Growth
Polymorphisms of vascular endothelial growth factor on prognosis in hepatocellular carcinoma patients receiving transcatheter arterial chemoembolization treatment
Authors: J. Song, L.Z. Wang, X. Li, T.P. Jiang, T.Z. An, M. Xu, X.P. Wu and S. Zhou
We conducted a cohort study to investigate the prognostic significance of vascular endothelial growth factor (VEGF) polymorphisms in hepatocellular carcinoma (HCC) patients after transcatheter arterial chemoembolization (TACE). In total, 156 patients with histologically confirmed HCC within 2 months were collected from January 2007 to January 2008. The ge.. Read More»
- Genet. Mol. Res. 13(4):
Co-transfection of adeno-associated virus-mediated human vascular endothelial growth factor165 and transforming growth factor-�²1 into annulus fibrosus cells of rabbit degenerative intervertebral discs
Authors: Y.M. Xi, Y.F. Dong, Z.J. Wang, Y. Liu, Z.Z. Diao and Y.G. Hu
Intervertebral disc degeneration is a common condition that may lead to low back pain and radiculopathy. Understanding the pathophysiology and cellular and molecular events of degenerative disc disease has resulted in the proposal of a gene therapy approach to halt and reverse disc degeneration. We explored the feasibility of reversing intervertebral disc.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.February.28.11
- DOI:
- 10.4238/2013.February.28.11
Dietary methionine effects on IGF-I and GHR mRNA expression in broilers
Authors: A.P. Del Vesco, E. Gasparino, A.R. Oliveira Neto, S.E.F. Guimar�£es, S.M.M. Marcato and D.M. Voltolini
This study aimed to evaluate liver and breast muscle insulin-like growth factor I (IGF-I) and growth hormone receptor (GHR) gene expression between broilers fed different methionine levels and sources. Broiler chicks were 22 to 42 days old, distributed in 5 treatments (control diet, DL1 - 0.08% DL-methionine, DL2 - 0.24% DL-methionine, MHA-FA1 - 0.11% met.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.10.2
- DOI:
- 10.4238/2013.December.10.2
Genetic polymorphisms of the IGF-II gene intron 8 coding region and its association with growth and carcass traits in yak
Authors: Y.F. Zeng, X.Z. Ding, S.R. Cheng and S.J. Yu
Insulin-like growth factor II (IGF-II) plays a key role in mammalian growth and is involved in stimulating fetal cell division, differentiation, and metabolic regulation. IGF-II is considered a candidate gene for genetic markers of growth and carcass traits. Therefore, in this study, the associations of single nucleotide polymorphisms (SNPs) in the IGF-II.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.11.11
- DOI:
- 10.4238/2013.December.11.11
Association of the IGF-1 rs35767 and rs972936 polymorphisms with the risk of osteoporosis in a Chinese postmenopausal female population
Authors: Y.K. Wei1, H.L. Ma2, Y.Z. Guo3, B.H. Yang1 and W.X. Pang3
The aim of our study was to conduct a case-control study in a Chinese postmenopausal population to evaluate the roles of the IGF-1 rs35767 and rs972936 polymorphisms on bone mineral density (BMD) levels and osteoporosis risk. A total of 272 consecutive postmenopausal women with a primary diagnosis of osteoporosis and 272 controls were enrolled in the stud.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.17
- DOI:
- 10.4238/2015.November.13.17
Vascular endothelial growth factor gene polymorphisms and psoriasis susceptibility: a meta-analysis
Authors: Y.H. Lee and G.G. Song
The aim of this study was to explore whether vascular endothelial growth factor (VEGF) polymorphisms confer susceptibility to psoriasis. Meta-analyses were conducted to examine the associations between the +405 C/G, -460 C/T, -1154 A/G, and -2578 A/C polymorphisms of VEGF and psoriasis using allele contrast and recessive, dominant, and addi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.3
- DOI:
- 10.4238/2015.November.18.3
Impact of common SNPs in VEGF gene on the susceptibility of osteosarcoma
Authors: G.L. Hu, G. Ma and J.H. Ming
We conducted a case-control study to assess the role of vascular endothelial growth factor (VEGF) -634G/C, +936C/T, and +1612G/A genetic variations in the development of osteosarcoma in a Chinese population. This hospital-based case-control study examined 130 patients with osteosarcoma and 130 age- and gender-matched healthy controls from March 2011 and M.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.19
- DOI:
- 10.4238/2015.November.18.19
Molecular characterization and expression patterns of insulin-like growth factor-binding protein genes in postnatal Nanjiang brown goats
Authors: S.Y. Zhan, L. Chen, L. Li, L.J. Wang, T. Zhong and H.P. Zhang
Insulin-like growth factor-binding proteins (IGFBPs) play a key role in modulating insulin-like growth factors (IGFs), and are considered candidate genes for growth traits in livestock. In this study, we identified the complete coding sequences of IGFBP-1 to -6 in the Nanjiang brown goat, and assessed gene tissue expression pa.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.16.22
- DOI:
- 10.4238/2015.October.16.22
Hypoxia induces dysregulation of local renin-angiotensin system in mouse Lewis lung carcinoma cells
Authors: L. Fan*, Y. Feng*, H.Y. Wan, L. Ni, Y.R. Qian, Y. Guo, Y. Xiang and Q.Y. Li
The renin-angiotensin system (RAS) influences cancer biology and is frequently dysregulated in malignancy. However, regulation of tumor local RAS remains poorly understood. Hypoxia is a hallmark of solid tumors and affects nearly every major aspect of cancer biology. Previous studies have shown that hypoxia can regulate RAS expression in somatic tissues a.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.12.19
- DOI:
- 10.4238/2014.December.12.19
Single nucleotide polymorphisms of Ã?Â?6-desaturase and Elovl5 segments and their associations with common carp (Cyprinus carpio) growth traits
Authors: H. Ren, J. Yu, P. Xu and Y. Tang
Highly unsaturated fatty acids (HUFAs) are crucial for the nutritional health, physiology, and reproduction of vertebrates. The Δ6-desaturase and Elovl5 elongase genes produce essential enzymes in the biosynthetic pathway of HUFAs. Single nucleotide polymorphism (SNP) analysis of genes functionally related to the growth traits of the common carp (Cy.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.4
- DOI:
- 10.4238/2015.October.21.4