Genomics
Integrative omics of ovarian cancer
Authors: Yanisa Rattanapan and Takol Chareonsirisuthigul
Omics such as genomics, transcriptomics, proteomics, and metabolomics are gathering the study of entire characterization and molecular biology processes of organisms. The advancement in studying omics has become useful and widely applied to many human diseases. For ovarian cancer, pathogenic mechanisms at molecular levels resulting in the development of c.. Read More»
- Genet. Mol. Res. 18(4):
Expression of lipid metabolism and myosin heavy chain genes in pigs is affected by genotype and dietary lysine
Authors: RC Veloso, PS Lopes, MS Duarte, FF Silva, A Saraiva, ML Chizzotti, W Silva and SEF Guimar�£es
Expression of lipid metabolism and myosin heavy chain genes was evaluated in skeletal muscle of pig’s genotypes submitted to different dietary digestible lysine contents. Fifty-two barrows and fifty gilts from three genotypes (G: Piau, Duroc and Pietrain crossbreds) were assigned to three dietary digestible lysine conten.. Read More»
- Genet. Mol. Res. 17(2):
- gmr16039904
- DOI:
- 10.4238/gmr16039904
Effect of CYP3A5 gene polymorphisms on tacrolimus concentration/dosage ratio in adult liver transplant patients
Authors: L. Wang, L.H. Liu, W.H. Tong, M.X. Wang and S.C. Lu
We examined the influence of the cytochrome P450 3A5 (CYP3A5) genes in both donors and recipients on the concentration-dosage ratio (C/D) of tacrolimus in Chinese liver transplant patients. Fifty-one adult liver transplant patients who received tacrolimus were included in this study. The CYP3A5 polymorphism i.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.25.3
- DOI:
- 10.4238/2015.November.25.3
Genetic polymorphisms in very important pharmacogenomic (VIP) variants in the Tibetan population
Authors: T.B. Jin, X.J. Xun, X.G. Shi, D.Y. Yuan, T. Feng, T.T. Geng and L.L. Kang
Genetic polymorphisms of very important pharmacogenomic (VIP) variants are important for personalized medicine. However, these have not been extensively studied in the Tibetan population. In this study, 82 VIP variants were detected in the Tibetan and Han (HAN) populations from northwestern China. Subsequently, we compared the.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.16.17
- DOI:
- 10.4238/2015.October.16.17
Bioinformatics: an overview and its applications
Authors: W.J.S. Diniz and F. Canduri
Technological advancements in recent years have promoted a marked progress in understanding the genetic basis of phenotypes. In line with these advances, genomics has changed the paradigm of biological questions in full genome-wide scale (genome-wide), revealing an explosion of data and opening up many possibilities. On the ot.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019645
- DOI:
- 10.4238/gmr16019645
Prevalence of thymidylate synthase gene 5'-untranslated region variants in an Argentinean sample
Authors: C. VÃ?¡zquez, M. Orlova, P. Scibona, H. DÃ?Âaz Arce, M.G. Pallotta and W.H. Belloso
Thymidylate synthase (TYMS) is a key enzyme in nucleotide synthesis and therefore, an important target of many chemotherapeutic agents. Expression of TYMS mRNA is thought to be modulated by a 28-bp tandem repeat polymorphism within its 5'-untranslated region, raising the question of this variant’s utility in predicting t.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019367
- DOI:
- 10.4238/gmr16019367
Application of genomics and proteomics in drug target discovery
Authors: H.M. Zhang, Z.R. Nan, G.Q. Hui, X.H. Liu and Y. Sun
Gene medicine is making breakthroughs in health questions that have baffled humanity for centuries. To understand and utilize gene medicine, it is necessary to realize its action against targets at the molecular level. Currently, many methods can be used to discover drug targets; among these, genomic and proteomic methods are .. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.10.11
- DOI:
- 10.4238/2014.January.10.11
Application of functional genomic information to develop efficient EST-SSRs for the chicken (Gallus gallus)
Authors: M.R. Bakhtiarizadeh, B. Arefnejad, E. Ebrahimie and M. Ebrahimi
Many years of domestication and breeding have given rise to the wide range of chicken breeds that exist today; however, an increasing number of local chicken breeds are under threat of extinction. A comprehensive characterization of chicken markers (especially type I markers) is needed to monitor and conserve genetic diversity.. Read More»
- Genet. Mol. Res. 11(2):
- dx.doi.org/2012.May.21.12
- DOI:
- dx.doi.org/10.4238/2012.May.21.12
Comparative genomics of grasses tolerant to aluminum
Authors: Jardim SN
The family Poaceae includes over 10,000 species, among which are the most economically important cereals: maize, sorghum, rice, wheat, rye, barley, and oat. These cereals are very important components of human and animal food. Although divergence of the members of this family occurred about 40 million years ago, comparative ge.. Read More»
- Genet. Mol. Res. 6(4):
High yield of functional metagenomic library from mangroves constructed in fosmid vector
Authors: A.C.S. Gon�§alves, A.C.F. dos Santos, T.F. dos Santos, T.B.A. Pessoa, J.C.T. Dias and R.P. Rezende
In the present study, metagenomic technique and fosmid vectors were used to construct a library of clones for exploring the biotechnological potential of mangrove soils by isolation of functional genes encoding hydrolytic enzymes. The library was built with genomic DNA from the soil samples of mangrove sediments and the functi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.2.17
- DOI:
- 10.4238/2015.October.2.17