Glioblastoma
Glioblastoma in a 20-year-old female patient after Chikungunya infection
Authors: L.O. Mour�?£o, L. Delmonico, A.S. Moreira, K.R. Bulsara, T. Da Luz, R.T. Silvestre, A.C.B. Koifman, L.C. Guida, G.N. Soares, M.G.C. Carvalho, M.H. Ornellas and G. Alves
We describe the case of a 20-year-old female patient who died 4 months after the diagnosis of a glioblastoma (GBM). The tumor emerged nearly a month after a Chikungunya (CHIKV) infection and displayed positivity to Citomegalovirus (CMV) DNA. The immunohistochemical studies revealed GFAP positivity in rare cells, IDH-1 positive, vimentin positive, ATRX pos.. Read More»
- Genet. Mol. Res. 18(1):
GSTP1 Ile105Val polymorphism in astrocytomas and glioblastomas
Authors: A.C. Cust�?³dio, L.O. Almeida, G.R. Pinto, M.J. Santos, J.R.W. Almeida, C.A. Clara, J.A. Rey and C. Casartelli
Glutathione S-transferases (GSTs) constitute a superfamily of ubiquitous multifunctional enzymes that are involved in the cellular detoxification of a large number of endogenous and exogenous chemical agents that have electrophilic functional groups. People who have deficiencies in this family of genes are at increased risk of.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr971
- DOI:
- 10.4238/vol9-4gmr971
Targeting effect of microRNA on CD133 and its impact analysis on proliferation and invasion of glioma cells
Authors: C. Zhao, Z.G. Ma, S.L. Mou, Y.X. Yang, Y.H. Zhang, W.C. Yao
MiR-200b, a member of the microRNA-200 family, has been identified to be capable of suppressing glioma cell growth through targeting CREB1 or CD133. However, whether miR-200b affects the biological behavior (proliferation, invasion, and migration) of glioma cells is poorly understood. The aim of this study was to evaluate the .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019281
- DOI:
- 10.4238/gmr16019281
Variation in DNA repair gene XRCC3 affects susceptibility to astrocytomas and glioblastomas
Authors: A.C. Cust�?³dio, L.O. Almeida, G.R. Pinto, M.J. Santos, J.R.W. Almeida, C.A. Clara, J.A. Rey and C. Casartelli
The gene XRCC3 (X-ray cross complementing group 3) has the task of repairing damage that occurs when there is recombination between homologous chromosomes. Repair of recombination between homologous chromosomes plays an important role in maintaining genome integrity, although it is known that double-strand breaks are the main .. Read More»
- Genet. Mol. Res. 11(1):
- 2012.February.10.4
- DOI:
- 10.4238/2012.February.10.4
Analysis of the polymorphisms XRCC1Arg194Trp and XRCC1Arg399Gln in gliomas
Authors: A.C. Cust�?³dio, L.O. Almeida, G.R. Pinto, M.J. Santos, J.R.W. Almeida, C.A. Clara, J.A. Rey and C. Casartelli
XRCC genes (X-ray cross-complementing group) were discovered mainly for their roles in protecting mammalian cells against damage caused by ionizing radiation. Studies determined that these genes are important in the genetic stability of DNA. Although the loss of some of these genes does not necessarily confer high levels of se.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1125
- DOI:
- 10.4238/vol10-2gmr1125
Dysregulation of TFDP1 and of the cell cycle pathway in high-grade glioblastoma multiforme: a bioinformatic analysis
Authors: X. Lu, X.D. Lv, Y.H. Ren, W.D. Yang, Z.B. Li, L. Zhang and X.F. Bai
Despite extensive research, the prognosis of high-grade glioblastoma multiforme (GBM) has improved only slightly because of the limited response to standard treatments. Recent advances (discoveries of molecular biomarkers) provide new opportunities for the treatment of GBM. The aim of the present study was to identify diagnost.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027646
- DOI:
- 10.4238/gmr.15027646