Gene Expression
Study of the obp5 gene in Apis mellifera ligustica and Apis cerana cerana
Authors: H.X. Zhao, X.N. Zeng, Q. Liang, X.F. Zhang, W.Z. Huang, H.S. Chenand Y.X. Luo
Apis mellifera ligustica and A. cerana cerana exhibit differences in olfactory sensitivity to odors from nectariferous plants and diseased broods. It is presumed that the differences in odorant-binding proteins (OBPs) between these 2 species contribute to their olfactory sensitivity. We compared the sequences, temporal expression pattern, and binding prop.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.12.1
- DOI:
- 10.4238/2015.June.12.1
Molecular characterization of the myosatin gene and the effect of fasting on its expression in Chinese perch (Siniperca chuatsi)
Authors: L. Liu, Y.L. Li, S.D. Xu, K.Z. Wang, P. Wu, W.Y. Chu and X.Q. Wang
Myostatin (MSTN) is an important member of the transforming growth factor-β (TGF-β) superfamily and is a muscle growth inhibitor. In the present study, we cloned the Chinese perch MSTN cDNA sequence and analyzed its expression patterns under various conditions. The MSTN full cDNA sequence was 3347 bp long, including .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028354
- DOI:
- 10.4238/gmr.15028354
Branches of the NF-�ºB signaling pathway regulate proliferation of oval cells in rat liver regeneration
Authors: W.M. Zhao, Y.L. Qin, Z.P. Niu, C.F. Chang, J. Yang, M.H. Li, Y. Zhou and C.S. Xu1,
The NF-kB (nuclear factor kB) pathway is involved in the proliferation of many cell types. To explore the mechanism of the NF-kB signaling pathway underlying the oval cell proliferation during rat liver regeneration, the Rat Genome 230 2.0 Array was used to detect expression changes of NF-kB signaling pathway-related genes in .. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017750
- DOI:
- 10.4238/gmr.15017750
Partial least squares-based gene expression analysis in preeclampsia
Authors: F. Jiang, Y. Yang, J. Li, W. Li, Y. Luo, Y. Li, H. Zhao, X. Wang, G. Yin and G. Wu
Preeclampsia is major cause of maternal and fetal morbidity and mortality. Currently, the etiology of preeclampsia is unclear. In this study, we investigated differences in gene expression between preeclampsia patients and controls using partial least squaresbased analysis, which is more suitable than routine analysis. Expression profile data were downloa.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.2
- DOI:
- 10.4238/2015.June.18.2
Identification of a novel human testicular interstitial gene, RNF148, and its expression regulated by histone deacetylases
Authors: Y.Q. Liu, D.C. Tao, S.Y. Liao, Y. Yang, Y.X. Ma and S.Z. Zhang
Multiple genes are restrictively expressed in mammalian testicular tissues, and they play important roles in the complex process of spermatogenesis. Investigation of these genes and their expression regulation mechanisms is valuable to elucidate the molecular process of spermatogenesis. In this study, we identified a novel human gene, ring finger protein .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.27.7
- DOI:
- 10.4238/2013.September.27.7
Gene expression study related with the intrinsic pathway of apoptosis in bladder cancer by real-time PCR technique
Authors: D.F. Barione, F.S.N. Lizarte, P.C. Novais, C.A.M. de Carvalho, F.C.B. Valeri, F.M. Peria, H.F. de Oliveira, D.L. Zanette, W.A. Silva Jr., A.J. Cologna, R.B. Reis, S. Tucci Jr., A.C.P. Martins, D.P.C. Tirapelli and L.F. Tirapelli
We examined the expression of anti-apoptotic genes (XIAP and Bcl-2) and apoptotic genes (cytochrome c, caspase-9, Apaf-1) in tissue samples of patients with superficial bladder cancer. Thirty-two bladder cancer tissue samples (8 papillary urothelial neoplasm of low malignant potential, 10 low-grade, and 14 high-grade) and 8 normal bladder tissue samples f.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.4
- DOI:
- 10.4238/2013.April.2.4
Characteristic element of matrix attachment region mediates vector attachment and enhances nerve growth factor expression in Chinese hamster ovary cells
Authors: X.Y. Wang, J.H. Zhang, Q.L. Sun, Z.Y. Yao, B.G. Deng, W.Y. Guo,L. Wang, W.H. Dong, F. Wang, C.P. Zhao and T.Y. Wang
Preliminary studies have suggested that a characteristic element of the matrix attachment region (MAR) in human interferon-β mediates the adhesion of vectors to Chinese hamster ovary (CHO) cells. In this study, we investigated if vector adhesion increased nerve growth factor (NGF) expression in CHO cells. The MAR characteristic element sequence of hu.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.29
- DOI:
- 10.4238/2015.August.7.29
Effects of conjugated linoleic acid on the expression levels of miR-27 and miR-143 inpig adipose tissue
Authors: R.L. Qi, Y. Chen, J.X. Huang andF.Y. Yang
In this study, we evaluated the effect and possible mechanism of action of dietary conjugated linoleic acid (CLA) on pig body fat deposition. Landrace piglets (N = 48) were randomly divided into three groups, which were fed diets containing 0% (control), 1%, or 2% CLA. Dorsal and abdominal subcutaneous adipose tissues were collected, and real-time polymer.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.7
- DOI:
- 10.4238/2015.June.26.7
S-adenosylmethionine, a methyl donor, up regulates tissue inhibitor of metalloproteinase-2 in colorectal cancer
Authors: Z. Hussain, M.I. Khan, M. Shahid and F.N. Almajhdi
DNA methylation is a fundamental epigenetic mechanism in regulating the expression of genes controlling crucial cell functions in cancer development. Gene silencing via CpG island methylation/demethylation in the promoter region is one of the mechanisms by which different genes are inactivated/activated in human cancers. Tissue inhibitor of metalloprotein.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.10.6
- DOI:
- 10.4238/2013.April.10.6
Genome-wide identification and phylogenetic analysis of the AP2/ERF gene superfamily in sweet orange (Citrus sinensis)
Authors: T.M. Ito, P.B. Polido, M.C. Rampim, G. Kaschuk and S.G.H. Souza
Sweet orange (Citrus sinensis) plays an important role in the economy of more than 140 countries, but it is grown in areas with intermittent stressful soil and climatic conditions. The stress tolerance could be addressed by manipulating the ethylene response factor (ERF) transcription factors because they orchestrate .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.22
- DOI:
- 10.4238/2014.September.26.22