Gene Expression
Comparative study of leptin and leptin receptor gene expression in different swine breeds
Authors: S.E. Georgescu, M.A. Manea, S. Dinescu and M. Costache
Leptin is an important regulator of appetite, energy metabolism, and reproduction and is mainly synthesized in the adipocytes and then secreted into the bloodstream. The leptin receptor was classified as type I cytokine receptor due to its structural homology with IL-6 receptors and the signaling pathways in which they are bot.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.February.14.15
- DOI:
- 10.4238/2014.February.14.15
Molecular cloning and expression pattern of the DjStag gene in the planarian Dugesia japonica during embryonic development
Authors: Z.Q. Yuan, J.Y. Zhang and B.S. Zhao
We examined STAG-related gene (DjStag) expression in the planarian Dugesia japonica. This species is common in Far Eastern countries. The DjStag cDNA includes 1362 bp and contains a 489-bp open reading frame corresponding to a deduced protein of 162 amino acids, with a 170-bp 5'-UTR and a 703-bp 3'-UTR. Phylogenetic analysis s.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.10.10
- DOI:
- 10.4238/2014.January.10.10
Improvement in the carcass traits and meat quality of growing-finishing Rongchang pigs by conjugated linoleic acid through altered gene expression of muscle fiber types
Authors: J.X. Huang, R.L. Qi, X.L. Chen, X.Y. You, X.Q. Liu, F.Y. Yang and Z.H. Liu
A total of 160 Rongchang pigs (26.76 ± 1.78 kg) were randomly assigned to 5 dietary treatment groups until their body weight (BW) reached 90 kg. The diets were supplemented with 0, 0.5, 1.0, 1.5, and 2.0% conjugated linoleic acid (CLA). Our results showed that the 1.0 to 2.0% CLA-fed pigs had less back fat deposition wh.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.March.24.25
- DOI:
- 10.4238/2014.March.24.25
Identification and expression analysis of the Broad-Complex core protein isoform 6 (BR-C Z6) gene in the giant tiger shrimp Penaeus monodon (Penaeidae: Decapoda)
Authors: A. Buaklin, S. Klinbunga and P. Mensveta
Broad-Complex (BR-C) is an early ecdysone-responsive gene encoding a family of zinc-finger transcription factors that function during metamorphosis in insects. We identified two full-length cDNAs of BR-C Z6 in the giant tiger shrimp (Penaeus monodon). They were 2422 and 2060 bp in length, containing open reading frames of 1440.. Read More»
- Genet. Mol. Res. 10(4):
Effects of MMP-1 and MMP-3 gene polymorphisms on gene expression and protein level in lumbar disc herniation
Authors: B. Eser, O. Eser, Y. Yuksel, H. Aksit, E. Karavelioglu, M. Tosun and Z. Sekerci
The aim of this study was to identify the possible correlation between polymorphisms in matrix metalloproteinase (MMP)-1 and MMP-3 and their corresponding protein levels in disctissues obtained from patients with lumbar disc herniation (LDH) using biochemical and immunohistochemical analyses. Blood and disc samples were obtained from 100 patients with LDH.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038669
- DOI:
- 10.4238/gmr.15038669
A novel DDX5 gene in the freshwater crayfish Cherax quadricarinatus is highly expressed during ontogenesis and spermatogenesis
Authors: D.-A. Fang, Q. Wang1, J. Wang, L. He, L.-H. Liu and Y. Wang
The freshwater crayfish Cherax quadricarinatus, originally from Australia, is an invasive species that is also widely used in aquaculture. DEAD-box helicase family genes are found throughout evolution and encode RNA-binding proteins. The human DDX5 (p68) is important for normal cell growth, differentiation and proliferation. W.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.25.3
- DOI:
- 10.4238/2011.October.25.3
Regulation of human alpha-globin gene expression and alpha-thalassemia
Authors: D.M. Ribeiro and M.F. Sonati
Hemoglobin and globin genes are important models for studying protein and gene structure, function and regulation. We reviewed the main aspects of regulation of human α-globin synthesis, encoded by two adjacent genes (α2 and α1) clustered on chromosome 16. Their expression is controlled mainly by a regulatory element located 40 kb upstre.. Read More»
- Genet. Mol. Res. 7(4):
- vol7-4gmr472
- DOI:
- 10.4238/vol7-4gmr472
Conjugated linoleic acid-induced milk fat reduction associated with depressed expression of lipogenic genes in lactating Holstein mammary glands
Authors: L.Q. Han K. Pang H.J. Li S.B. Zhu L.F. Wang Y.B. Wang G.Q. Yang G.Y. Yang
The efficacy of conjugated linoleic acid (CLA) in diet supplements for milk fat reduction is well documented in several species. However, the mechanisms by which fatty acids regulate mammary lipogenesis remain largely unknown, especially with regard to gene expression of enzyme and regulators. In this study, 8 Holstein dairy cows in their mid-lactation pe.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.September.17.2
- DOI:
- 10.4238/2012.September.17.2
Screening and identification of peritoneal metastasis-related genes of gastric adenocarcinoma using a cDNA microarray
Authors: F.H. Bai, N.J. Wang, J. Wang, L. Yang, F.M. Zhang, F. Yin, J. Liang, K.C. Wu and D.M. Fan
With the aim of identifying peritoneal metastasis-related genes in gastric cancer, we performed a broad analysis of differential gene expression between the parental cell line GC9811 and its highly metastatic peritoneal counterpart, cell line GC9811-P. Two fluorescent cDNA probes, labeled with Cy3 and Cy5 dyes, were prepared f.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.June.25.1
- DOI:
- 10.4238/2012.June.25.1
Molecular cloning and expression analysis of TRAF3 in chicken
Authors: H.L. Yang, Z.Q. Feng, S.Q. Zeng, S.M. Li, Q. Zhu and Y.P. Liu
Tumor necrosis factor receptor-associated factor 3 (TRAF3) is a crucial regulator that suppresses c-Jun N-terminal kinase and non-canonical nuclear factor-kB signaling, but facilitates type I interferon production. To determine TRAF3 function in innate immune responses among birds, particularly chicken, we cloned and characterized the chicken TRAF3 gene (.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.April.30.14
- DOI:
- 10.4238/2015.April.30.14