Gene
Copy number imbalances detected with a BAC-based array comparative genomic hybridization platform in congenital diaphragmatic hernia fetuses
Authors: I.N. Machado, J.K. Heinrich, R. Barini and C.F.A. Peralta
Congenital diaphragmatic hernia (CDH) is a phenotypically and genetically heterogeneous disorder, with a complex inheritance pattern. Structural abnormalities of almost all chromosomes have been described in association with CDH. We made a molecular analysis through array comparative genomic hybridization (array CGH) of a grou.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr1001
- DOI:
- 10.4238/vol10-1gmr1001
Molecular markers located on the DGAT1, CAST, and LEPR genes and their associations with milk production and fertility traits in Holstein cattle
Authors: R. Hill, A. Canal, K. Bondioli, R. Morell and M.D. Garcia
The objective of the present study was to investigate single nucleotide polymorphisms (SNPs) located in three candidate genes previously reported to have effects on fertility and milk production traits in a population of 123 Holstein cows. The milk production traits evaluated included lifetime averages of milk yield, protein c.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017794
- DOI:
- 10.4238/gmr.15017794
Genetic diversity of the honeybee Apis cerana in Yunnan, China, based on mitochondrial DNA
Authors: L. Yin and T. Ji
DNA sequence diversity in the tRNAleu-COII portion of the mitochondrial genome was investigated in samples of Apis cerana from Yunnan, China. A fragment of about 480 bp in tRNAleu-COII, including a noncoding area and part of COII, was sequenced. The noncoding area was 97-98 bp; 8 haplotypes were found, among which 5 had been reported previously, while 3 w.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.20.1
- DOI:
- 10.4238/2013.June.20.1
Effects of cartilage-derived morphogenetic protein 1 (CDMP1) transgenic mesenchymal stem cell sheets in repairing rabbit cartilage defects
Authors: Y. Cui, M. Yao, Y. Liu, L. Mu, B. Zhang and G. Wu
The aim of this study was to investigate the abilities of cartilage-derived morphogenetic protein 1 (CDMP1) transgenic cell sheets in repairing rabbit cartilage defects. Rabbit CDMP1 transgenic bone marrow mesenchymal stem cell (BMSC) sheets (CDMP1-BMSCs) were cultured on temperature-sensitive culture dishes, and CDMP1 expression and type II collagen prot.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028058
- DOI:
- 10.4238/gmr.15028058
Development of microsatellite markers in Hagenia abyssinica (Bruce) J.F. Gmel, an endangered tropical tree of eastern Africa, using next-generation sequencing
Authors: A.W. Gichira, Z.C. Long, G.W. Hu, R.W. Gituru, Q.F. Wang and J.M. Chen
Hagenia abyssinica (Bruce) J.F. Gmel is an endangered tree species endemic to the high mountains of tropical Africa. We used Illumina paired-end technology to sequence its nuclear genome, aiming at creating the first genomic data library and developing the first set of genomic microsatellites. Seventeen microsatellite markers were validated in 24 individu.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028168
- DOI:
- 10.4238/gmr.15028168
Cobalt chloride induces metaphase when topically applied to larvae and pupae of the stingless bee Melipona scutellaris (Hymenoptera, Apidae, Meliponini)
Authors: C. Ueira-Vieira, R.R. Tavares, S. Morelli, B.B. Pereira, R.P. Silva, A.R. Torres-Mariano, W.E. Kerr and A.M. Bonetti
In order to optimize preparations of bee metaphases, we tested cobalt chloride, which has been used as a metaphase inducer in other organisms, such as hamsters and fish. Four microliters of 65 mM cobalt chloride aqueous solution was topically applied to larval and pupal stages of the stingless bee Melipona scutellaris. The cerebral ganglion was removed af.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.February.6.1
- DOI:
- 10.4238/2013.February.6.1
A network approach predicts NFKBIA and BIRC3 as pathogenic genes in childhood asthma
Authors: X.M. Gao
This study aimed to predict pathogenic genes of childhood asthma based on molecular interaction networks and gene expression data. Known pathogenic genes identified from the human protein-protein interaction network were denoted as seed genes, and were included in network A. We extracted sub-network B (pathogenic network), whi.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028226
- DOI:
- 10.4238/gmr.15028226
Genetic diversity of the Neotropical tree Hancornia speciosa Gomes in natural populations in Northeastern Brazil
Authors: H.J. Jimenez, L.S.S. Martins, A.V.V. Montarroyos, J.F. Silva Junior, A.L. Alzate-Marin and R.M. Moraes Filho
Mangabeira (Hancornia speciosa Gomes) is a fruit tree of the Apocynaceae family, which is native to Brazil and is a very important food resource for human populations in its areas of occurrence. Mangabeira fruit is collected as an extractive activity, and no domesticated varieties or breeding programs exist. Due to a reduction in the area of ecosystems wh.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.48
- DOI:
- 10.4238/2015.December.21.48
Correlation of androgen receptor and SRD5A2 gene mutations with pediatric hypospadias in 46, XY DSD children
Authors: X.H. Fu, W.Q. Zhang and X.S. Qu
We performed an exploratory study by analyzing the correlation of 46, XY disorders of sex development (46, XY DSD) with androgen receptor (AR) and steroid 5α-reductase-2 (SRD5A2) gene mutations and a safety analysis of dihydrotestosterone (DHT) gel treatment for pediatric micropenis. We collected samples from 76 pediatric patients with 46, XY DSD an.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15018232
- DOI:
- 10.4238/gmr.15018232
Effect of neural stem cell transplantation combined with erythropoietin injection on axon regeneration in adult rats with transected spinal cord injury
Authors: Y. Zhao, Y. Zuo, X.L. Wang, H.J. Huo, J.M. Jiang, H.B. Yan and Y.L. Xiao
We investigated the effect of neural stem cells (NSC) and erythropoietin (EPO) on axon regeneration in adult rats with transected spinal cord injury, and provided an experimental basis for clinical treatment. Forty Wistar rats with T10-transected spinal cord injury were randomly divided into four groups of ten rats: a control group (group A), an NSC-trans.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.4
- DOI:
- 10.4238/2015.December.22.4