Genotoxicity
Modulatory effect of Palicourea coriacea (Rubiaceae) against damage induced by doxorubicin in somatic cells of Drosophila melanogaster
Authors: D.C.S. Passos, H.D. Ferreira, I.L.F.B. Vieira, W.B. Nunes, L.P. Fel?cio, E.M. Silva, C.R. Vale, S.R. Duarte, E.S. Silva and S. Carvalho
Palicourea coriacea, popularly known as “douradinha”, is a medicinal plant from the Brazilian Cerrado region used in folk medicine to treat kidney and urethral stones and kidney inflammation. We evaluated the cytotoxic, genotoxic, and possible antigenotoxic activities of an aqueous extract of P. coriacea on somatic.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr801
- DOI:
- 10.4238/vol9-2gmr801
Modulatory effect of Byrsonima verbascifolia (Malpighiaceae) against damage induced by doxorubicin in somatic cells of Drosophila melanogaster
Authors: D.M. Mendanha, H.D. Ferreira, L.P. Fel?cio, E.M. Silva, D.G. Pereira, W.B. Nunes and S. Carvalho
Byrsonima verbascifolia, popularly known in Brazil as murici, is a medicinal plant widely used in the treatment of bacterial and viral infections, Chagas’s disease, diarrhea, bronchitis, cough and fever, as well as for protection of the intestinal mucosa. Since chemotherapy and radiotherapy, broadly employed in the treat.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr678
- DOI:
- 10.4238/vol9-1gmr678
Effect of polychlorinated biphenyls on oxidation stress in the liver of juvenile GIFT, Oreochromis niloticus
Authors: Y. Zheng, L.P. Qiu, S.L. Meng, L.M. Fan, C. Song, D.D. Li, C. Zhang and J.Z. Chen
The present study clearly showed that chronic exposure to polychlorinated biphenyls (PCBs) at environmentally relevant concentrations can damage juvenile tilapia livers by modulating antioxidant enzyme activities and gene transcription, which affects toxic bioaccumulation and histological congestion. The results suggest that P.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038613
- DOI:
- 10.4238/gmr.15038613
Genotoxicity in oral epithelial cells in children caused by nickel in metal crowns
Authors: J. Mor?¡n-Mart?nez, K.D. Monreal-de Luna, N.D. Betancourt-Mart?nez, P. Carranza-Rosales, J.G. Contreras-Mart?nez, M.C. L?³pez-Meza and O. Rodr?guez-Villarreal
The micronucleus (MN) assay evaluates the effects of low doses of genotoxic carcinogens and can detect structural lesions that survive mitotic cycles. The objective of this study was to determine both the genotoxicity of nickel (Ni) in buccal epithelial cells and the urinary excretion of Ni in children with metal crowns. This was a prospective longitudina.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.29.1
- DOI:
- 10.4238/2013.August.29.1
Antigenotoxic and anticytotoxic activity of Duguetia furfuracea in bacteria and mice
Authors: C.R. Silva, P.M. Vieira and L. Chen-Chen
Duguetia furfuracea (St. Hil.) Benth & Hook f. (1862), popularly known as â????sofre-do-rim-quem-querâ??? and â????araticum-secoâ???, is a shrub of the Annonaceae family that grows in several regions of Brazil. Infusions of its leaves and twigs are used in folk medicine to treat rheumatism and renal colic, whe.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.2
- DOI:
- 10.4238/2013.September.19.2
Antigenotoxic, and anticytotoxic activities of an ethanolic extract of Lafoensia pacari (Lythraceae) stem bark in bacteria and mice
Authors: D.C.S. Lima, C.R. Silva, B.L. Sampaio, J.R. de Paula and L. Chen-Chen
Lafoensia pacari (Lythraceae), popularly known in Brazil as “pacari”, is a small tree native to the Cerrado that is used in folk medicine to treat cancer and as an anti-inflammatory and cicatrizing agent. We evaluated the genotoxic, cytotoxic, antigenotoxic, and anticytotoxic activities of an ethanol extract of L. pacari stem bark (EESB) using.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.7
- DOI:
- 10.4238/2013.September.23.7
Evaluation of genotoxic and cytotoxic effects of antileishmanial extract from Julocroton triqueter (Euphorbiaceae)
Authors: V.R. Moreira, A.C.S. Dias, A.R.P. Martins, M.I.S. Lima, I.C.P.B. Serra, M.N.S. Ribeiro, F.R.F. Nascimento and S.R.F. Pereira
Julocroton triqueter extracts have antileishmanial activity; however, the effect on genetic stability has not been studied. We evaluated genotoxic and cell death induction potential (in vitro and in vivo) of J. triqueter var. triqueter hydroalcoholic extracts, as well as their antigenotoxic potential in vivo. The in vitro genotoxic studies were performed .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.10.8
- DOI:
- 10.4238/2013.April.10.8
Evaluation of the genotoxic activity of dicamba and atrazine herbicides in several Mexican and South American varieties of sweetcorn (Zea mays L.)
Authors: M.S. Reynoso, C.M. Alvarez, L. De la Cruz, M.D. Escoto and J.J.G. S?¡nchez
Corn is a major crop and various herbicides are used to maximize its production, which include a dicamba-atrazine mixture. This has great advantages, but can also induce DNA damage. Genotoxic activity was assessed by comet assay following application of two concentrations of dicamba-atrazine: 1000-2000 and 2000-4000 ppm. Apical meristem leaf nuclei from 1.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.5
- DOI:
- 10.4238/2015.December.11.5
Modulatory effects of Duguetia furfuracea (A. St. Hil) Benth. and Hook. f. in Drosophila melanogaster somatic and germinative cells
Authors: L.S. Coelho, L.P. Felicio, C.T. Miranda, E.M. da Silva, C.R. Vale, D.C.S. Lima, S.R. Duarte, H.D. Ferreira, L. Chen Chen and S. Carvalho
Mutagenic and antimutagenic activities of the medicinal plant Duguetia furfuracea were assessed using SMART/wing and ring-X-loss tests. For the ring-X-loss test, 2- to 3-day-old Drosophila melanogaster ring-X-lineage males and virgin ywsn3 females received D. furfuracea infusion at doses of 0.085, 0.042, or 0.014 g/mL for 24 h.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr983
- DOI:
- 10.4238/vol10-1gmr983
Mutagenic potential and modulatory effects of the medicinal plant Luehea divaricata (Malvaceae) in somatic cells of Drosophila melanogaster: SMART/wing
Authors: L.P. Fel?cio, E.M. Silva, V. Ribeiro, C.T. Miranda, I.L.B.F. Vieira, D.C.S. Passos, A.K.S. Ferreira, C.R. Vale, D.C.S. Lima, S. Carvalho1 and W.B. Nunes
Luehea divaricata is a native plant of the Brazilian Cerrado, known as “açoita-cavalo”. It is used as a popular herbal medicine in the treatment of dysentery, bleeding, arthritis, tumors, ulcers, and gangrenous wounds. Considering that herbal medicines sometimes provoke tumors and/or may prevent mutational e.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr982
- DOI:
- 10.4238/vol10-1gmr982