Heart
Maternal MTHFR C677T polymorphism and congenital heart defect risk in the Chinese Han population: a meta-analysis
Authors: K.H. Chen, L.L. Chen, W.G. Li, Y. Fang and G.Y. Huang
Numerous studies have evaluated the association between the maternal C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene and congenital heart defect (CHD) risk in the Chinese Han population. However, the specific association is still controversial. Six separate studies with 1089 subjects in the Chinese Han population on the relation.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.4.8
- DOI:
- 10.4238/2013.December.4.8
Microdeletion on 17p11.2 in a Smith-Magenis syndrome patient with mental retardation and congenital heart defect: first report from China
Authors: C. Huang, Y.-F. Yang, H. Zhang, L. Xie, J.-L. Chen, J. Wang, Z.-P. Tan and H. Luo
Smith-Magenis syndrome (SMS) is a rare syndrome with multiple congenital malformations, including development and mental retardation, behavioral problems and a distinct facial appearance. SMS is caused by haploinsufficiency of RAI1 (deletion or mutation of RAI1). We describe an eight-year-old female Chinese patient with multiple malformations, congenital .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.13.5
- DOI:
- 10.4238/2012.August.13.5
Relationship between perioperative cardiovascular risk factors and bone marrow cells from patients undergoing coronary artery bypass grafting surgery
Authors: L. Zhang, R. Wang, C.-S. Xiao, Y. Wu and C.-Q. Gao
Cell therapy through the implantation of autologous bone marrow cells has long been used in clinical trials for the treatment of ischemic heart diseases. However, as the outcomes of cell implantation vary among patients, risk factors that might influence the level and function of bone marrow progenitor cells should be determin.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.25.11
- DOI:
- 10.4238/2015.November.25.11
Lack of an association between matrix metalloproteinase polymorphisms and coronary heart disease in a Han Chinese population
Authors: C.M. Wang, H.D. Ye, Y.R. Li, Q.X. Hong, L.L. Tang, A.N. Zhou, M.Q. Xu and S.W. Duan
Coronary heart disease (CHD) has become a leading cause of human deaths worldwide. Recent studied showed that polymorphisms of the matrix metalloproteinase (MMP) genes played important roles in extracellular matrix remodeling and contribute to the pathogenesis of vascular diseases. Here, we investigated whether these MMP gene .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.9.14
- DOI:
- 10.4238/2015.October.9.14
Significant interaction of APOE rs4420638 polymorphism with HDL-C and APOA-I levels in coronary heart disease in Han Chinese men
Authors: Y. Huang, H.D. Ye, X. Gao, S. Nie, Q.X. Hong, H.H. Ji, J. Sun, S.J. Zhou, B. Fei, K.Q. Li, J.K. Zhao, Z.P. Wang, M.Q. Xu and S.W. Duan
Apolipoprotein E (APOE) is recognized for its importance in lipoprotein metabolism and cardiovascular disease. We evaluated the association between APOE rs4420638 genotypes and circulating lipid concentrations along with the risk of coronary heart disease (CHD). We conducted a case-control study involving 1508 individuals to investigate the contribution o.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.3
- DOI:
- 10.4238/2015.October.28.3
Association between angiotensin-converting enzyme insertion/deletion polymorphisms and the risk of heart disease: an updated meta-analysis
Authors: F.J. You and D.M. Shen
Insertion/deletion (I/D) polymorphisms of the gene encoding angiotensin converting enzyme (ACE) are a controversial risk factor for heart diseases (HDs). ACE I/D polymorphism has been reported to be associated with various cardiovascular diseases. However, some studies have presented conflicting results. In this study, we aim to explore the association be.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017194
- DOI:
- 10.4238/gmr.15017194
Association of N-acetyltransferase-2 polymorphism with an increased risk of coronary heart disease in a Chinese population
Authors: J.D. Sun, H. Yuan, H.Q. Hu and H.M. Yu
We investigated the possible correlations between N-acetyltransferase-2 (NAT2) gene polymorphisms and the risk of coronary heart disease (CHD). CHD patients (113) and healthy controls (118) were enrolled from the First People’s Hospital of Yuhang between January 2013 and June 2014. The patients were divided into mild CHD (N = 72) and severe CHD (N =.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016954
- DOI:
- 10.4238/gmr.15016954
Effect of atorvastatin on plasma NT-proBNP and inflammatory cytokine expression in patients with heart failure
Authors: H.Y. Duan, D.M. Liu, P. Qian, S.L. Wang, L.J. Yan, J.T. Wu, H.T. Yang, X.W. Fan, Y.J. Chu
The aim of this study was to explore the effect of atorvastatin intervention on plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) and inflammatory cytokine levels in patients with heart failure (HF). One hundred and twenty-three HF patients were selected from our hospital and randomly divided into control (N = 61) a.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.25
- DOI:
- 10.4238/2015.December.1.25
Identification of molecular markers in patients with hypertensive heart disease accompanied with coronary artery disease
Authors: H. Pang, B. Han, Z.Y. Li and Q. Fu
We investigated the plasma hypersensitive C-reactive protein (hs-CRP), oxidized low-density lipoprotein (ox-LDL), and apelin levels in patients with hypertensive heart disease (HHD) plus coronary artery disease (CAD). Patients with hypertension hospitalized in Xuzhou Central Hospital were categorized into the HHD group and the HHD plus CAD group; 40 healt.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.12
- DOI:
- 10.4238/2015.January.15.12
Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure
Authors: X.S. Gu, Z.B. Wang, Z. Ye, J.P. Lei, L. Li, D.F. Su and X. Zheng
Reduced AMP-activated protein kinase (AMPK) expression has been shown to play a significant role in the cardiac dysfunction in heart failure. This study was designed to examine the effect of resveratrol, a potent activator of silent information regulator (SIRT1), on cardiac function and AMPK expression in heart failure. Adult .. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.January.17.17
- DOI:
- http://dx.doi.org/10.4238/2014.January.17.17