Genetic Polymorphism
Association between IL-1�± rs17561 and IL-1�² rs1143634 polymorphisms and periodontitis: a meta-analysis
Authors: W.T. Yin, Y.P. Pan and L. Lin
Genetic variations in human interleukin-1 (IL-1) genes are known to be involved in inflammatory disorders. The rs17561 and rs1143634 polymorphisms of IL-1α and IL-1β, respectively, have been increasingly recognized as important regulators in the development of periodontitis. However, the existence of a specific association remains controversial.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017325
- DOI:
- 10.4238/gmr.15017325
Diversity of platelet function and genetic polymorphism in clopidogrel-treated Chinese patients
Authors: B. Sun, J. Li, M. Dong, L. Yang, C. Wu, L. Zhu and Y.L. Cong
We investigated the correlation between genetic polymorphisms of cytochrome P450 enzyme genes and the outcome of clopidogrel treatment in 118 coronary disease patients after percutaneous coronary intervention at the Chinese PLA General Hospital. Patients were divided into an ischemia event relapse group (IERG) and a non-IERG group (NIERG) based on relapse.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.22
- DOI:
- 10.4238/2015.February.13.22
An investigation of the relationship between serotonin transporter gene promoter polymorphism and psoriasis susceptibility in a Thai population
Authors: T. Tencomnao and J. Wongpiyabovorn
The serotonin transporter (5-HTT) is of great significance in the control of the serotonergic system, and its expression is known to be upregulated in psoriasis, a chronic or recurrent inflammatory skin disease. We investigated a possible association between the 5-HTT gene-linked polymorphic region (5-HTTLPR) and psoriasis in .. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr920
- DOI:
- 10.4238/vol9-4gmr920
Prevalence of CCR5-Ã?Â?32 and CCR2-V64I polymorphisms in a mixed population from northeastern Brazil
Authors: H. Ferreira-Fernandes, A.C.C. Santos, F.J.N. Motta, R. Canalle, F.K.N. Yoshioka, R.R. Burbano, J.A. Rey, B.B. da Silva and G.R. Pinto
Chemokines are low-molecular weight proteins that play a key role in inflammatory processes. Genomic variations in chemokine receptors are associated with the susceptibility to various diseases. Polymorphisms in chemokine receptor type 5 (CCR5)-Δ32 and CCR2-V64I are related to human immunodeficiency virus infection resis.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.2.4
- DOI:
- 10.4238/2015.October.2.4
Frequency of ABO blood group system polymorphisms in Plasmodium falciparum malaria patients and blood donors from the Brazilian Amazon region
Authors: D.B. Carvalho, L.C. de Mattos, W.C. Souza-Neiras, C.R. Bonini-Domingos, A.B. C�³simo, L.M. Storti-Melo, G.C. Cassiano, A.A.A. Couto, A.J. Cordeiro, A.R.B. Rossit and R.L.D. Machado
We investigated the ABO genotypes and heterogeneity of the O alleles in Plasmodium falciparum-infected and non-infected individuals from the Brazilian Amazon region. Sample collection took place from May 2003 to August 2005, from P. falciparum malaria patients from four endemic regions of the Brazilian Amazon. The control grou.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr803
- DOI:
- 10.4238/vol9-3gmr803
Association between peroxisome proliferator-activated receptor gamma coactivator-1 alpha polymorphism and hypertension in Mongolians in Inner Mongolia
Authors: X.L. Su, H.R. Dong, M.R. Yan, H.W. Cui, L. Yang and F.Q. Han
We investigated a possible association of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) Gly482Ser polymorphism with hypertension in Mongolians in Inner Mongolia. A total of 787 subjects were enrolled randomly, including 390 hypertension patients and 397 healthy controls. Triglycerides, cho.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.12.2
- DOI:
- 10.4238/2011.December.12.2
Genetic polymorphism in sex hormone metabolism and prostate cancer risk
Authors: E. Ersekerci, M. Sofikerim, S. Taheri, A. Demirtas and F. Halis
We compared single-nucleotide polymorphisms for point mutations in cytochrome P450 genes, including cytochrome P450c17α (CYP17), cytochrome P450 aromatase (CYP19), steroid-5-a-reductase (SRD5A2), and prostate-specific antigen (PSA) involved in androgen and estrogen production. Between January 2008 and January 2010, 90 patients were enrolled in the s.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.8
- DOI:
- 10.4238/2015.July.3.8
Association between PARK16 gene polymorphisms and susceptibility of Parkinson�s disease in a Chinese population
Authors: H. Xia, Q. Luo, X.X. Li and X.L. Yang
Recent genome-wide association studies identified 11 risk loci in different populations of familial and sporadic Parkinson’s disease (PD) patients. Few loci have been verified in different European and Asian populations. We also validated 2 new single-nucleotide polymorphisms, rs947211 and rs823144, in PARK16 to explore their association with suscep.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.7
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.7
Genetic polymorphisms of cytochrome P450 enzymes 2C9 and 2C19 in a healthy Mongolian population in China
Authors: Z.F. Yang, H.W. Cui, T. Hasi, S.Q. Jia, M.L. Gong and X.L. Su
We examined the distribution of major allelic variants of CYP2C9 and CYP2C19 in the Mongolian population of China and compared it with that of other populations. The polymorphisms of CYP2C9 (including the CYP2C9*1, CYP2C9*2 and CYP2C9*3 alleles) and CYP2C19 (including the CYP2C19*1, CYP2C19*2 and CYP2C19*3 alleles) were analyz.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr938
- DOI:
- 10.4238/vol9-3gmr938
Personalized diagnosis by cached solutions with hypertension as a study model
Authors: P.C. Carvalho, S.S. Freitas, A.B. Lima, M. Barros, I. Bittencourt, W. Degrave, I. Cordovil, R. Fonseca, M.G.C. Carvalho, R.S. Moura Neto and P.H. Cabello
Statistical modeling of links between genetic profiles with environmental and clinical data to aid in medical diagnosis is a challenge. Here, we present a computational approach for rapidly selecting important clinical data to assist in medical decisions based on personalized genetic profiles. What could take hours or days of .. Read More»
- Genet. Mol. Res. 5(4):