Glucose
High levels of glucose promote the activation of hepatic stellate cells via the p38-mitogen-activated protein kinase signal pathway
Authors: L.K. Wu, Y.C. Liu, G. Ma, L.L. Shi and X.M. He
The relationship between the p38-mitogen-activated protein kinase (p38-MAPK) signal pathway and high glucose-induced hepatic stellate cell (HSC) activation was investigated in this study. Sixty human HSC samples were randomly selected and used in the control (cultured normally), high-glucose (cultured in the presence of high g.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038419
- DOI:
- 10.4238/gmr.15038419
Association between ACP1 genetic polymorphism and favism
Authors: V. Polzonetti, V. Passini and N. Lucarini
An association between favism (a hemolytic reaction to consumption of fava beans), glucose-6-phosphate dehydrogenase deficiency (G6PD-) and acid phosphatase locus 1 (ACP1) phenotypes has been reported; the frequency of carriers of the pa and pc ACP1 alleles was found to be significantly higher in G6PD- individuals showing favi.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1062
- DOI:
- 10.4238/vol10-2gmr1062
Zinc finger protein A20 overexpression inhibits monocyte homing and protects endothelial cells from injury induced by high glucose
Authors: C.L. Hou, W. Zhang, Y. Wei, J.H. Mi, L. Li, Z.H. Zhou, W. Zeng and D.J. Ying
Diabetes mellitus causes vascular lesions and may ultimately lead to atherosclerosis. One of the earliest steps in the development of atherosclerotic lesions is the adhesion of monocytes to endothelial cells of the vessel wall. It is currently unknown whether zinc finger protein A20 is able to protect endothelial cells from in.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1102
- DOI:
- 10.4238/vol10-2gmr1102
Protection from vascular endothelial dysfunction in acute glycemic load-induced primary hypertension by vitamin C and E
Authors: J.X. Xu, L. Su, L. Chen and J.X. Lin
This study aimed to investigate the influence of acute glycemic load on vascular endothelial function in patients with hypertension and to evaluate the protective effect of vitamins C and E during the acute glycemic phase. We randomly selected 39 hypertensive patients and 21 normal subjects and divided them into 3 groups: 75 g.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.5.9
- DOI:
- 10.4238/2014.September.5.9
Biological correlation between glucose transporters, Ki-67 and 2-deoxy-2-[18F]-fluoro-D-glucose uptake in diffuse large B-cell lymphoma and natural killer/T-cell lymphoma
Authors: Y.M. Liu, X.M. Zhai and Y.W. Wu
The purpose of this study was to investigate the association between cellular 2-deoxy-2-[18F]-fluoro-D-glucose (18F-FDG) uptake and the expression of several subtypes of glucose transporters (GLUT) and Ki-67 in diffuse large B-cell lymphoma (DLBCL) and natural killer (NK)/T-cell lymphoma (NKTCL). Cell lines were histologically.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027242
- DOI:
- 10.4238/gmr.15027242
Association of KCNJ11 with impaired glucose regulation in essential hypertension
Authors: Y. Wang, X.O. Zhou, Y. Zhang, P.J. Gao and D.L. Zhu
KCNJ11 is one of the candidate genes for type 2 diabetes, confirmed by genome wide association study, but there are little data on the relationship between KCNJ11 and impaired glucose regulation in essential hypertension patients. To identify the effect of E23K and I337V in the KCNJ11 gene on susceptibility to impaired glucose.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1127
- DOI:
- 10.4238/vol10-2gmr1127
Cloning and functional analysis of goat SWEET1
Authors: L.Q. Zhu, Z.K. Bao, W.W. Hu, J. Lin, Q. Yang and Q.H. Yu
SWEETs are a recently discovered class of sugar transporters that mediate glucose uptake in the intestine and mammary glands. Our objectives were to clone goat SWEET1 and conduct a functional analysis of its effect on glucose efflux in goat mammary gland epithelial cells. We cloned and sequenced the goat SWEET1 gene from goat mammary glands, then conducte.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.12
- DOI:
- 10.4238/2015.December.16.12
Effect of hypothalamic-pituitary-adrenal axis alterations on glucose and lipid metabolism in diabetic rats
Authors: M.W. Si, M.K. Yang and X.D. Fu
This study investigated the relationship between alterations in the hypothalamic-pituitary-adrenal (HPA) axis function and glucose and lipid metabolism in diabetic rats. To accomplish this a diabetes model was established by jointly administering a long-term high-fat diet plus Streptozotocin (STZ; 50 mg/kg ip). The rats were randomly divided into four gro.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.19
- DOI:
- 10.4238/2015.August.14.19
Cloning and characterization of ADP-glucose pyrophosphorylase small subunit gene in Cyperus esculentus (yellow nutsedge)
Authors: C. Cheng, J. Hu, Y. Zhi, J.J. Su, X.K. Zhang and B.Q. Huang
ADP-glucose pyrophosphorylase (ADPGlcPPase) controls the first committed step of starch synthesis by catalyzing the biosynthesis of ADP-glucose from glucose-phosphate and ATP. It is a tetrameric protein consisting of two small and two large subunits. The small subunits have a catalytic function, while the large subunits regulate the enzyme activity. Cyper.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.18
- DOI:
- 10.4238/2015.December.23.18