Genetics
Tetraploidization in Wilms tumor in an infant
Authors: E.T. Valera*, M.S. Brassesco*, C.A. Scrideli and L.G. Tone
Genetic instability is frequent in human cancer. Unscheduled tetraploidization can trigger cell transformation and tumorigenesis. We made a cytogenetic analysis by Giemsa-trypsin banding of a stage I, biphasic Wilms tumor diagnosed in a 10-month-old male. An evident karyotypic heterogeneity was found. Four different subclones .. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr880
- DOI:
- 10.4238/vol9-3gmr880
Development and characterization of 32 microsatellite loci in the giant grouper Epinephelus lanceolatus (Serranidae)
Authors: S. Yang, L. Wang, Y. Zhang, X.C. Liu, H.R. Lin and Z.N. Meng
An economically important marine fish species, the giant grouper Epinephelus lanceolatus (Serranidae) is widely cultured in Taiwan and costal areas of China. We isolated and characterized 32 polymorphic microsatellite loci from a CA-enriched genomic library of giant grouper. The number of alleles per locus ranged from 3 to 7, .. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.12.3
- DOI:
- 10.4238/2011.December.12.3
Worldwide diversity of the Y-chromosome tetra-local microsatellite DYS464
Authors: F.S.G. Kehdy and S.D.J. Pena
Of all DNA markers on the human Y-chromosome, the tetra-local Y-linked microsatellite DYS464 is the most polymorphic. We genotyped DYS464 in 677 male samples collected worldwide, maintained in the HGDP-CEPH Human Genome Diversity Cell Line Panel. Fourteen different alleles were found, with allele lengths varying from 9 to 23 r.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr968
- DOI:
- 10.4238/vol9-3gmr968
Sulcus vocalis: evidence for autosomal dominant inheritance
Authors: R.H.G. Martins, T.M. Gon�§alves, D.S. Neves, T.A. Fracalossi, E.L.M. Tavares and D. Moretti-Ferreira
We found evidence of autosomal dominant hereditary transmission of sulcus vocalis. Four dysphonic patients from three generations of the same family were submitted to videolaryngoscopic examination (three patients) and to direct laryngoscopy (one patient) to diagnose the hoarseness. Sulcus vocalis was diagnosed in all four pat.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.19.5
- DOI:
- 10.4238/2011.December.19.5
Isolation and characterization of microsatellite loci in the purpleback flying squid (Sthenoteuthis oualaniensis)
Authors: L. Lin, P. Li, Z.Z. Chen, Y.Y. Xiao, S.N. Xu, Y. Liu and C.H. Li
The purpleback flying squid (Sthenoteuthis oualaniensis) is a pelagic squid with tremendous potential for commercial exploitation. We isolated and characterized 21 polymorphic microsatellite loci for S. oualaniensis using a (GT)13-enriched genomic library. The number of alleles per locus varied from 6 to 32. The observed and expected heterozygosities rang.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.13.7
- DOI:
- 10.4238/2015.July.13.7
Genetic variability in maned wolf based on heterologous short-tandem repeat markers from domestic dog
Authors: Salim DC, Akimoto AA, Carvalho CB, Oliveira SF, Grisolia CK, Moreira JR and Klautau-Guimaraes MN
The maned wolf (Chrysocyon brachyurus) is the largest South American canid. Habitat loss and fragmentation, due to agricultural expansion and predatory hunting, are the main threats to this species. It is included in the official list of threatened wildlife species in Brazil, and is also protected by IUCN and CITES. Highly var.. Read More»
- Genet. Mol. Res. 6(2):
Remarkably low genetic variation but high population differentiation in the climbing perch, Anabas testudineus (Anabantidae), based on the mtDNA control region
Authors: A.F.J. Jamsari, Z.A. Muchlisin, M. Musri and M.N. Siti Azizah
Anabas testudineus (Anabantidae) is an important food fish in Southeast Asia. We analyzed the mitochondrial DNA control region sequence data to evaluate the genetic variability and population structure of this species. Sixty specimens were collected from four populations in Sumatra and two populations in Peninsular Malaysia. W.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr933
- DOI:
- 10.4238/vol9-3gmr933
Performance of human immunostimulating agents in the improvement of fish cytogenetic preparations
Authors: W.F. Molina, D.E.O. Alves, W.C. Ara�ºjo, P.A. Martinez, M.F.M. Silva and G.W.W.F. Costa
Inoculation with bacterial or fungal antigens that stimulate cell proliferation has been widely used to obtain metaphases for cytogenetic studies of fish. We evaluated the potential of new pharmaceutical compounds as mitogenic agents in fish, testing the efficacy of Aminovac® (mixed antigens and epsilon-acetamidocaproic ac.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr840
- DOI:
- 10.4238/vol9-3gmr840
Localization and expression of histone H2A variants during mouse oogenesis and preimplantation embryo development
Authors: B.J. Wu, F.L. Dong, X.S. Ma, X.G. Wang, F. Lin and H.L. Liu
Epigenetic modifications of the genome, such as histone H2A variants, ensure appropriate gene activation or silencing during oogenesis and preimplantation embryo development. We examined global localization and expression of the histone H2A variants, including H2A.Bbd, H2A.Z and H2A.X, during mouse oogenesis and preimplantatio.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.7.8
- DOI:
- 10.4238/2014.August.7.8
Temporal genetic differentiation in cultured and natural beds of the brown mussel Perna perna (Mytilidae)
Authors: Appio KT and Weber LI
Perna perna is the most important cultivated mussel of Santa Catarina, Brazil, sustaining an important economic input for many local families. Natural stocks of P. perna are depleted by the extraction of adults and seeds for consumption and culture. The aim of the present study was to use the microsatellite locus pms-2 to stud.. Read More»
- Genet. Mol. Res. 6(1):