Expression
Johanson-Blizzard syndrome: a report of gender-discordant twins with a novel UBR1 mutation
Authors: C.R. Quaio, Y.K. Koda, D.R. Bertola, M. Sukalo, M. Zenker and C.A. Kim
Johanson-Blizzard syndrome (JBS) is a rare autosomal recessive disorder resulting from loss-of-function mutations in the UBR1 gene. JBS can be easily recognized by its unique clinical presentation (including exocrine pancreatic insufficiency, hypoplasia/aplasia of the alae nasi, congenital scalp defects, sensorineural hearing .. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.9.2
- DOI:
- http://dx.doi.org/10.4238/2014.June.9.2
Expression of 1alpha-HYD and 24-HYD in bovine kidney mediated by vitamin D3 supplementation
Authors: L.R. Rezende, E.F. Delgado, A.R.L. J�ºnior, G. Gasparin, E.C. Jorge, G.B. Mour�£o and L.L. Coutinho
order to better understand vitamin D3 in cattle metabolism, we quantified 1alpha-HYD and 24-HYD gene expression. In the kidneys of 35 male Nellore cattle, these were divided into a control group and two treatment groups (2 x 106 international units of vitamin D3 administered for 2 or 8 consecutive days pre-slaughter). Vitamin D3 supplementation resulted i.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.11.12
- DOI:
- 10.4238/2013.December.11.12
Overexpression of HSP27 in cultured human aortic smooth muscular cells reduces apoptosis induced by low-frequency and low-energy ultrasound by inhibition of an intrinsic pathway
Authors: B. Zhang, H.S. Zhou, Q. Cheng, L. Lei and B. Hu
We investigated in vitro the effect of low-frequency and low-energy ultrasound (LFLEU) on apoptosis of an overexpressed HSP27 human aortic smooth muscle cell (HASMC) line. A frequency of 42.6 kHz was used in all experiments. HASMC were exposed to ultrasound and cell viability was evaluated by MTT reduction. Overexpressed HSP27-HASMC was constructed on a p.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.11.10
- DOI:
- 10.4238/2013.December.11.10
A broad expression profile of the GMR-GAL4 driver in Drosophila melanogaster
Authors: W.-Z. Li, S.-L. Li, H.Y. Zheng, S.-P. Zhang and L. Xue
The GAL4/UAS binary system has been widely used in Drosophila melanogaster for ectopic expression of transgenes in a tissue-specific manner. The GMR-GAL4 driver, which expresses the yeast transcription factor GAL4 under the control of glass multiple reporter (GMR) promoter elements, has been commonly utilized to express target.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.6.4
- DOI:
- 10.4238/2012.August.6.4
Expression analysis of VfDGAT2 in various tissues of the tung tree and in transgenic yeast
Authors: Q.Q. Cui*, Y.C. Chen, X.J. Han, Z.Y. Zhan, L.Y. Lin, L.L. Si and Y.D. Wang
The tung tree (Vernicia fordii Hemsl.; Vf) has great potential as an industrial crop owning to its seed oil that has multiple uses. Diacylglycerol acyltransferases (DGATs) catalyze the last and most committed step of triacylglycerol (TAG) biosynthesis. In order to examine the physiological role of the VfDGAT2 gene in the tung tree, we characterized its ex.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.11.7
- DOI:
- 10.4238/2013.December.11.7
Relationship of common expression quantitative trait loci genes to the immune system
Authors: Relationship of common expression quantitative trait loci genes to the immune system
Tissue-specific expression quantitative trait loci (eQTLs) are always linked to specific diseases. In this study, we focused on eQTLs common to multiple tissues and explored their functional mechanisms in disease for the first time. We found 11 common eQTL genes among multiple tissues. Five genes were validated through a genome-wide association study, 3 g.. Read More»
- Genet. Mol. Res. 12(4):
Developmental characteristics of pectoralis muscle in Pekin duck embryos
Authors: L.H. Gu, T.S. Xu, W. Huang, M. Xie, W.B. Shi, S.D. Sun and S.S. Hou
To confirm the entire developmental process and transition point of embryonic Pekin duck pectoral muscle, and to investigate the association between pectoral muscle development and their regulating genes, anatomical and morphological analyses of embryonic Pekin duck skeletal muscles were performed, and the expression patterns of its regulating genes were .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.13.6
- DOI:
- 10.4238/2013.December.13.6
Gene expression and molecular modeling of the HSP104 chaperone of Trypanosoma cruzi
Authors: R.A. Campos, M.L. da Silva, G.V. da Costa, P.M. Bisch, J.M. Peralta, R. Silva, E. Rondinelli and T.P. ��rm�©nyi
Heat shock protein (HSP) 104 is a highly conserved molecular chaperone that catalyzes protein unfolding, disaggregation and degradation under stress conditions. We characterized HSP104 gene structure and expression in Trypanosoma cruzi, a protozoan parasite that causes Chagas’ disease. The T. cruzi HSP104 is an 869 amino-acid protein encoded by a si.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.6.15
- DOI:
- 10.4238/2012.August.6.15
Screening for genes that are differentially-expressed between gastric cancer cells and gastric tumor sphere cells using the gene chip technique
Authors: W.H. Shi, Y.B. Yu, Z.-Y. Li, X.-C. Guo, Z.-L. Wei and Z.-H. Zheng
The purpose of this study was to screen for genes that were differentially expressed between a human gastric carcinoma cell line (HGC-27) and their tumor spheres, using the gene chip technique. The HGC-27 cells and tumor sphere cells were cultured in vitro in a sterile environment. Total RNA was extracted from both sa.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.54
- DOI:
- 10.4238/2015.November.18.54
Cloning, sequence characterization, and expression patterns of members of the porcine TSSK family
Authors: P. Wang, H.L. Huo, S.Y. Wang, Y.W. Miao, Y.Y. Zhang, Q.L. Zhang, F.Q. Li, L.X. Liu, W.Z. Li, Y.Z. Zeng, J.L. Huo and H. Xiao
Testis-specific serine kinases (TSSKs) are a family of serine/threonine kinases highly expressed in the testes that are responsible for regulating many spermatogenesis-related protein activities. Mutations in this family have a positive relationship with oligospermia and azoospermia in human and mouse. Here, five members of th.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.18.56
- DOI:
- 10.4238/2015.October.18.56