Gene
Applying the Fisher score to identify Alzheimer�s disease-related genes
Authors: J. Yang, Y.L. Liu, C.S. Feng and G.Q. Zhu
Biologists and scientists can use the data from Alzheimer's disease (AD) gene expression microarrays to mine AD disease-related genes. Because of disadvantages such as small sample sizes, high dimensionality, and a high level of noise, it is difficult to obtain accurate and meaningful biological information from gene expressio.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028798
- DOI:
- 10.4238/gmr.15028798
Expression profiles of MMP-1 and TIMP-1 in lumbar intervertebral disc degeneration
Authors: B. Deng, J.Z. Ren, X.Q. Meng, C.G. Pang, G.Q. Duan, J.X. Zhang, H. Zou, H.Z. Yang and J.J. Ji
Lumbar intervertebral disc degeneration (IDD) is a common clinical pathology and has become a focus for research in recent years. Matrix metalloproteinases (MMPs) are enzymes responsible for the degradation of almost all extracellular matrix proteins (ECM). The over-expression of MMPs or tissue inhibitors of metalloproteinases (TIMPs) may disrupt the dyna.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.16
- DOI:
- 10.4238/2015.December.29.16
Antiviral effect of hepatitis B virus S/C gene loci antisense locked nucleic acid on transgenic mice in vivo
Authors: Y.B. Deng, H.J. Qin, Y.H. Luo, Z.R. Liang and J.J. Zou
We investigated the effects of hepatitis B virus (HBV) S/C double gene loci antisense locked nucleic acid on replication and expression of HBV in hepatitis transgenic mice. HBV mice (N = 30) were randomly divided into five groups of six mice: 5% glucose solution control, empty liposome control, single-target S, single-target C, and dual-target SC groups. .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.16
- DOI:
- 10.4238/2015.August.21.16
Identification and analysis of the TIFY gene family in Gossypium raimondii
Authors: D.H. He, Z.P. Lei, B.S. Tang, H.Y. Xing, J.X. Zhao and Y.L. Jing
The highly conserved TIFY domain is included in the TIFY protein family of transcription factors, which is important in plant development. Here, 28 TIFY family genes were identified in the Gossypium raimondii genome and classified into JAZ (15 genes), ZML (8), PPD (3), and TIFY (2). The normal (TIF[F/Y]XG) motif was dominant in the TIFY family, excluding .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.19
- DOI:
- 10.4238/2015.August.21.19
Differential expression of TLP, ERF1, and R2R3MYB in annual Medicago species under salinity conditions
Authors: F. Gharaghani, F. Rafiei, N. Mirakhorli and E. Ebrahimie
The present study was conducted to evaluate the responses of three annual Medicago species (M. truncatula, M. laciniata, and M. polymorpha) to salinity. We analyzed publicly available microarray data in NCBI pertaining to salinity-response genes in M. truncatula. Our data search identified Tubby C2 (TLP) and ethylene responsive transcription factor 1 (ERF.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.22
- DOI:
- 10.4238/2015.August.21.22
Transcriptomic differences of genes in the avian target of rapamycin (avTOR) pathway in a divergent line of meat-type chickens selected for feed efficiency
Authors: J. Lee and S.E. Aggrey
Avian target of rapamycin (avTOR) is a highly conserved serine-threonine kinase that serves as an intracellular energy and nutrient sensor and regulates cell division, growth, and apoptosis. The role of avTOR in mediating feed intake and growth in poultry is unknown. We studied avTOR signaling activities in duodenum and liver .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027120
- DOI:
- 10.4238/gmr.15027120
Investigation of genes in chronic and acute morphine-treated mice using microarray datasets
Authors: L. Ding, J.L. Zhang, S.H. Yu and L.F. Sheng
Morphine is a psychoactive medication that is used as a standard analgesic treatment to relieve pain in clinics. Many patients rely on chronic or acute treatment of morphine to treat pain. However, morphine is a narcotic and has a reverse effect when inappropriately used. Therefore, it is necessary to study chronic and acute morphine treatment to improve .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.3
- DOI:
- 10.4238/2015.August.28.3
Correlation between methylation of the E-Cadherin gene and malignancy of prostate cancer
Authors: S.Q. Zhang, G.Q. Zhang and L. Zhang
Prostate cancer is a common malignant tumor in males with an unclear pathogenic mechanism. As one epigenetic regulation mechanism, DNA methylation of the whole genome and specific gene(s) plays critical roles in pathogenesis, progression, diagnosis, and treatment of prostate cancer. The E-Cadherin gene is involved in cell meta.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028046
- DOI:
- 10.4238/gmr.15028046
Influence of the DCC gene on proliferation and carcinoembryonic antigen expression in the human colorectal cancer cell line SW1116
Authors: H.W. Jiang, J. Wang, H.J. Li, J.K. Peng, X.P. Gao and F. Chen
This study investigated the effects of stable transfection of the exogenous wild-type DCC gene on growth of the human colorectal carcinoma cell line SW1116 in vitro. The DCC gene was amplified from normal human colon tissue by reverse transcription-polymerase chain reaction and used to construct a recombinant expression plasmid, pcDNA3.1(+)-DCC. DCC-negat.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.12
- DOI:
- 10.4238/2015.August.28.12
Investigation of single nucleotide polymorphisms in phosphodiesterase 4D gene in Mongol and Han patients with ischemic stroke in Inner Mongolia
Authors: J.P. Shi, W.D. Chen, J.Q. Zhou, M.M. Xue, F. Xue, H.Z. Li and Z.P. Xu
We investigated single nucleotide polymorphisms (SNP) at 87 sites of the phosphodiesterase 4D (PDE4D) gene in Mongol and Han patients with ischemic stroke in Inner Mongolia. SNPs in 226 patients with ischemic stroke (case group, 110 Mongol patients, 116 Han patients) and 220 patients without neurological disease (control group, 102 Mongol patients, 118 Ha.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.13
- DOI:
- 10.4238/2015.August.28.13