Expression
Decoherence in yeast cell populations and its implications for genome-wide expression noise
Authors: M.R.S. Briones F. Bosco
Gene expression “noise” is commonly defined as the stochastic variation of gene expression levels in different cells of the same population under identical growth conditions. Here, we tested whether this “noise” is amplified with time, as a consequence of decoherence in global gene expression profiles (.. Read More»
- Genet. Mol. Res. 8(1):
- vol8-1gmr531
- DOI:
- 10.4238/vol8-1gmr531
Global gene expression profile in myelodysplastic syndromes using SAGE
Authors: C.F. Mendiburu, W.A. Silva Jr., O. Ricci Jr., C.R. Bonini-Domingos and A.C. Fett-Conte
The molecular pathogenesis of myelodysplastic syndromes (MDS) is poorly understood. In order to expand our knowledge of genetic defects in MDS, we determined the overall profile of genes expressed in bone marrow from patients with refractory anemia with excess blasts (RAEB) by serial analysis of gene expression (SAGE). The present report describes a parti.. Read More»
- Genet. Mol. Res. 7(4):
- vol7-4gmr521
- DOI:
- 10.4238/vol7-4gmr521
Transcriptional analysis of atrial and ventricular muscles from rats
Authors: Y. Zhi3*, Z. Cao2*, Q.H. Li1, X.L. Li1, Y. Sun1, T. Zhang1 and Q. Zhang1
Previous studies have used microarray technology to explore gene expression differences between the atrium and the ventricle. However, selection criteria for the differentially expressed genes (DEGs) based only on either the fold change or the P value in these studies. Here, we aim to further identify the DEGs by setting a P value threshold of 2, which ma.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017330
- DOI:
- 10.4238/gmr.15017330
Molecular characterization and tissue expression profile of porcine Ephrin-B2
Authors: D. Xu and H.M. Ma
Ephrin-B2 (EFNB2) is a signaling molecule that plays an important role in cell adhesion, proliferation, and migration in humans. However, little is known about this molecule in pigs. In order to investigate whether EFNB2 is associated with the skeletal muscle in pigs, we cloned the full-length cDNA of EFNB2 (GenBank accession No. KF500033) from the longis.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017463
- DOI:
- 10.4238/gmr.15017463
Expression profiles of phosphatidylinositol phosphate kinase genes during normal human in vitro erythropoiesis
Authors: T.R. Zaccariotto C. Lanaro D.M. Albuquerque M.N.N. Santos M.A.C. Bezerra F.G.P. Cunha I. Lorand-Metze A.S. Araujo F.F. Costa M.F. Sonati
Phosphatidylinositol phosphate kinases (PIPKs) are enzymes that participate in diverse intracellular signaling pathways. They are classified into 3 functionally distinct subfamilies - PIPKI (a, b, g), PIPKII (a, b, g), and PIPKIII - located in various subcellular compartments. Recently, the PIPKIIa and b-globin genes were found to be overexpressed in reticul.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.November.12.3
- DOI:
- 10.4238/2012.November.12.3
Regulation of bolting and identification of the �±-tubulin gene family in Brassica rapa L. ssp pekinensis
Authors: Y.W. Zhang1,2, D. Jin1, C. Xu1, L. Zhang1, M.H. Guo1 and Z.Y. Fang3
Microtubules are important components of eukaryotic cells, and they play vital roles in cell morphogenesis, carrying of signaling molecules, transport of materials, and establishing the cell polarity. During bolting of biennial plants, cell division and elongation are involved, and cell elongation inevitably involves the microtubules arrangement and expre.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017507
- DOI:
- 10.4238/gmr.15017507
Chemical synthesis and improved expression of recombinant human granulocyte colony-stimulating factor cDNA
Authors: S. Alrokayan
Recently, granulocyte colony-stimulating factor (G-CSF) has been recognized as a useful molecule for the treatment of a wide range of complex ailments, such as cancer, AIDS, H1N1 influenza, cardiac and neurological diseases. The vast therapeutic potential of G-CSF has induced scientists to develop biotechnological approaches f.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.31.18
- DOI:
- 10.4238/2011.October.31.18
Screening of key genes of unruptured intracranial aneurysms by using DNA microarray data analysis techniques
Authors: L. Chen, Y. Fan and J. Wan
This study aimed to identify differentially expressed genes (DEGs) of unruptured intracranial aneurysms (IAs) and provide beneficial information for early diagnosis and treatment of IAs. The gene expression profile GSE26969 from the Gene Expression Omnibus database was downloaded, which included six human IA samples: three int.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.31.2
- DOI:
- 10.4238/2014.January.31.2
Molecular cloning, tissue expression pattern, and copy number variation of porcine SCUBE3
Authors: X. Liu*, L.G. Wang*, L.C. Zhang, H. Yan, K.B. Zhao, J. Liang, N. Li, L. Pu,T. Zhang and L.X. Wang
The signal peptide CUB EGF-like domain-containing protein 3 (SCUBE3) gene is a member of SCUBE gene family and plays important roles in bone cell biology and the determination of limb bone length. In this study, the full-length transcript of porcine SCUBE3 was cloned using reverse transcription-polymerase chain reaction and rapid amplification of cDNA end.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017010
- DOI:
- 10.4238/gmr.15017010
Transcriptome analysis of skeletal muscle at prenatal stages in Polled Dorset versus Small-tailed Han sheep
Authors: N. Liu, J.N. He, W.M. Yu, K.D. Liu, M. Cheng, J.F. Liu, Y.H. He, J.S. Zhao and X.X. Qu
The objectives of the present study were to identify additional genes that may play important roles in the regulation of skeletal muscle growth and development, and to provide fundamental information for understanding the underlying molecular mechanisms. Eighteen cDNA libraries were constructed from the longissimus muscle of Polled Dorset (PD) and Small-t.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.6.12
- DOI:
- 10.4238/2015.February.6.12