Growth
Correlation of VCAM-1 expression in serum, cord blood, and placental tissue with gestational hypertension associated with fetal growth restriction in women from Xingtai Hebei, China
Authors: H.G. Zhang, W. Guo, H.F. Gu, S.B. Chen, J.Q. Wang, Z.X. Qiao, H.S. Ma and S.X. Geng
The aim of this study was to investigate the expression of vascular adhesion molecule (VCAM)-1 in the maternal serum, cord blood, and placental tissue of pregnant women from Xingtai, Hebei, with gestational hypertension (GH) combined with fetal growth restriction (FGR). A total of 108 patients with GH combined with FGR (GH-FGR), 60 patients with GH alone .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038274
- DOI:
- 10.4238/gmr.15038274
TGF-�²1 polymorphisms and familial aggregation of liver cancer in Guangxi, China
Authors: P.Q. Wan, J.Z. Wu, L.Y. Huang, J.L. Wu, Y.H. Wei and Q.Y. Ning
The goal of present study was to investigate the relationship between polymorphisms of TGF-β1 and familial aggregation of liver cancer in Guangxi Zhuang, Han, and Yao populations. We conducted a population-based case-control family study of liver cancer in Guanxi, China. A total of 214 individuals from 37 case families were surveyed for polymorphisms.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.3
- DOI:
- 10.4238/2015.July.27.3
Transforming growth factor beta-1 expression in macrophages of human chronic periapical diseases
Authors: Z.-Z. Liang, J. Li, S.-G. Huang
The objective of this study was to observe the distribution of macrophages (MPs) expressing transforming growth factor beta-1 (TGF-β1) in tissue samples from patients with different human chronic periapical diseases. In this study, samples were collected from 75 volunteers, who were divided into three groups according to .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019329
- DOI:
- 10.4238/gmr16019329
Impact and significance of EGCG on Smad, ERK, and �²-catenin pathways in transdifferentiation of renal tubular epithelial cells
Authors: C.G. Zhao, P. Zhou and Y.B. Wu
We investigated the impact and signal transduction mechanisms of epigallocatechin-3-gallate (EGCG) on transdiffer-entiation of renal tubular epithelial cells. Rat renal tubular epithelial cells (NRK-52E) were randomly divided into a normal control group, transforming growth factor (TGF)-b1-induced group (10 ng/mL), and intervention groups with 200 mg/L EG.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.14
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.14
Effect of casein genes - beta-LGB, DGAT1, GH, and LHR - on milk production and milk composition traits in crossbred Holsteins
Authors: A. Molee, C. Poompramun and P. Mernkrathoke
The objectives of this study were to determine the effects of a single gene and composite genotype of the casein gene family, including the beta-lactoglobulin gene (beta-LGB), acyl-CoA: diacylglycerol acyltransferase 1 gene (DGAT1), growth hormone gene (GH), and luteinizing hormone receptor gene (LHR) on milk yield, milk composition, the percentage of fat.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.15
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.15
Three branches of phospholipase C signaling pathway promote hepatocyte growth in rat liver regeneration
Authors: G.G. Xu, Z. Geng, X.C. Zhou, Y.G. He, T.T. He, J.X. Mei,Y.J. Yang, Y.Q. Liu and C.S. Xu
In general, the phospholipase C (PLC) signaling pathway is involved in many physiological activities, including cell growth. However, little is known regarding how the PLC signaling pathway participates in regulating hepatocyte (HC) growth during liver regeneration (LR). To further explore the influence of the PLC signaling pathway on HCs at the cellular .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.29.3
- DOI:
- 10.4238/2015.May.29.3
Investigation of the role of VEGF gene polymorphisms in the risk of osteosarcoma
Authors: G. Zhang, R. Bai, T. Zhang, H. Zhang, S.Z. Wen and D.M. Jiang
We conducted a case-control study in a Chinese population, and assessed whether the VEGF -634G/C, +936C/T, and +1612G/A polymorphisms could affect the risk of osteosarcoma and its association with environmental factors. A total of 180 consecutive osteosarcoma patients and 360 controls were included in our study. The genotypes of VEGF -634G/C, +936C/T, and.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.16
- DOI:
- 10.4238/2015.July.27.16
Synergistic and threshold effects of GH1 and GHR promoter size variation on body growth and fat accrual in young Nelore (Bos indicus) bulls
Authors: M.A. Dani, M. von Cube, I.L. Freire, L. Suguisawa, C. Fischer, S.U. Dani
A synergistic effect in the somatotropic axis (GH1-GHR-IGF1) was observed in 736 young Nelore (Bos indicus) bulls under ad libitum grass feeding conditions on irrigated pasture in central Brazil. Stepwise substitution of shorter alleles of the promoter region of the growth hormone gene (GH1) and the P1 promoter of the GH1 rece.. Read More»
- Genet. Mol. Res. 11(2):
- http://dx.doi.org/2012.June.29.11
- DOI:
- http://dx.doi.org/10.4238/2012.June.29.11
Relevance of E-cadherin expression to EGFR-TKI molecular targeted therapy sensitivity/resistance and its clinical significance
Authors: R.C. Xing, J. Zheng, W.H. Zheng, Z.P. Qin, W. Liu and R.C. Yao
We examined the effect of E-cadherin expression on epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) molecular targeted therapy sensitivity/resistance. We treated MCF-7, MDA-MB-231, T24, SiHa, H460, SK-HEP-1, MHCC97-H, and THP- 1 cells with the EGFR-TKIs PD153035 and gefitinib, and then tested the drug-resistance and sensitivity using .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.29.10
- DOI:
- 10.4238/2015.May.29.10
Growth hormone polymorphisms and growth traits in Chinese Tibetan sheep Ovis aries
Authors: Y.C. Han, Y.G. Sun and Q. Li
Growth hormone (GH) plays an important role in promoting growth, protein and muscle accretion, and fat catabolism, suggesting that GH is a potential candidate gene affecting growth traits in vertebrates. In this paper, polymorphisms in GH were investigated in 632 Chinese Tibetan sheep, by using DNA sequencing. Three single nucleotide polymorphisms were id.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038397
- DOI:
- 10.4238/gmr.15038397