Effector
Co-targeting the EGFR and PI3K/Akt pathway to overcome therapeutic resistance in head and neck squamous cell carcinoma: What about autophagy?
Authors: Hannah Zaryouh, Jinthe Van Loenhout, Marc Peeters, Jan Baptist,Vermorken, Filip Lardon, An Wouters
Recent insights in the PI3K/Akt pathway as a promising therapeutic target in combination with EGFR-targeting agents to treat head and neck squamous cell carcinoma. The Epidermal Growth Factor Receptor (EGFR) is overexpressed in the majority of Head and Neck Squamous Cell Carcinomas (HNSCC). This triggered the development of multiple anti.. Read More»
- Genet. Mol. Res. 20(6):
Construction and expression of prokaryotic expression vectors fused with genes of Magnaporthe oryzae effector proteins and mCherry
Authors: Y.Q. Yang, H. Wang, M.L. Liang, J.L. Yan, L. Liu, C.Y. Li and J. Yang
The aim of the current study was to investigate the prokaryotic expression of the Magnaporthe oryzae effector genes BAS1 and BAS4 fused to the fluorescent protein mCherry. Based on previous polymorphic analysis of BAS1 and BAS4 in rice blast strains using PCR, blast strains containing the PCR products of BAS1 and BAS4 were selected for liquid culture for .. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.21
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.21
HydroCalc Proteome: a tool to identify distinct characteristics of effector proteins
Authors: G.J. da Silva, R.G.T.M. da Silva, V.A. Silva, E. C. Carit�¡, A.L. Fachin and M. Marins
Bacterial pathogenicity is associated with secretion of effector proteins into intra- and extracellular spaces. These proteins interfere with cellular processes such as inhibition of phagosome-lysosome fusion, induction of apoptosis and autophagy, activation and suppression of kinases, regulation of receptor activity, and modulation of transcription facto.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038111
- DOI:
- 10.4238/gmr.15038111
Construction of overexpression vectors of Magnaporthe oryzae genes BAS1 and BAS4 fusion to mCherry and screening of overexpression strains
Authors: M.L. Liang, J.L. Yan, Y.Q. Yang, L. Liu, C.Y. Li and J. Yang
The aim of this study was to construct overexpression vectors and selecting strains of the Magnaporthe oryzae effectors BAS1 and BAS4. Primer pairs of BAS1, BAS4, and mCherry were designed based on their known nucleotide sequences. The coding sequences of BAS1 and BAS4 were amplified, and the pXY201 plasmid was selected as a template to amplify the mCherr.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.17
- DOI:
- 10.4238/2015.June.26.17
Sequence characterization, polymorphism, and tissue expression profile of an effector immediate-early gene: activity-regulated cytoskeletal associated protein gene (Arc/Arg3.1) in swamp and river buffalo
Authors: F. Yuan, J.L. Huo1, D.L. Li, Y.Y. Yuan, W.Z. Lu, S. Song, L.J. Li and Y.W. Miao
The activity-regulated cytoskeletal associated protein (Arc/Arg3.1) has been implicated in experience-dependent synaptic plasticity and memory formation. However, information regarding its coding gene in buffalo remains scarce. In this study, the full-length of Arc/Arg3.1 was isolated and characterized (accession No. JX491649).. Read More»
- Genet. Mol. Res. 13(1):
- 2014.March.31.10
- DOI:
- 10.4238/2014.March.31.10