Gene
Association between the AGTR1 A1166C polymorphism and risk of IgA nephropathy: a meta-analysis
Authors: J.M. Xu, X. Song, F. Gao and R. Wang
Numerous studies have evaluated the association between the A1166C polymorphism in the angiotensin II type 1 receptor (AGTR1) gene and immunoglobulin A nephropathy (IgAN) risk. However, this relationship remains controversial. Our aim was to evaluate the relationship between this polymorphism and IgAN susceptibility by performing a meta-analysis. Articles.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.47
- DOI:
- 10.4238/2015.December.29.47
Public sphere and the sustainability of the bioinformatics promise
Authors: Marcelo Leite
The literature about genomics and bioinformatics achievements in high-impact journals such as Nature and Science has raised disproportionate expectations amongst the general public about fast and revolutionary drugs and breakthroughs in biomedicine. However, the yield obtained by database mining activities has been modest, as .. Read More»
- Genet. Mol. Res. 3(4):
Splicing factors are differentially expressed in tumors
Authors: Natanja Kirschbaum-Slager, Graziela M.P. Lopes, Pedro A.F. Galante, Gregory J. Riggins and Sandro J. de Souza
Although alternative splicing of many genes has been found associated with different stages of tumorigenesis and splicing variants have been characterized as tumor markers, it is still not known whether these examples are sporadic or whether there is a broader association between the two phenomena. In this report we evaluated,.. Read More»
- Genet. Mol. Res. 3(4):
Comparative analysis of noncoding sequences of orthologous bovine and human gene pairs
Authors: Melissa Nunes Miziara, Penny K. Riggs and M. Elisabete J. Amaral
Genomic sequence comparison across species has enabled the elucidation of important coding and regulatory sequences encoded within DNA. Of particular interest are the noncoding regulatory sequences, which influence gene transcriptional and posttranscriptional processes. A phylogenetic footprinting strategy was employed to iden.. Read More»
- Genet. Mol. Res. 3(4):
Reduction of non-digestible oligosaccharides in soy milk: application of engineered lactic acid bacteria that produce �±-galactosidase
Authors: Jean Guy LeBlanc, Aurelio Silvestroni, Cristelle Connes,Vincent Juillard, Graciela Savoy de Giori, Jean-Christophe Piard and Fernando Sesma
Human consumption of soy-derived products has been limited by the presence of non-digestible oligosaccharides (NDO), such as the a-galactooligosaccharides raffinose and stachyose. Most mammals, including man, lack pancreatic a-galactosidase (a-Gal), which is necessary for the hydrolysis of these sugars. However, such NDO can b.. Read More»
- Genet. Mol. Res. 3(3):
Oncogene-induced transcriptional patterns in established cell lines as a model for in vitro analysis of tumor biology
Authors: Francisco de Paula Careta, Bruno Marcos Verbeno Azevedo,Beatriz Alves Vianna1, Greiciane Gaburro Paneto,Irineu Iester Degasperi, Marcos do Carmo Oyama,Val�©ria Fagundes, ��ngela Maria Spagnol Perrone andI�ºri Drumond Louro
Established cell lines have long been used for in vitro studies of tumor biology, enabling investigators to control growth conditions and to draw important conclusions about the oncogenic microenvironment. However, gene expression behavior in cultured cells may not always reflect the actual in vivo scenario, and analysis deriv.. Read More»
- Genet. Mol. Res. 3(3):
The potential of virus-induced gene silencing for speeding up functional characterization of plant genes
Authors: Vagner A. Benedito, Peter B. Visser, Gerco C. Angenent and Frans A. Krens
Virus-induced gene silencing (VIGS) has been shown to be of great potential in plant reverse genetics. Advantages of VIGS over other approaches, such as T-DNA or transposon tagging, include the circumvention of plant transformation, methodological simplicity and robustness, and speedy results. These features make VIGS an attra.. Read More»
- Genet. Mol. Res. 3(3):
Cytogenetics of genetic counseling patients in Pelotas, Rio Grande do Sul, Brazil
Authors: A.C. Duarte1, E. Cunha, J.M. Roth, F.L.S. Ferreira, G.L. Garcias and M.G. Martino-Roth
From 1986 to 2002, we examined the chromosomal composition of 916 patients attended by two genetic counseling services in the city of Pelotas, in the Brazilian State of Rio Grande do Sul, to determine the genetic causes of their disturbances. Patterns of G-banding using trypsin and Giemsa (GTG) and C-banding using barium and G.. Read More»
- Genet. Mol. Res. 3(3):
Comparative cytogenetic studies of Curimatidae (Pisces, Characiformes) from the middle Paran�¡ River (Argentina)
Authors: M.S. Brassesco, M.C. Pastori, H.A. Roncati and A.S. Fenocchio
Almost all species of the Curimatidae family have a stable karyotype, with a diploid number of 54 metacentric (M) and submetacentric (SM) chromosomes, and one sole nucleolus organizer pair. This family has considerable specific diversity in Argentinean fluvial basins; however, no cytogenetic data are available. Eight species f.. Read More»
- Genet. Mol. Res. 3(2):
Evolution by polyploidy and gene regulation in Anura
Authors: Maria Luiza Be�§ak, Leonardo Setsuo Kobash
The evolution of the metazoa has been characterized by gene redundancy, generated by polyploidy, tandem duplication and retrotransposition. Polyploidy can be detected by looking for duplicated chromosomes or segments of orthologous chromosomes in post-polyploid animals. It has been proposed that the evolutionary role of polypl.. Read More»
- Genet. Mol. Res. 3(2):