Estrogen
Estrogen receptor alpha gene PvuII polymorphism and risk of fracture in postmenopausal women: a meta-analysis
Authors: W. Deng, J.C. Han, L. Chen and W.L. Qi
Numerous studies have evaluated the association between estrogen receptor alpha (ESR1) gene PvuII polymorphism and fracture risk in postmenopausal women. However, the results have been inconsistent. We performed a meta-analysis to examine the association between the ESR1 gene PvuII polymorphism and fracture risk in postmenopausal women. Studies published fro.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.8
- DOI:
- 10.4238/2015.February.13.8
Effects of bisphenol A on decreasing the percentage and promoting the growth of stem cell-like cells from SK-N-SH human neuroblastoma cells
Authors: J.C. Zheng, S.Q. Qi, L. Yang, Y.Y. Ma, K.R. Dong, H.T. Zhu, S.B. Yang, T. Xu, S. Zheng and X.M. Xiao
Bisphenol A (BPA) is an industrial contaminant and is reported to be a risk factor associated with the development of tumors. In our previous studies, we have shown that BPA promoted the growth of SK-N-SH human neuroblastoma cells and increased their invasion and metastasis. In this study, we further investigated the effects of BPA and 17b-estradiol (E2) .. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.8
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.8
Gly71Arg UGT1A1 polymorphism is associated with breast cancer susceptibility in Han Chinese women
Authors: J. Shi, L.H. Li, X.Y. Duan, Q. Liu, L.L. Sun and Y.T. Tian
Breast cancer is among the most common causes of cancer-related death in women worldwide. Previous studies have demonstrated an association between prolonged estrogen exposure and increased risk of breast cancer. Uridine 5'-diphospho-glucuronosyltransferase 1-1 (UGT1A1) plays a significant role in the detoxification of estrogens. Two major genetic polymor.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038332
- DOI:
- 10.4238/gmr.15038332
Molecular cloning, expression, and regulation of estrogen receptors in pigeon oviduct epithelial cells
Authors: H. Zhang, F. Chen, G.L. Li, Y.Y. Ding, Z.R. Tao, J.J. Li,S.L. Zhong and L.Z. Lu
Estrogen regulates reproductive behavior and drives the proliferation and differentiation of several cell types. These physiological functions of estrogen are mediated by estrogen receptors (ERs), and each ER isoform plays a distinct role. To clarify the molecular mechanism of estrogen action and to evaluate the effect of ERs .. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.17.20
- DOI:
- http://dx.doi.org/10.4238/2014.March.17.20
Roles of ER�± and ER�² in estrogen-induced DDP chemoresistance in non-small cell lung cancer
Authors: N. Yu, L. Dou, Y. Li, L. Deng, X. Wei and Y. Guo
The role of estrogen in inducing chemoresistance is not yet fully understood. The objective of this study was to observe the relationship between estrogen levels and cellular response to chemotherapeutic drugs in non-small cell lung cancer (NSCLC) and to reveal the potential mechanisms involved. Cell viability was analyzed after pre-treating NSCLC cells w.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038995
- DOI:
- 10.4238/gmr.15038995
Genetic polymorphisms in patients with endometriosis: an analytical study in Goi�¢nia (Central West of Brazil)
Authors: K.S.F. Silva and K.K.V.O. Moura
In healthy women, intra- and extracellular controls prevent the attachment and proliferation of ectopic endometrial cells. During endometriosis, abnormalities in these control mechanisms permit the survival of endometrial cells, their subsequent attachment to the peritoneal cavity, and disease progression. These abnormal cells.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028135
- DOI:
- 10.4238/gmr.15028135
Relationship between estrogen receptor 1 gene polymorphisms and postmenopausal osteoporosis of the spine in Chinese women
Authors: D.P. Shang, H.Y. Lian, D.P. Fu, J. Wu, S.S. Hou and J.M. Lu
The purpose of this study was to evaluate single nucleotide polymorphism (SNP) variants of the estrogen receptor 1 gene (ESR1) at rs2234693 and rs9340799, as well as to investigate the relationship between ESR gene polymorphisms and postmenopausal osteoporosis (OP) of the spine in Chinese women. We recruited 198 postmenopausal.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028106
- DOI:
- 10.4238/gmr.15028106
Influence of the XbaI polymorphism in the estrogen receptor-�± gene on human spermatogenic defects
Authors: J. Meng, X. Mu and Y.M. Wang
Polymorphisms of estrogen receptor (ER) genes have been implicated in male infertility, but studies of this association have produced conflicting results. The present study was conducted to examine whether polymorphisms within the ERα and ERβ genes are susceptibility factors for human male idiopathic infertility in Chinese men. We investigated .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.11.1
- DOI:
- 10.4238/2013.June.11.1
Estrogen receptor 1 PvuII and XbaI polymorphisms and susceptibility to Alzheimer�s disease: a meta-analysis
Authors: Y.H. Lee and G.G. Song
The aim of this study was to explore whether estrogen receptor 1 (ESR1) PvuII and XbaI polymorphisms are associated with susceptibility to Alzheimer’s disease (AD). We conducted a meta-analysis of the associations between AD and ESR1 PvuII and XbaI polymorphisms as well as haplotypes of the ESR1 PvuII and XbaI polymorphisms. A total of 1359 patients.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.17
- DOI:
- 10.4238/2015.August.10.17
RsaI polymorphism of the ER�² gene in women with endometriosis
Authors: R.C.P.C. Silva, I.R. Costa, B.M Bordin, C.T.X. Silva, S.R. Souza, C.L.R. J�ºnior, A.B. Frare and K.K.V.O. Moura
We examined the frequency of RsaI polymorphism of the ERβ gene in 54 patients diagnosed with endometriosis and 46 controls. Peripheral blood was collected from women undergoing laparoscopy with a confirmed diagnosis of endometriosis. Polymorphisms of the ERβ gene and p53 were assessed by PCR and analyzed on 2% agaros.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr940
- DOI:
- 10.4238/vol10-1gmr940