Gene
A single nucleotide polymorphism in NEUROD1 is associated with production traits in Nelore beef cattle
Authors: P.S.N. de Oliveira, P.C. Tizioto, W. Malago Jr, M.L. do Nascimento, A.S.M. Cesar, W.J.S. Diniz, M.M. de Souza, D.P.D. Lanna, R.R. Tullio, G.B. Mour�£o, M. de A. Mudadu, L.L. Coutinho and L.C. de A. Regitano
Feed efficiency and carcass characteristics are late-measured traits. The detection of molecular markers associated with them can help breeding programs to select animals early in life, and to predict breeding values with high accuracy. The objective of this study was to identify polymorphisms in the functional and positional .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028161
- DOI:
- 10.4238/gmr.15028161
Effect of IL-17 monoclonal antibody Secukinumab combined with IL-35 blockade of Notch signaling pathway on the invasive capability of hepatoma cells
Authors: H.CH. Li, Y.X. Zhang, Y. Liu and Q.SH. Wang
We investigated the effect of the IL-17 monoclonal antibody Secukinumab combined with IL-35 in the blockade of the Notch signaling pathway on the invasive capability of hepatoma cells. We examined the effects of IL-17 antibody or IL-35 treatment alone or in combination on cell invasion and migration capabilities with Transwell.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028174
- DOI:
- 10.4238/gmr.15028174
Molecular-level effects of eribulin and paclitaxel on breast cancer based on differential co-expression network analysis
Authors: J. Qin and Y.H. Chen
We investigated the effects of eribulin and paclitaxel on breast cancer (BC) by exploring molecular biomarkers and pathways. Co-expression networks were constructed by differentially co-expressed genes and links, and centralities were analyzed to explore the hub genes. Pathway-enrichment analysis was performed. The hub genes w.. Read More»
- Genet. Mol. Res. 15(2):
Complete mitochondrial genome sequence and gene organization of Chinese indigenous chickens with phylogenetic considerations
Authors: F.P. Zhao, H.Y. Fan, G.H. Li and B.K. Zhang
In this study, we sequenced the complete mitochondrial DNA of Chinese indigenous Jinhu Black-bone and Rugao chickens. The two chicken mitochondrial genomes were deposited in GenBank under accession Nos. KP742951 and KR347464, respectively. The complete mitochondrial genomes of Jinhu Black-bone and Rugao chickens were sequenced.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028200
- DOI:
- 10.4238/gmr.15028200
Association of genetic variations in the ACLY gene with growth traits in Chinese beef cattle
Authors: M.N. Li, X. Guo, P.J. Bao, X.Y. Wu, X.Z. Ding, M. Chu, C.N. Liang and P. Yan
ATP citrate lyase (ACLY) is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA, which is a key precursor of both fatty acid and mevalonate synthesis pathways. Genetic variation of the ACLY gene may influence multiple traits associated with animal production. Here, we identified three non-synonymous mutati.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028250
- DOI:
- 10.4238/gmr.15028250
Splicing mutation of a gene within the Duchenne muscular dystrophy family
Authors: Y.B. Zhu, J.H. Gan, J.W. Luo, X.Y. Zheng, S.C. Wei and D. Hu
The aim of this study was to identify the mutation site and phenotype of the Duchenne muscular dystrophy (DMD) gene in a DMD family. The DMD gene is by far the largest known gene in humans. Up to 34% of the point mutations reported to date affect splice sites of the DMD gene. However, no hotspot mutation has been reported. Cap.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028258
- DOI:
- 10.4238/gmr.15028258
Complete mitochondrial genome of the Liuyang black goat and its phylogenetic relationship with other Caprinae
Authors: S. Chen, H.M. Ma, G.S. Chen and L.Y. Wang
In this study, the complete mitochondrial genome sequence of the Liuyang black goat was investigated, and phylogenetic relationships between the Liuyang black goat and other species of Caprinae were analyzed. The total length of the mitochondrial genome was 16,715 bp, which consisted of 33.50% A, 27.27% T, 25.98% C, and 13.25%.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028267
- DOI:
- 10.4238/gmr.15028267
Genetic effect of an A/G polymorphism in the HSP70 gene on thermotolerance in chicken
Authors: Z.Y. Chen, W.W. Zhang, J.K. Gan, L.N. Kong, X.Q. Zhang,D.X. Zhang and Q.B. Luo
Studying thermotolerance is important for the prevention of thermostress in chickens. This study aimed to analyze the effect of mutations in the heat shock protein 70 (HSP70) gene on chicken thermotolerance. The C.-69A>G SNP in the 5'-flanking region of the HSP70 gene was genotyped in Lingshan and White Recessive Rock (WRR).. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028271
- DOI:
- 10.4238/gmr.15028271
Exome sequencing in Thai patients with familial obesity
Authors: S. Kaewsutthi, J. Santiprabhob, B. Phonrat, A. Tungtrongchitr,P. Lertrit and R. Tungtrongchitr
Obesity is a major worldwide health issue, with increasing prevalence in adults and children from developed and developing countries. Obesity causes several chronic diseases, including cardiovascular and respiratory diseases, osteoarthritis, hypertension, stroke, type II diabetes, obstructive sleep apnea, and several types of .. Read More»
- Genet. Mol. Res. 15(2):
Comparative sequence and expression analysis of tapetum specific male sterility related genes in Medicago truncatula
Authors: L.H. Shao, X.W. Zheng, D.X. Yi and C. Li
Heterosis, or enhancement through outbreeding, is one of the most promising approaches for increasing crop yield. Male sterility (MS), which promotes heterosis, has been widely applied in hybrid crop production. Medicago truncatula is a model legume species and is closely related to M. sativa, an important legume forage plant... Read More»
- Genet. Mol. Res. 15(2):