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Estrogen

Human Genetics   Research Article

Daidzein promotes osteoblast proliferation and differentiation in OCT1 cells through stimulating the activation of BMP-2/Smads pathway

Authors: B. Hu, B. Yu, D. Tang, S. Li and Y. Wu

Daidzein, the most widely studied soy phytoestrogen, is not only a potential antiosteoporosis agent owing to its possible osteogenic activity, but also shows anticancer activity. However, the mechanisms through which daidzein affects osteoblast function have not been investigated thoroughly. Here, we show that daidzein stimula.. Read More»

Genet. Mol. Res. 15(2):
gmr.15028792
DOI:
10.4238/gmr.15028792
Animal Genetics   Research Article

Cross-contamination with tamoxifen induces transgene expression in non-exposed inducible transgenic mice

Authors: Rachael L. Brake, Paul J. Simmons and C. Glenn Begley

Inducible transgenic mouse models that impose a constraint on both temporal and spatial expression of a given transgene are invaluable. These animals facilitate experiments that can address the role of a specific cell or group of cells within an animal or in a particular window of time. A common approach to achieve inducibilit.. Read More»

Genet. Mol. Res. 3(4):