Expression
Transcriptomic differences of genes in the avian target of rapamycin (avTOR) pathway in a divergent line of meat-type chickens selected for feed efficiency
Authors: J. Lee and S.E. Aggrey
Avian target of rapamycin (avTOR) is a highly conserved serine-threonine kinase that serves as an intracellular energy and nutrient sensor and regulates cell division, growth, and apoptosis. The role of avTOR in mediating feed intake and growth in poultry is unknown. We studied avTOR signaling activities in duodenum and liver .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027120
- DOI:
- 10.4238/gmr.15027120
Molecular-level effects of eribulin and paclitaxel on breast cancer based on differential co-expression network analysis
Authors: J. Qin and Y.H. Chen
We investigated the effects of eribulin and paclitaxel on breast cancer (BC) by exploring molecular biomarkers and pathways. Co-expression networks were constructed by differentially co-expressed genes and links, and centralities were analyzed to explore the hub genes. Pathway-enrichment analysis was performed. The hub genes w.. Read More»
- Genet. Mol. Res. 15(2):
Genetic effect of an A/G polymorphism in the HSP70 gene on thermotolerance in chicken
Authors: Z.Y. Chen, W.W. Zhang, J.K. Gan, L.N. Kong, X.Q. Zhang,D.X. Zhang and Q.B. Luo
Studying thermotolerance is important for the prevention of thermostress in chickens. This study aimed to analyze the effect of mutations in the heat shock protein 70 (HSP70) gene on chicken thermotolerance. The C.-69A>G SNP in the 5'-flanking region of the HSP70 gene was genotyped in Lingshan and White Recessive Rock (WRR).. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028271
- DOI:
- 10.4238/gmr.15028271
Constructing gene network based on biclusters of expression data
Authors: F. Liu, L. Yang, Z.Z. Tian, P. Wu and S.L. Sun
Two genes can be co-regulated and possibly have the similar function if they are similarly expressed, which provides a theoretical basis for construction of gene regulatory networks using gene expression data. Herein, a new method of gene regulatory network was constructed based on biclusters in this paper. Given a bicluster, .. Read More»
- Genet. Mol. Res. 15(2):
Molecular cloning and expression analysis of female sterile homeotic gene (fsh) in the oriental river prawn Macrobrachium nipponense
Authors: W.Y. Zhang, S.F. Jiang, Y.W. Xiong, H.T. Fu1,, H. Qiao, S.M. Sun, Y.S. Gong and S.B. Jin
The gene female sterile homeotic (fsh) plays crucial roles in molecular function, including protein kinase activity and DNA binding, which are involved in biological processes such as terminal region determination and negative regulation of DNA-dependent transcription. Although fsh has been found in Drosophila melanogaster, little is known regarding its e.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.30.4
- DOI:
- http://dx.doi.org/10.4238/2015.April.30.4
Genome-wide analysis of the GRAS gene family in physic nut (Jatropha curcas L.)
Authors: Z.Y. Wu, P.Z. Wu, Y.P. Chen, M.R. Li, G.J. Wu and H.W. Jiang
GRAS proteins play vital roles in plant growth and development. Physic nut (Jatropha curcas L.) was found to have a total of 48 GRAS family members (JcGRAS), 15 more than those found in Arabidopsis. The JcGRAS genes were divided into 12 subfamilies or 15 ancient monophyletic lineages based on the phylogenetic analysis of GRAS proteins from both flowering .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.31
- DOI:
- 10.4238/2015.December.29.31
Characterization and functional analysis of a chitin synthase gene (HcCS1) identified from the freshwater pearlmussel Hyriopsis cumingii
Authors: H.F. Zheng, Z.Y. Bai, J.Y. Lin, G.L. Wang, J.L. Li
The triangle sail mussel, Hyriopsis cumingii, is the most important freshwater pearl mussel in China. However, the mechanisms underlying its chitin-mediated shell and nacre formation remain largely unknown. Here, we characterized a chitin synthase (CS) gene (HcCS1) in H. cumingii, and analyzed its possible physiological function. The complete ORF sequence.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.36
- DOI:
- 10.4238/2015.December.29.36
MicroRNA screening and functional study of obliterative bronchiolitis in a rat model simulating lung transplantation
Authors: J. Wang, H. Cao, X. Hong, G.H. Chen, H.M. Fan, Q.C. Li, Z.M. Liu and K.F. Li
The aim of this study was to provide the experimental basis for effective prevention and treatment of obliterative bronchiolitis (OB) by studying the changes on the microRNA (miRNA) expression profile after an orthotopic tracheal transplantation (OTT) simulating lung transplantation (LT). The OTT was performed on inbred rats to establish an OB animal mode.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.40
- DOI:
- 10.4238/2015.December.29.40
Expression profiles of differentially expressed genes affecting fecundity in goat ovarian tissues
Authors: Y.H. Ling, Q. Quan, H. Xiang, L. Zhu, M.X. Chu, X.R. Zhang and C.Y. Han
Although RNA-Seq is an effective method for identifying and exploring novel functional genes in mammals, it has rarely been applied to study fertility-related genes in the goat. In this study, RNA-Seq was used to screen the estrus ovaries of uniparous and multiparous Anhui white goats (AWGs). In total, 15,890 genes were identified and 2201 of these were f.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.23
- DOI:
- 10.4238/2015.December.28.23
Pro domain peptide of HGCP-Iv cysteine proteinase inhibits nematode cysteine proteinases
Authors: Francine B. Silva, Jo�£o A.N. Batista, Brener M. Marra,Rodrigo R. Fragoso, Ana Carolina S. Monteiro, Edson L.Z. Figueira, and Maria F�¡tima Grossi-de-S�¡
Cysteine proteinases (CPs) are synthesized as zymogens and converted to mature proteinase forms by proteolytic cleavage and release of their pro domain peptides. A cDNA encoding a papain-like CP, called hgcp-Iv, was isolated from a Heterodera glycines J2 cDNA library, expressed and utilized to assess the ability of its propept.. Read More»
- Genet. Mol. Res. 3(3):