Growth
Effects of NELL2 on the regulation of GnRH expression and puberty in female rats
Authors: S.S. Zhou and P. Li
Neural tissue-specific epidermal growth factor-like repeat domain-containing protein (NELL2) was previously found to play an important role in nerve growth, neural differentiation, neural elasticity, synaptic transport, and vesicle release. In this study, we examined the effect of NELL2 on gonadotropin-releasing hormone (GnRH).. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.28.12
- DOI:
- 10.4238/2014.August.28.12
Efficient delivery of connective tissue growth factor shRNA using PAMAM nanoparticles
Authors: Z.J. Huang, B. Yi, H. Yuan and G.P. Yang
The aim of this study was to detect the anti-fibrosis activity of connective tissue growth factor (CTGF) small hairpin RNA (shRNA) mediated by polyamidoamine dendrimer nanoparticles in rat myocardial cell lines and myocardium. CTGF shRNAs were constructed from inverted oligonucleotides and a polyamidoamine nanoparticle vector .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.28.15
- DOI:
- 10.4238/2014.August.28.15
Association analysis of IGF-I gene expression with growth and reproductive traits in Jinghai yellow chickens
Authors: M.A. Abdalhag, T. Li, L. Duan, T. Zhang, G. Zhang, J. Wang and Y. Wang
The insulin-like growth factor, IGF-I, plays an important role in the development of growth and reproductive traits. Single-strand conformation polymorphism analysis was used to detect and analyze polymorphisms and expression profiles of the IGF-I gene and its association with growth and reproductive traits of Jinghai yellow c.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049205
- DOI:
- 10.4238/gmr15049205
Role of glutathione and other antioxidants in the inhibition of apoptosis and mesenchymal transition in rabbit lens epithelial cells
Authors: H.J. Wang, J. Zhu and G.Y. Zheng
This study aimed to discuss the effect and mechanism of glutathione (GSH) and catalase (CAT) on transforming growth factor beta (TGF-β)-induced lens epithelial cell (LEC) apoptosis and epithelial mesenchymal transition (EMT) to prevent and control cataracts. Healthy rabbits (4 weeks old) were randomly selected, and LECs f.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.1.1
- DOI:
- 10.4238/2014.September.1.1
Association of polymorphisms in growth hormone and leptin candidate genes with live weight traits of Brahman cattle
Authors: N. HernÃ?¡ndez, J.C. MartÃ?Ânez-GonzÃ?¡lez, G.M. Parra-Bracamonte, A.M. Sifuentes-RincÃ?³n, N. LÃ?³pez-Villalobos, S.T. Morris, F. Briones-Encinia, E. Ortega-Rivas, V.I. Pacheco-Contreras and L.A. Meza-GarcÃ?Âa
Polymorphisms in candidate genes can produce significant and favorable changes in the phenotype, and therefore are useful for the identification of the best combination of favorable variantsfor marker-assisted selection. In the present study, an assessment to evaluate the effect of 11 single nucleotide polymorphisms (SNPs) in .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038449
- DOI:
- 10.4238/gmr.15038449
Study of the correlation between GH gene polymorphism and growth traits in sheep
Authors: J.L. Jia, L.P. Zhang, J.P. Wu, Z.J. Ha and W.W. Li
The growth hormone gene plays an important role in the physiological function of an organism. The current study aimed to investigate the correlation between polymorphisms in the 5êÂ?Â? regulatory region, exon 4, and 3êÂ?Â? untranslated region (UTR) of the sheep GH gene and sheep growth traits. The DNA from 510 adult sheep wa.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.5.5
- DOI:
- 10.4238/2014.September.5.5
Association between the epidermal growth factor gene polymorphism and endometriosis in women from Brazil
Authors: C.B.N. Oliveira, P. Falagan-Lotsch, M.G. Souza, R.P. Santos, F. Encinas, H. Teles, R.B. Lasmar, L.B. Duarte, J.M. Granjeiro and I.A. Penna
The aim of this study was to verify the association between the epidermal growth factor (EGF) +61 G/A polymorphism and the susceptibility to endometriosis using a case-control design study. The control group included fertile women without endometriosis and the case group included endometriosis patients. Polymerase chain reacti.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.5.8
- DOI:
- 10.4238/2014.September.5.8
Construction and identification of pIRES2-VEGF165-NT-3 bicistronic eukaryotic expression vector
Authors: B.N. Li, W.D. Li, H.G. Feng, J.T. Lin and Z.Q. Yuan
We used a simple and efficient method to construct the bicistronic eukaryotic expression vector pIRES2-VEGF165-NT-3. The neurotrophin-3 (NT-3) gene was obtained from the genomic DNA of human peripheral blood mononuclear cells by polymerase chain reaction. The NT-3 cDNA fragment was cloned into the pIRES2-VEGF165-EGFP vector in.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.June.18.13
- DOI:
- 10.4238/2014.June.18.13
Effects of polymorphisms in the bovine growth differentiation factor 9 gene on sperm quality in Holstein bulls
Authors: K.Q. Tang, W.C. Yang, X.X. Zhang and L.G. Yang
Members of the transforming growth factor-β (TGFβ) superfamily are critical regulators of germ cell development that act as extracellular ligands of the signal transduction pathways regulating proliferation, differentiation, apoptosis, and other aspects of cell behavior. Growth differentiation factor 9 (GDF9) is a member of the TGFβ superfa.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.4.1
- DOI:
- 10.4238/2013.July.4.1
Association between VEGF and eNOS gene polymorphisms and lumbar disc degeneration in a young Korean population
Authors: I.B. Han, A.E. Ropper, Y.D. Teng, D.A. Shin, Y.J. Jeon, H.M. Park, D.E. Shin, Y.S. Park, K.N. Kim and N.-K. Kim
Disturbances in blood flow to intervertebral discs (IVD) play an important role in IVD degeneration. Vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS) are extremely important angiogenic factors for vasodilation and neovascularization. We investigated the relationship between single nucleotide polymorphisms (SNPs) of th.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.8.10
- DOI:
- 10.4238/2013.July.8.10