Genomics
Public sphere and the sustainability of the bioinformatics promise
Authors: Marcelo Leite
The literature about genomics and bioinformatics achievements in high-impact journals such as Nature and Science has raised disproportionate expectations amongst the general public about fast and revolutionary drugs and breakthroughs in biomedicine. However, the yield obtained by database mining activities has been modest, as .. Read More»
- Genet. Mol. Res. 3(4):
Bioinformatics: perspectives for the future
Authors: Luciano da Fontoura Costa
I give here a very personal perspective of Bioinformatics and its future, starting by discussing the origin of the term (and area) of bioinformatics and proceeding by trying to foresee the development of related issues, including pattern recognition/data mining, the need to reintegrate biology, the potential of complex network.. Read More»
- Genet. Mol. Res. 3(4):
Update of microbial genome programs for bacteria and archaea
Authors: Patricia Borges Santos Celestino, Lydston Rodrigues de Carvalho,Leandro Martins de Freitas, Fernanda Alves Dorella, Natalia Flor�ªncio Martins, Luiz Gustavo Carvalho Pacheco, Anderson Miyoshi and Vasco Azevedo
Since the Haemophilus influenzae genome sequence was completed in 1995, 172 other prokaryotic genomes have been completely sequenced, while 508 projects are underway. Besides pathogens, organisms important in several other fields, such as biotechnology and bioremediation, have also been sequenced. Institutions choose the organ.. Read More»
- Genet. Mol. Res. 3(3):
Integrating genomics into Eucalyptus breeding
Authors: Dario Grattapaglia
The advent of high throughput genomic technologies has opened new perspectives in the speed, scale and detail with which one can investigate genes, genomes and complex traits in Eucalyptus species. A genomic approach to a more detailed understanding of important metabolic and physiological processes, which affect tree growth a.. Read More»
- Genet. Mol. Res. 3(3):
New genomic resources for the honey bee(Apis mellifera L.): development of a deep-coverage BAC library and a preliminary STC database
Authors: J.P. Tomkins, M. Luo, G.C. Fang1, D. Main1, J.L. Goicoechea,M. Atkins, D.A. Frisch, R.E. Page, E. Guzm�¡n-Novoa5, Y. Yu,G. Hunt6 and R.A. Wing
We have constructed a bacterial artificial chromosome (BAC) library for a European honey bee strain using the cloning enzyme HindIII in order to develop resources for structural genomics research. The library contains 36,864 clones (ninety-six 384-well plates). A random sampling of 247 clones indicated an average insert size o.. Read More»
- Genet. Mol. Res. 1(4):