Gene
Genetic, biochemical, and anatomic characterization of neurological mutant 3, a new mouse model for Parkinsonâ??s disease
Authors: Marie E. Legare, William H. Hanneman
We have identified a new mutant mouse that we have named new mouse neurological mutant 3 (NM3); it may be a useful model to understand the underlying molecular and genetic basis of Parkinson’s disease (PD). A mouse carrying the NM3 mutation arose spontaneously in an RIIIS/J breeding colony and was identified as having a .. Read More»
- Genet. Mol. Res. 2(3):
Cassava, Manihot esculenta Crantz genetic resources: VI. Anatomy of a diversity center
Authors: N.M.A. Nassar
Central Brasil is one of the four centers of diversity of Manihot species. Of 26 wild Manihot species reported to occur in this region, 20 were collected from two limited areas, each less than 100 km in diameter. These two areas are Goiás Velho and Corumbá de Goiás. Considering the Harlan concept of geogra.. Read More»
- Genet. Mol. Res. 2(2):
Stage-specific gene expression during Trypanosoma cruzi metacyclogenesis
Authors: Andr?©a Rodrigues ?vila, Bruno Dallagiovanna, Sueli Fumie Yamada-Ogatta, Viviane Monteiro-G?³es, St?ªnio Perdig?£o Fragoso Marco Aur?©lio Krieger, Samuel Goldenberg
The process of Trypanosoma cruzi metacyclogenesis involves the transformation of noninfective epimastigotes into metacyclic trypomastigotes, which are the pathogenic form. The analysis of stage-specific genes during T. cruzi metacyclogenesis may provide insight into the mechanisms involved in the regulation of gene expression .. Read More»
- Genet. Mol. Res. 2(1):
Control of gene expression and genetic manipulation in the Trypanosomatidae
Authors: Santuza M.R. Teixeira, Wanderson D. da Rocha
Mechanisms controlling gene expression in trypanosomatids depend on several layers of regulation, with most regulatory pathways acting at a post-transcriptional level. Consequently, these parasites can follow the rapid changes associated with transitions between the insect vector and the mammalian host, with instant reprogramm.. Read More»
- Genet. Mol. Res. 2(1):
Sex in fungi: lessons of gene regulation
Authors: Cristina A.J. Souza, Carla C. Silva, Adlane V.-B. Ferreira
Fungi have been very useful for gene regulation studies. Mating implicates in a series of events influenced by many types of environmental input that are interpreted into regulatory pathways, including signal transduction. Although various aspects of mating and signal transduction in the yeast Saccharomyces cerevisiae have lon.. Read More»
- Genet. Mol. Res. 2(1):
Molecular epidemiology of the hepatitis C virus in Brazil
Authors: Solange Busek, Guilherme Oliveira
Hepatitis C virus (HCV) is a major cause of liver disease throughout the world. The genome of this virus consists of approximately 10,000 bp and codes for 10 mature polypeptides. Genome sequence comparison has revealed the existence of six major genotypes and a large number of subtypes. The genotypes can be distinguished by wh.. Read More»
- Genet. Mol. Res. 2(1):
RAPD analysis of herbicide-resistant Brasilian rice lines produced via mutagenesis
Authors: S.S. Sandhu, C?¢ndido R. Bastos, Luiz Ernesto Azini, Augusto Tulmann Neto, Carlos Colombo
Over the last two decades, mutational techniques have become one of the most important tools available to progressive rice- breeding programs. In a mutation-breeding program initiated in 1999 at the Instituto Agronômico of Campinas, SP, Brazil, a rice line, IAC103, was selected for mutational studies with gamma radiation.. Read More»
- Genet. Mol. Res. 1(4):
Intraspecific variability of Bipolaris sorokiniana isolates determined by random-amplified polymorphic DNA (RAPD)
Authors: Aida T.S. Matsumura, Ariano M. Prestes, Sueli T. Van Der Sand, Andr?©ia M.R. de Oliveir
Isolates of Bipolaris sorokiniana were analyzed by random-amplified polymorphic DNA (RAPD) techniques to determine the amount of intraspecific genetic variability and to study host-pathogen interactions. Ten isolates originated from different regions of Brazil were examined. Plants of the wheat cultivars BR8, BH1146 (original .. Read More»
- Genet. Mol. Res. 1(4):
Growth hormone mRNA expression in the pituitary of Bos indicus and Bos taurus x Bos indicus crossbred young bulls treated with recombinant bovine somatotropin
Authors: S.M.Z. Di Mauro, L.R. Furlan, M.I.T. Ferro, M. Macari andJ.A. Ferro
The effects of breed and of recombinant bovine somatotropin (rbST) treatment on growth hormone gene expression were studied in young bulls. The experiment was completely randomized in a [2 x 2]-factorial arrangement, using two levels of rbST (0 or 250 mg/animal/14 days), and two breed groups (Nelore and Simmental x Nelore cros.. Read More»
- Genet. Mol. Res. 1(4):
Ectodermal dysplasias (group A): elaborationof a computerized database to help withgenetic-clinical diagnosis(Displasias ectod?©rmicas do grupo A:elabora?§?£o de um banco de dadosinformatizado para aux?lio ao diagn?³sticogen?©tico-cl?nico)
Authors: Toni Lisboa Costa
Ectodermal dysplasias are conditions that involve structures derived from the ectoderm, such as the epidermis and its enclosures, constituting a large and complex nosologic group, composed of rare entities with genetic etiology (in their majority). Freire-Maia, in 1971 and 1977, proposed a clinical definition and a clinical-mn.. Read More»
- Genet. Mol. Res. 1(3):