Gene Expression
Application of MUTIC to the exploration of gene expression data in prostate cancer
Authors: Goertzel B, Pennachin C, Coelho LS and Mudado MA
We show here an example of the application of a novel method, MUTIC (model utilization-based clustering), used for identifying complex interactions between genes or gene categories based on gene expression data. The method deals with binary categorical data which consist of a set of gene expression profiles divided into two bi.. Read More»
- Genet. Mol. Res. 6(4):
Decreased MEFV gene expression in rheumatoid arthritis patients
Authors: E.O. Etem, S.S. Koca, D. Erol, S. Yolbas, E. Oz, H. Elyas and A. Is�±k
Rheumatoid arthritis (RA) is a major cause of adult chronic inflammatory arthritis and an autoimmune disease of unknown etiology in which the inflammatory pathology involves T cell activation. Genetic mutations in the Mediterranean fever (MEFV) gene, encoding pyrin, influence the severity of RA, but the underlying mechanisms are not completely understood... Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.6.3
- DOI:
- 10.4238/2015.February.6.3
Decoherence in yeast cell populations and its implications for genome-wide expression noise
Authors: M.R.S. Briones F. Bosco
Gene expression “noise” is commonly defined as the stochastic variation of gene expression levels in different cells of the same population under identical growth conditions. Here, we tested whether this “noise” is amplified with time, as a consequence of decoherence in global gene expression profiles (.. Read More»
- Genet. Mol. Res. 8(1):
- vol8-1gmr531
- DOI:
- 10.4238/vol8-1gmr531
Global gene expression profile in myelodysplastic syndromes using SAGE
Authors: C.F. Mendiburu, W.A. Silva Jr., O. Ricci Jr., C.R. Bonini-Domingos and A.C. Fett-Conte
The molecular pathogenesis of myelodysplastic syndromes (MDS) is poorly understood. In order to expand our knowledge of genetic defects in MDS, we determined the overall profile of genes expressed in bone marrow from patients with refractory anemia with excess blasts (RAEB) by serial analysis of gene expression (SAGE). The present report describes a parti.. Read More»
- Genet. Mol. Res. 7(4):
- vol7-4gmr521
- DOI:
- 10.4238/vol7-4gmr521
Transcriptional analysis of atrial and ventricular muscles from rats
Authors: Y. Zhi3*, Z. Cao2*, Q.H. Li1, X.L. Li1, Y. Sun1, T. Zhang1 and Q. Zhang1
Previous studies have used microarray technology to explore gene expression differences between the atrium and the ventricle. However, selection criteria for the differentially expressed genes (DEGs) based only on either the fold change or the P value in these studies. Here, we aim to further identify the DEGs by setting a P value threshold of 2, which ma.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017330
- DOI:
- 10.4238/gmr.15017330
Expression profiles of phosphatidylinositol phosphate kinase genes during normal human in vitro erythropoiesis
Authors: T.R. Zaccariotto C. Lanaro D.M. Albuquerque M.N.N. Santos M.A.C. Bezerra F.G.P. Cunha I. Lorand-Metze A.S. Araujo F.F. Costa M.F. Sonati
Phosphatidylinositol phosphate kinases (PIPKs) are enzymes that participate in diverse intracellular signaling pathways. They are classified into 3 functionally distinct subfamilies - PIPKI (a, b, g), PIPKII (a, b, g), and PIPKIII - located in various subcellular compartments. Recently, the PIPKIIa and b-globin genes were found to be overexpressed in reticul.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.November.12.3
- DOI:
- 10.4238/2012.November.12.3
Chemical synthesis and improved expression of recombinant human granulocyte colony-stimulating factor cDNA
Authors: S. Alrokayan
Recently, granulocyte colony-stimulating factor (G-CSF) has been recognized as a useful molecule for the treatment of a wide range of complex ailments, such as cancer, AIDS, H1N1 influenza, cardiac and neurological diseases. The vast therapeutic potential of G-CSF has induced scientists to develop biotechnological approaches f.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.31.18
- DOI:
- 10.4238/2011.October.31.18
Transcriptome analysis of skeletal muscle at prenatal stages in Polled Dorset versus Small-tailed Han sheep
Authors: N. Liu, J.N. He, W.M. Yu, K.D. Liu, M. Cheng, J.F. Liu, Y.H. He, J.S. Zhao and X.X. Qu
The objectives of the present study were to identify additional genes that may play important roles in the regulation of skeletal muscle growth and development, and to provide fundamental information for understanding the underlying molecular mechanisms. Eighteen cDNA libraries were constructed from the longissimus muscle of Polled Dorset (PD) and Small-t.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.6.12
- DOI:
- 10.4238/2015.February.6.12
Selection and validation of reference houseÃ?Âkeeping genes in the J774A1 macrophage cell line for quantitative real-time PCR
Authors: F.B. Ferraz and J.H. Fernandez
Macrophages are essential components of the innate and adaptive immune responses, playing a decisive role in atherosclerosis, asthma, obesity, and cancer. The differential gene expression resulting from adhesion of macrophages to the extra-cellular matrix (ECM) has been studied in the J774A1 murine macrophage cell line using quantitative polymerase chain .. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017720
- DOI:
- 10.4238/gmr.15017720
Transcriptome analysis of Arabidopsis seedlings responses to high concentrations of glucose
Authors: L. Han, J.L. Li, M. Jin and Y.H. Su
Sugars acting as fuel energy or as signaling molecules play important roles in plant growth and development. Although sugars associated with early seedling development have been analyzed in detail, few studies have examined the effect of sugar on genome-wide gene transcription. To analyze the role of glucose on the genomic level, we examined the response .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.11.11
- DOI:
- 10.4238/2015.May.11.11