Genetic Polymorphism
Role of MTHFR C677T and MTR A2756G polymorphisms in thyroid and breast cancer development
Authors: T. Zara-Lopes, A.P.A. Gimenez-Martins, C.H.V. Nascimento-Filho, M.M.U. Castanhole-Nunes, A.L.S. Galbiatti-Dias, J.A. Padovani-J�ºnior, J.V. Maniglia, J.L.E. Francisco, E.C. Pavarino and E.M. Goloni-Bertollo
Folate metabolism is essential for DNA synthesis and repair. Alterations in genes that participate in folate metabolism can be associated with several types of malignant neoplasms, including thyroid and breast cancer. In the present case-control study, we examined the association between methylenetetrahydrofolate reductase (MT.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028222
- DOI:
- 10.4238/gmr.15028222
Association between the MTHFR C677T gene polymorphism and essential hypertension in South West Cameroon
Authors: S.M. Ghogomu, N.E. Ngolle, R.N. Mouliom and B.F. Asa
The association of the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and essential hypertension has been reported but with controversial results in diverse populations in Asia and Europe, thereby suggesting a dependency on ethnicity. The aim of this study was to investigate the association between the MTHFR C677T polymorphism and ess.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017462
- DOI:
- 10.4238/gmr.15017462
Effect of two single nucleotide polymorphisms on milk yield and composition
Authors: J.C. Rinc�³n, A. L�³pez-Herrera and J.J. Echeverri
The bovine prolactin (PRL) and bovine growth hormone (bGH) genes exhibit several polymorphisms. Some of them can be detected by molecular techniques using restriction endonucleases, such as RsaI for the PRL gene and MspI for the bGH gene. We examined the relationship between the PRL-RsaI and bGH-MspI polymorphisms and some economically important character.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.15
- DOI:
- 10.4238/2013.April.2.15
Vascular endothelial growth factor +405G/C and -2578C/A polymorphisms and breast cancer risk: a meta-analysis
Authors: Y. Zhang, Y.F. Yu, J.Z. Wang and H. Jia
This study aimed to analyze the association between the 405G/C and -2578C/A polymorphisms of the vascular endothelial growth factor (VEGF) gene and breast cancer risk by meta-analysis. A systematic computerized search of PubMed, Google Scholar, and Web of Science databases was performed to identify relevant publications. After rigorous searching and scree.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.14
- DOI:
- 10.4238/2015.August.3.14
Independent and joint effects of the IL-6 and IL-10 gene polymorphisms in pulmonary tuberculosis among the Chinese Han population
Authors: F.M. Feng, X.X. Liu, Y.H. Sun, P. Zhang, S.F. Sun, B. Zhang, X.T. Wang and L.J. Lu
We investigated the association between interleukin (IL)-6 and IL-10 gene polymorphisms and the susceptibility to pulmonary tuberculosis (PTB). DNA samples were obtained from 191 Han Chinese patients with PTB and 191 healthy control subjects. IL-6 (-572, -174, -597) and IL-10 (-1082, -819) polymorphisms were analyzed using pol.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.14
- DOI:
- 10.4238/2014.September.26.14
Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in a population from northeastern Brazil
Authors: C.M.A.R. Barros, A.P. Araujo-Neto, T.R. Lopes, M.A.L. Barros, F.J.N. Motta, R. Canalle, L.C.C. Nunes, J.A. Rey, R.R. Burbano, M.A. Lima-Barros, F.K.N. Yoshioka and G.R. Pinto
Approximately 200 million people suffer from type 2 diabetes (T2D) worldwide, and the rapid increase in the prevalence of this disease is likely a result of multiple environmental factors, such as increased food intake and decreased physical activity in genetically predisposed individuals. Different population studies have dem.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.1
- DOI:
- 10.4238/2014.September.29.1
Frequency of glutathione-S-transferase null-M1 and null-T1 genotypes among the Turabah population in Saudi Arabia
Authors: A.A. Mansour, O.M. Saleh, T. Askar, A.M. Salim and A. Mergani
Glutathione-S-transferases (GST) are key phase II detoxifying enzymes that play critical roles in protection against products of oxidative stress and against electrophiles. Glutathione S-transferase mu (GST-M1) and theta (GST-T1) are isoforms of glutathione transferase enzymes that participate in the metabolism of a wide range of chemicals. Deletion varia.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.13
- DOI:
- 10.4238/2015.December.14.13
HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk
Authors: S. Yan, Y.Z. Li, X.W. Zhu, C.L. Liu, P. Wang and Y.L. Liu
Genetic variations in the caspase genes CASP-3 and CASP-7 are known to be involved in apoptosis, cytokine maturation, cell growth and differentiation. Polymorphisms of CASP-3 and CASP-7 genes have been increasingly recognized as important regulators in the development of cancer. However, whether there is a specific association is still controversial. Ther.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.13.10
- DOI:
- 10.4238/2013.May.13.10
MCP-1 gene polymorphisms in North Chinese patients with pulmonary tuberculosis
Authors: G.L. Shi,L. Yang,Y. Sun,Y.J. Yin and C.X. Song
Pulmonary tuberculosis (PTB) remains one of the most important infectious diseases worldwide. Several studies have suggested that genetic factors may affect the susceptibility to PTB, but the specific genes involved have not been fully characterized. The gene for monocyte chemoattractant protein 1 (MCP-1) has been linked to an increased risk of tuberculos.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.18
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.18
Isolation and characterization of polymorphic microsatellite markers for blue fox (Alopex lagopus)
Authors: Y.M. Li, P.C. Guo, J.Y. Lu, C.Y. Bai, Z.H. Zhao and S.Q. Yan
The blue fox, belonging to the family Canidae, is a coat color variant of the native arctic fox (Alopex lagopus). To date, microsatellite loci in blue fox are typically amplified using canine simple sequence repeat primers. In the present study, we constructed an (AC)n enrichment library, and isolated and identified 17 polymor.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027990
- DOI:
- 10.4238/gmr.15027990