Genetic Polymorphism

Decreased risk of developing lung cancer in subjects carrying the CLPTM1L rs401681 (G>A) polymorphism: evidence from a meta-analysis

Authors: X.L. Zhang, X.J. Zhang, Y. Chen, Y.M. Zhang, Q. Zhang,C.X. Cao, D.Y. Gu, J.F. Shi, Y.L. Gong, J.F. Chen and C.J. Tang

A genome-wide association study revealed that a single nucleotide polymorphism, CLPTM1L - rs401681 (G>A), located at the 5p15.33 locus was signifi cantly associated with increased risk of various cancers; however, its association with lung cancer is currently inconclusive. In order to explore the relationship between this p.. Read More»

Genet. Mol. Res. 13(1):

http://dx.doi.org/2014.February.28.10

DOI:

http://dx.doi.org/10.4238/2014.February.28.10

Association between genetic polymorphisms of PTGS2 and glioma in a Chinese population

Authors: R.P. Lin, C.Y. Yao and D.X. Ren

Several previous studies indicated that genetic polymorphisms in inflammatory factor genes were associated with glioma risk. However, the relationship between the prostaglandin-endoperoxide synthase 2 (PTGS2) genetic polymorphism and glioma remains unclear in the Chinese population. We selected 199 histologically confirmed adult glioma patients and 199 ca.. Read More»

Genet. Mol. Res. 14(2):

http://dx.doi.org/2015.April.10.25

DOI:

http://dx.doi.org/10.4238/2015.April.10.25

TNFR1 -383 AÃ?Â?C polymorphism and ankylosing spondylitis in a Russian Caucasian population: a preliminary study

Authors: V. Mordovskii, A. Semenchukov, S.Y. Nikulina, A.B. Salmina, A. Chernova, E. Kapustina, A. Kents, A. Ohapkina, E. Moskaleva, P.E. Maltese, P. Convertini, M. Bertelli

The aim of this study was to assess the association between the TNFR1 rs2234649 polymorphism and ankylosing spondylitis susceptibility in a Russian Caucasian population. A total of 41 ankylosing spondylitis patients and 43 healthy controls, matched according to age and sex, were enrolled, and polymerase chain reac.. Read More»

Genet. Mol. Res. 16(1):

gmr16019581

DOI:

10.4238/gmr16019581

Evaluation of angiotensin-converting enzyme and adenosine deaminase polymorphisms in patients with type 2 diabetes mellitus

Authors: A.C.B. Domingos

Genet. Mol. Res. 9(2):

vol9-2ta030

DOI:

10.4238/vol9-2ta030

Relationship between glutathione S-transferase P1 polymorphisms and chronic obstructive pulmonary disease in a Tunisian population

Authors: R. Lakhdar, S. Denden, J. Knani, N. Leban, H. Daimi, M. Hassine, G. Lefranc, J. Ben Chibani and A. Haj Khelil

Chronic obstructive pulmonary disease (COPD) is a multifactorial disease with possible genetic predisposition and involvement of various environmental factors. Several candidate genes have been reported as potentially associated with this lung disease. The glutathione S-transferase P1 gene (GSTP1) was proposed to be involved i.. Read More»

Genet. Mol. Res. 9(2):

vol9-2gmr770

DOI:

10.4238/vol9-2gmr770

Increased risk of breast cancer in individuals carrying the TNRC9 rs3803662 C>T polymorphism: a meta-analysis of case-control studies

Authors: Q. Wang, N.Y. Wang, X.M. Cao, X. Sun, D. Shen, M. Yuan and J.F. Chen

Currently, the relationship between the trinucleotide repeat containing 9 (TNRC9) rs3803662 C>T polymorphism and risk of breast cancer (BC) is uncertain. Here, we attempted to obtain a more accurate assessment of this association by conducting a meta-analysis of all eligible case-control investigations, comprising 44,820 cases and 58,316 controls. A co.. Read More»

Genet. Mol. Res. 15(3):

gmr.15038218

DOI:

10.4238/gmr.15038218

Analysis of Fcgrt gene polymorphism in indigenous Chinese sheep and its association with colostrum IgG concentration

Authors: Z.H. Tian, F. Shi, F.G. Zhong, D.P. Bai and X.Y. Zhang

The neonatal Fc receptor (FcRn) plays an important role in regulating IgG homeostasis in the body and passive protection to the offspring. Changes in FcRn expression levels caused by genetic polymorphisms of Fcgrt, which encodes FcRn, may lead to inter-individual differences in colostrum IgG levels in sheep. In this study, we sequenced the FcRn partial he.. Read More»

Genet. Mol. Res. 14(1):

http://dx.doi.org/2015.March.30.4

DOI:

http://dx.doi.org/10.4238/2015.March.30.4

Gly71Arg UGT1A1 polymorphism is associated with breast cancer susceptibility in Han Chinese women

Authors: J. Shi, L.H. Li, X.Y. Duan, Q. Liu, L.L. Sun and Y.T. Tian

Breast cancer is among the most common causes of cancer-related death in women worldwide. Previous studies have demonstrated an association between prolonged estrogen exposure and increased risk of breast cancer. Uridine 5'-diphospho-glucuronosyltransferase 1-1 (UGT1A1) plays a significant role in the detoxification of estrogens. Two major genetic polymor.. Read More»

Genet. Mol. Res. 15(3):

gmr.15038332

DOI:

10.4238/gmr.15038332

HLA-G genetic variants and hepatocellular carcinoma: a meta-analysis

Authors: A.V.C. Coelho, R.R. Moura, S. Crovella and F. Celsi

Human leukocyte antigen (HLA)-G is a key tolerogenic molecule mainly expressed in the placenta and is crucial for implantation of the embryo and immunological tolerance of the fetus during pregnancy. However, under pathological conditions, such as cancer or viral infections, HLA-G can be expressed in other tissues. The gene coding for HLA-G (HLA-G, chromo.. Read More»

Genet. Mol. Res. 15(3):

gmr.15038263

DOI:

10.4238/gmr.15038263

Association between polymorphism of �²3-adrenoceptor gene and overactive bladder: a meta-analysis

Authors: H.C. Qu, W. Zhang, Y.L. Liu and P. Wang

Genetic variations in the human β3-adrenoceptor (β3-AR) gene are known to be involved in insufficient relaxation of the bladder muscle during urine storage. The Trp64Arg polymorphism in the β3-AR gene has been found to be an important regulator of the development of overactive bladder (OAB). However, the association between this polymorphis.. Read More»

Genet. Mol. Res. 14(1):

http://dx.doi.org/2015.March.30.7

DOI:

http://dx.doi.org/10.4238/2015.March.30.7