Genetic Polymorphism
Study of the relationship between IL-10 polymorphism and serum lipoprotein levels in Han Chinese individuals
Authors: W.Q. Yang
Previous studies have shown that cytokines can affect serum lipoprotein concentrations. The aim of this study was to examine the association between IL-10 gene polymorphisms and serum lipoprotein levels of Han Chinese individuals. A total of 359 Han Chinese people were enrolled in this investigation. IL-10 -592, -819, and -108.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028016
- DOI:
- 10.4238/gmr.15028016
Influence of GSTM1 and GSTT1 polymorphisms on the survival rate of patients with malignant glioma under perillyl alcohol-based therapy
Authors: M.M. Silva, C.O. Da Fonseca, R. Moura-Neto, J.F. Carvalho, T. Quirico-Santos and M.G. Carvalho
GSTM1 (glutathione S-transferase mu 1) and GSTT1 (glutathione S-transferase theta 1) are critical enzymes for detoxification of endogenous and environmental carcinogens. Constitutive GST gene polymorphisms may be associated with increased risk for cancer development. We made an explorative study of a Brazilian population with malignant glioma to determine.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.14.2
- DOI:
- 10.4238/2013.May.14.2
Association between IL-1RN gene polymorphisms and susceptibility to ankylosing spondylitis: a large Human Genome Epidemiology review and meta-analysis
Authors: G.X. Jin, J.Z. Duan, W.L. Guo, L. Li, S.Q. Cui and H. Wang
We made a Human Genome Epidemiology review and meta-analysis to examine a possible association between interleukin-1 receptor antagonist (IL-1RN) polymorphisms and susceptibility to ankylosing spondylitis (AS). Studies of IL-1RN polymorphisms and susceptibility to AS were found by searching the Pubmed, Cochrane library, Embase, Web of Science, Springerlin.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.21.3
- DOI:
- 10.4238/2013.May.21.3
Investigation of polymorphisms in exon7 of the NSUN7 gene among Chinese Han men with asthenospermia
Authors: H.Y. Ren, R. Zhong, X.P. Ding, Z.Y. Chen and Y.L. Jing
Previous studies have shown that genetic polymorphisms in exon7 of the NSUN7 gene can be used as an infertility marker in Iranian men with asthenospermia. However, there have been no equivalent studies in China. In the present study, we investigated the possible association between the genetic polymorphisms in exon7 of NSUN7 and asthenospermia in a Chines.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.6
- DOI:
- 10.4238/2015.August.10.6
Genetic polymorphisms of loci D18S53, D18S59, and D18S488 in fetuses from a Chinese Tianjin Han population
Authors: X.Z. Li, J. Liu, Y.F. Shi, D. Ju, Y. Zhang and T.F. Yue
We investigated the genetic polymorphisms of three short tandem repeat (STR) loci, D18S53, D18S59, and D18S488, on chromosome 18 in fetuses from a Chinese Tianjin Han population. Sixty-four villus samples and 374 amniotic fluid samples were collected from fetuses. Quantitative fluorescence polymerase chain reaction was perform.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027820
- DOI:
- 10.4238/gmr.15027820
A case-control study of CYP2E1 (PstI) and CYP1A1 (MspI) polymorphisms in colorectal cancer
Authors: M.A. Proen�§a, G.M.M. Fernandes, A. Russo, R.B. Lelis, J.G. Netinho, G.S. Cunrath, A.E. Silva, E.M. Goloni-Bertollo and E.C. Pavarino
Polymorphisms in genes encoding P450 cytochrome enzymes may increase the risk of sporadic colorectal cancer (SCRC). Here we investigated the association between SCRC and CYP2E1 (PstI) and CYP1A1 (MspI) polymorphisms in a case-control study. Moreover, we sought to determine any possible associations between this disease and the sociodemographic factors. We.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.10
- DOI:
- 10.4238/2015.December.22.10
Genetic polymorphism at spinocerebellar ataxia 1 and 2 loci in Brazil
Authors: Stenio F.P. Duarte, Raquel S. Gestinari, M�¡rio Campos-Jr, M�¡rcia M.G. Pimentel, Marcelo A. Costa Lima
Dynamic mutation involves the expansion of a tandem arrayed DNA sequence that is polymorphic in the population. This mechanism is associated with neurological/neuromuscular disorders and the pathology depends on the extension of the repeated tract, with a specific threshold for each disease. We made a PCR-based characterizatio.. Read More»
- Genet. Mol. Res. 2(4):