Haplotype
Haplotypes of qGL3 and their roles in grain size regulation with GS3 alleles in rice
Authors: Y.D. Zhang1,2, Z. Zhu1, Q.Y. Zhao1,2, T. Chen1, S. Yao1, L.H. Zhou1, L. Zhao1,C.F. Zhao1 and C.L. Wang1,2
Grain size is an important trait that directly influences rice yield. The qGL3 and GS3 genes are two putative regulators that play a role in grain size determination. A single rare nucleotide substitution (C→A) at position 1092 in exon 10 of qGL3 might be responsible for variations in grain size. However, little is known about the haplotype variation.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017587
- DOI:
- 10.4238/gmr.15017587
Genetic association of UBE2B variants with susceptibility to male infertility in a Northeast Chinese population
Authors: Genetic association of UBE2B variants with susceptibility to male infertility in a Northeast Chinese population
The ubiquitin-conjugating enzyme 2B gene (UBE2B) is involved in the regular and symmetric organization of the fibrous sheath of sperm flagella. This study aimed to examine the relationship between single nucleotide polymorphisms (SNPs) in UBE2B and infertility in Northeast Chinese men. We carried out a polymerase chain reaction-restriction fragment length po.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.September.12.2
- DOI:
- 10.4238/2012.September.12.2
Relationship between polymorphisms in the proline dehydrogenase gene and schizophrenia risk
Authors: F. Ghasemvand, E. Omidinia, Z. Salehi and S. Rahmanzadeh
Previous studies have suggested that an association exists between the proline dehydrogenase gene (PRODH) and increased schizophrenia risk. We examined the prevalence of the PRODH 757C/T (Arg185Trp), 1766A/G (Gly521Arg), and 1852G/A (intronic mutation) polymorphisms in 175 patients with schizophrenia and 185 control subjects. .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.2.14
- DOI:
- 10.4238/2015.October.2.14
Analysis of genetic diversity of the heat shock protein 70 gene on the basis of abundant sequence polymorphisms in chicken breeds
Authors: J.K. Gan, L.Y. Jiang, L.N. Kong, X.Q. Zhang and Q.B. Luo
This study was designed to detect the sequence variation of the chicken heat shock protein 70 (HSP70) gene. A total of 102 individuals from 8 native Chinese breeds together with Dwarf White Chicken and Red Junglefowl were used to detect sequence variations. The coding regions of the chicken HSP70 gene from 102 individuals were cloned and sequenced. Thirty.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.6.1
- DOI:
- 10.4238/2015.March.6.1
Analysis of common MDR1 (ABCB1) gene C1236T and C3435T polymorphisms in Turkish patients with familial Mediterranean fever
Authors: A. R�¼stemoglu, G. Gumus-Akay, S. Yigit and T. Tasliyurt
The multidrug resistance (MDR1) gene encodes a P-glycoprotein that plays a key role in drug bioavailability and response to drugs in different human populations. More than 50 SNPs have been described for the MDR1 gene. Familial Mediterranean fever (FMF) is considered an autosomal recessive hereditary disease, associated with a.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.14.7
- DOI:
- 10.4238/2011.December.14.7
Methylenetetrahydrofolate reductase genotypes and haplotypes associated with susceptibility to colorectal cancer in an eastern Chinese Han population
Authors: H. Li, W.L. Xu, H.L. Shen, Q.Y. Chen, L.L. Hui, L.L. Long and X.L. Zhu
Methylenetetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. The two common functional polymorphisms of MTHFR, C677T and A1298C have been associated with several diseases, including cancer. We made a case-control study to analyze a po.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.14.8
- DOI:
- 10.4238/2011.December.14.8
TPH2 gene polymorphisms in the regulatory region are associated with paranoid schizophrenia in Northern Han Chinese
Authors: X.M. Xu, M. Ding, H. Pang and B.J. Wang
In the last years, serotonin (5-HT) has been related with the pathophysiology of several psychiatric disorders, including schizophrenia. Thus, genes related to the serotonergic (5-HTergic) system are good candidate genes for schizophrenia. The rate-limiting enzyme of 5-HT synthesis is tryptophan hydroxylase 2 (TPH2). Single nu.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.12.1
- DOI:
- http://dx.doi.org/10.4238/2014.March.12.1
Relationship between genetic polymorphisms in the DRD5 gene and paranoid schizophrenia in northern Han Chinese
Authors: Y. Zhao, M. Ding, H. Pang, X.M. Xu and B.J. Wang
Dopamine (DA) has been implicated in the pathophysiology of several psychiatric disorders, including schizophrenia. Thus, genes related to the dopaminergic (DAergic) system are good candidate genes for schizophrenia. One of receptors of the DA receptor system is dopamine receptor 5 (DRD5). Single nucleotide polymorphisms (SNPs.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.12.13
- DOI:
- http://dx.doi.org/10.4238/2014.March.12.13
Association between eNOS polymorphisms and risk of coronary artery disease in a Korean population: a meta-analysis
Authors: J.H. Sung, B.E. Lee2, J.O. Kim2, Y.J. Jeon2, S.H. Kim1, S.W. Lim, J.Y. Moon, D.H. Cha, O.J. Kim, I.J. Kim and N.K. Kim
Coronary artery disease (CAD), a multifactorial disease, is a common cause of mortality in humans. Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene (-786T>C, 4a4b, and 894G>T) have been previously associated with increased CAD risk. However, the sample size of this previous study was too small and limited to comprehensively define .. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Polymorphisms of the TIM-1 gene are associated with rheumatoid arthritis in the Chinese Hui minority ethnic population
Authors: J.R. Xu, Y. Yang, X.M. Liu, J.Y. Sun and Y.J. Wang
The T-cell immunoglobulin and mucin domain 1 (TIM-1) is known to be associated with susceptibility to rheumatoid arthritis (RA). We investigated the association of four single-nucleotide polymorphisms (SNPs) in the promoter region of the TIM-1 gene with susceptibility to RA in a Chinese Hui ethnic minority group. Using RFLP or.. Read More»
- Genet. Mol. Res. 11(1):
- http://dx.doi.org/2012.January.9.7
- DOI:
- http://dx.doi.org/10.4238/2012.January.9.7