Gene
Expression profiles of differentially expressed genes affecting fecundity in goat ovarian tissues
Authors: Y.H. Ling, Q. Quan, H. Xiang, L. Zhu, M.X. Chu, X.R. Zhang and C.Y. Han
Although RNA-Seq is an effective method for identifying and exploring novel functional genes in mammals, it has rarely been applied to study fertility-related genes in the goat. In this study, RNA-Seq was used to screen the estrus ovaries of uniparous and multiparous Anhui white goats (AWGs). In total, 15,890 genes were identified and 2201 of these were f.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.23
- DOI:
- 10.4238/2015.December.28.23
Association between MTHFR gene polymorphisms (C677T, A1298C) and genetic susceptibility to prostate cancer: a meta-analysis
Authors: P.L. Chen, W.T. Li, J. Wang, Y.D. Jiang, P. Wu, T. Chen and S.B. Zheng
Genetic polymorphisms (C677T and A1298C) in methylenetetrahydrofolate reductase (MTHFR) were shown to be related to prostate cancer risk in previous studies; however, the results are controversial. We performed a meta-analysis of previous studies and quantitatively estimated these associations. Pubmed, Embase, and Cochrane Library Database were searched f.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.29
- DOI:
- 10.4238/2015.December.29.29
Repeatability of agronomic traits in Panicum maximum (Jacq.) hybrids
Authors: T.G.S. Braz, D.M. Fonseca, L. Jank, C.D. Cruz and J.A. Martuscello
When evaluating plants, in particular perennial species, it is common to obtain repeated measures of a given trait from the same individual to evaluate the traits’ repeatability in successive harvests. The degree of correlation among these measures defines the coefficient of repeatability, which has been widely utilized in the study of forage traits.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.38
- DOI:
- 10.4238/2015.December.29.38
Association between the AGTR1 A1166C polymorphism and risk of IgA nephropathy: a meta-analysis
Authors: J.M. Xu, X. Song, F. Gao and R. Wang
Numerous studies have evaluated the association between the A1166C polymorphism in the angiotensin II type 1 receptor (AGTR1) gene and immunoglobulin A nephropathy (IgAN) risk. However, this relationship remains controversial. Our aim was to evaluate the relationship between this polymorphism and IgAN susceptibility by performing a meta-analysis. Articles.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.47
- DOI:
- 10.4238/2015.December.29.47
Public sphere and the sustainability of the bioinformatics promise
Authors: Marcelo Leite
The literature about genomics and bioinformatics achievements in high-impact journals such as Nature and Science has raised disproportionate expectations amongst the general public about fast and revolutionary drugs and breakthroughs in biomedicine. However, the yield obtained by database mining activities has been modest, as .. Read More»
- Genet. Mol. Res. 3(4):
Splicing factors are differentially expressed in tumors
Authors: Natanja Kirschbaum-Slager, Graziela M.P. Lopes, Pedro A.F. Galante, Gregory J. Riggins and Sandro J. de Souza
Although alternative splicing of many genes has been found associated with different stages of tumorigenesis and splicing variants have been characterized as tumor markers, it is still not known whether these examples are sporadic or whether there is a broader association between the two phenomena. In this report we evaluated,.. Read More»
- Genet. Mol. Res. 3(4):
Comparative analysis of noncoding sequences of orthologous bovine and human gene pairs
Authors: Melissa Nunes Miziara, Penny K. Riggs and M. Elisabete J. Amaral
Genomic sequence comparison across species has enabled the elucidation of important coding and regulatory sequences encoded within DNA. Of particular interest are the noncoding regulatory sequences, which influence gene transcriptional and posttranscriptional processes. A phylogenetic footprinting strategy was employed to iden.. Read More»
- Genet. Mol. Res. 3(4):
Reduction of non-digestible oligosaccharides in soy milk: application of engineered lactic acid bacteria that produce �±-galactosidase
Authors: Jean Guy LeBlanc, Aurelio Silvestroni, Cristelle Connes,Vincent Juillard, Graciela Savoy de Giori, Jean-Christophe Piard and Fernando Sesma
Human consumption of soy-derived products has been limited by the presence of non-digestible oligosaccharides (NDO), such as the a-galactooligosaccharides raffinose and stachyose. Most mammals, including man, lack pancreatic a-galactosidase (a-Gal), which is necessary for the hydrolysis of these sugars. However, such NDO can b.. Read More»
- Genet. Mol. Res. 3(3):
Oncogene-induced transcriptional patterns in established cell lines as a model for in vitro analysis of tumor biology
Authors: Francisco de Paula Careta, Bruno Marcos Verbeno Azevedo,Beatriz Alves Vianna1, Greiciane Gaburro Paneto,Irineu Iester Degasperi, Marcos do Carmo Oyama,Val�©ria Fagundes, ��ngela Maria Spagnol Perrone andI�ºri Drumond Louro
Established cell lines have long been used for in vitro studies of tumor biology, enabling investigators to control growth conditions and to draw important conclusions about the oncogenic microenvironment. However, gene expression behavior in cultured cells may not always reflect the actual in vivo scenario, and analysis deriv.. Read More»
- Genet. Mol. Res. 3(3):
The potential of virus-induced gene silencing for speeding up functional characterization of plant genes
Authors: Vagner A. Benedito, Peter B. Visser, Gerco C. Angenent and Frans A. Krens
Virus-induced gene silencing (VIGS) has been shown to be of great potential in plant reverse genetics. Advantages of VIGS over other approaches, such as T-DNA or transposon tagging, include the circumvention of plant transformation, methodological simplicity and robustness, and speedy results. These features make VIGS an attra.. Read More»
- Genet. Mol. Res. 3(3):