control campaigns against the mosquito Aedes aegypti, the vector of dengue and yellow fever. We used single cell gel electrophoresis (SCGE), SOS/umu and Ame.. Read More»
- Genet. Mol. Res. 1(2):