Estrogen
Interleukin-7 receptor gene rs12516866 polymorphism decreases the susceptibility of estrogen receptor negative Saudi women to breast cancer
Authors: Mikhlid Almutairi, Rafa Almeer, Abdullah M Alhadeq and Abdelhabib Semlali
Background: Genetic polymorphisms in IL-7R are associated with the risk of development of multiple diseases, including breast malignancy. At present, no evidence exists for an influence of gene polymorphism of IL-7R on BC susceptibility in Saudi Arabian populations. The aim of the study was therefore to evaluate whether common polymorphisms in the IL-7R g.. Read More»
- Genet. Mol. Res. 17(4):
- http://dx.doi.org/gmr16039935
- DOI:
- http://dx.doi.org/10.4238/gmr16039935
Association of the estrogen receptor-�² gene RsaI and AluI polymorphisms with human idiopathic thin endometrium
Authors: A.W. Le, Z.H. Wang, R. Yuan, L.L. Shan, T.H. Xiao, R. Zhuo, Y. Shen
The aim of this study was to investigate the potential correlation between polymorphisms of the estrogen receptor (ER)-β gene (RsaI and AluI) and ethnic Han Chinese human idiopathic thin endometrium. A total of 120 patients with idiopathic thin endometrium and 120 sterility patients with normal endometrium thickness (cont.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.26.7
- DOI:
- 10.4238/2013.November.26.7
In vivo and in vitro inhibitory action of 17�²-estradiol and environmental estrogen 4-nonylphenol on gonad-inhibiting hormone (GIH) expression in the eyestalks of Litopenaeus vannamei
Authors: G.L. Li*, H.P. Chen*, S.P. Deng, M. Ye, S. Jiang, S.F. Chan and C.H. Zhu
The gonad-inhibiting hormone (GIH) belongs to a neuropeptide family synthesized and released in an X-organ sinus gland complex of crustacean eyestalks. GIH inhibits crustacean ovarian maturation by suppressing vitellogenin (Vtg) synthesis, whereas estrogen is responsible for the stimulation of vitellogenesis (not established). In this study, the effects o.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.25
- DOI:
- 10.4238/2015.October.29.25
ESR1 gene polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G) may not be directly correlated with cardiovascular disease risk
Authors: N. Jiang, G. Yang and C.L. Peng
The aim of this meta-analysis was to evaluate the correlations between the estrogen receptor 1 (ESR1) gene polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G) and the risk of cardiovascular disease (CVD). Case-control studies were screened and selected from a larger group of studies that were retrieved through a comprehensive search of scient.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.14
- DOI:
- 10.4238/2015.October.29.14
Evaluation of the mutagenicity and antimutagenicity of soy phytoestrogens using micronucleus and comet assays of the peripheral blood of mice
Authors: A.M. Niwa R.J. Oliveira M.S. Mantovani
Studies show that soy imparts many favorable properties in the human body, including the prevention of chronic diseases such as osteoporosis, heart disease, cancer, and diabetes. Soy is rich in isoflavones, and it is a candidate for the chemoprevention of diseases owing to its low toxicity. In this study, a soy phytoestrogen (with high levels of the isoflavo.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.February.27.1
- DOI:
- 10.4238/2013.February.27.1
Estrogenic effects of flavonoid components in Xiaoyao powder
Authors: J.H. Chen1, N. Zhang1, Y.Q. Wang1, J.Z. Wang1, S.X. Ji1, W.J. Dang1, S.M. Li2 and L. Feng2
The objective of this study was to evaluate the estrogenic effects and mechanisms of three flavonoid components in Xiaoyao powder: quercetin, kaempferol, and isorhamnetin. The drugs were used to treat estrogen receptor (ER)-positive human breast cancer MCF-7 cells, and proliferation was measured using the MTT method. The expression of proteins and mRNA of.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017500
- DOI:
- 10.4238/gmr.15017500
Correlation between polymorphisms in the estrogen receptor �± gene and coronary heart disease: A meta-analysis
Authors: W. Zhou, K.H. He and M.H. Chen
The aim of this study was to conduct a systematic evaluation the correlation between polymorphisms in the estrogen receptor α gene (ESRα) and coronary heart disease susceptibility. Case-control studies until August 2015 analyzing the correlation between the ESRα PvuII T/C polymorphism and coronary heart disease were obtained from various.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037835
- DOI:
- 10.4238/gmr.15037835
Polymorphisms in CYP17, COMT, and ESR1 genes in women after menopause and association with bone mineral density
Authors: C.G. Gon�§alves, B.C. Almeida, C.M. Camargo-Kosugi, A.M.M. Costa, I.D.C.G. Silva, M.A. Haidar
In this study, we evaluated genetic factors related to the mineral density during post-menopause. We evaluated 110 women in the first 5 years post-menopause, without previous hormone replacement therapy. Cytochrome P450 17 (CYP17) (rs743572), catechol-O-methyl transferase (COMT) (rs4680), and estrogen receptor 1 (ESR1) (rs9322.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.32
- DOI:
- 10.4238/2015.December.1.32
Validation of associations between ESR1 variants and breast cancer risk in Chinese cohorts
Authors: X. Li, G.Y. Yao, F.X. Li, Y.R. Qiu and X.X. Yang
Estrogen receptor-a (ER) protein plays a key role in breast carcinogenesis, and common genetic variants in the corresponding gene locus have been associated with breast cancer risk in different populations. Here, we analyzed estrogen receptor 1 (ESR1) associations in two hospital-based studies of patients from the south of China. Three single-nucleotide p.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15036683
- DOI:
- 10.4238/gmr.15036683
Effects of icariin on the expression of ER, VEGF, and KDR in the endometrial cells of thin endometrium
Authors: A.W. Le, L. Shan, Z.H. Wang, X.Y. Dai, T.H. Xiao and R. Zuo
We explored the effects of icariin on the expression of estrogen receptor (ER), vascular endothelial growth factor (VEGF), and kinase insert domain receptor (KDR) in the endometrial cells of the thin endometrium. Primary endometrial cells were obtained and divided into a blank control group, a high-, a middle-, and a low-dose icariin groups, as well as an.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.22.19
- DOI:
- http://dx.doi.org/10.4238/2015.September.22.19