Heart
A66G and C524T polymorphisms of the methionine synthase reductase gene are associated with congenital heart defects in the Chinese Han population
Authors: W. Zeng, L. Liu, Y. Tong, H.M. Liu, L. Dai and M. Mao
Congenital heart defects (CHDs) are the most common birth defects; genes involved in homocysteine/folate metabolism may play important roles in CHDs. Methionine synthase reductase (MTRR) is one of the key regulatory enzymes involved in the metabolic pathway of homocysteine. We investigated whether two polymorphisms (A66G and C.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.25.7
- DOI:
- 10.4238/2011.October.25.7
Correlation between polymorphisms in the estrogen receptor �± gene and coronary heart disease: A meta-analysis
Authors: W. Zhou, K.H. He and M.H. Chen
The aim of this study was to conduct a systematic evaluation the correlation between polymorphisms in the estrogen receptor α gene (ESRα) and coronary heart disease susceptibility. Case-control studies until August 2015 analyzing the correlation between the ESRα PvuII T/C polymorphism and coronary heart disease were obtained from various.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037835
- DOI:
- 10.4238/gmr.15037835
Relationship between serum adiponectin and osteoprotegerin levels and coronary heart disease severity
Authors: H.L. Zhang and X. Jin
This study aimed to explore serum adiponectin and osteoprotegerin levels in patients with coronary heart disease (CHD) and their correlation with inflammatory and ischemia factors. From September 2010 to Augest 2010, 347 CHD patients were enrolled for a retrospective analysis. Serum lipoprotein phospholipase A2 (Lp-PLA2), hypersensitive C-reactive protein.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.21.15
- DOI:
- http://dx.doi.org/10.4238/2015.September.21.15
Relationship of polymorphisms in the cholesteryl ester transport protein gene R451Q with coronary heart disease and diabetes in Uyghur and Han Chinese
Authors: C.J. Zhang, H.M. Qiu and J.P. Qiu
To investigate the relationship of polymorphisms in the cholesteryl ester transport protein (CETP) gene with coronary heart disease (CHD) and diabetes in subjects of Uyghur and Han Chinese origin, 266 subjects with CHD including 154 subjects with type 2 diabetes mellitus and 136 healthy subjects (as a control group) were enrol.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.February.19.6
- DOI:
- 10.4238/2014.February.19.6
Novel NKX2-5 mutations responsible for congenital heart disease
Authors: J. Wang, X.Y. Liu and Y.Q. Yang
Congenital heart disease (CHD) is the most common birth defect and is the leading cause of infant morbidity and mortality resulting from birth defects. Increasing evidence demonstrates that genetic variation in the NKX2-5 gene, which encodes a homeobox-containing transcription factor crucial to cardiogenesis, is an important m.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.November.29.1
- DOI:
- 10.4238/2011.November.29.1
Diversity of platelet function and genetic polymorphism in clopidogrel-treated Chinese patients
Authors: B. Sun, J. Li, M. Dong, L. Yang, C. Wu, L. Zhu and Y.L. Cong
We investigated the correlation between genetic polymorphisms of cytochrome P450 enzyme genes and the outcome of clopidogrel treatment in 118 coronary disease patients after percutaneous coronary intervention at the Chinese PLA General Hospital. Patients were divided into an ischemia event relapse group (IERG) and a non-IERG group (NIERG) based on relapse.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.22
- DOI:
- 10.4238/2015.February.13.22
Male-specific association of the APC rs383830 T allele with the risk of coronary heart disease
Authors: J.Y. Zhong, X.W. Zheng, H.D. Ye, H.B. Cui, W.P. Du, Z.X. Zhang, X.H. Fei, S.Y. Lin, J. Wang, J. Su, X.M. Chen and S.W. Duan
APC is a tumor suppressor gene that is involved in the processes of cell migration and adhesion, transcriptional activation, and apoptosis. The goal of this study was to evaluate the contribution of the APC rs383830 polymorphism to coronary heart disease (CHD) in Han Chinese. A total of 783 patients with CHD and 737 controls w.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.2.8
- DOI:
- 10.4238/2015.October.2.8
Clinical observation of umbilical cord mesenchymal stem cell treatment of severe systolic heart failure
Authors: X.F. Zhao, Y. Xu, Z.Y. Zhu, C.Y. Gao and Y.N. Shi
The aim of this study was to evaluate the effectiveness of umbilical cord mesenchymal stem cells (MSCs) in the treatment of chronic systolic heart failure. Fifty-nine hospitalized patients with heart failure were randomly divided into a treatment group (30 patients) and a control group (29 patients). The treatment group received treatment with medication .. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.11
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.11
Genetic variations of ISL1 associated with human congenital heart disease in Chinese Han people.
Authors: Z.L. Luo, H. Sun, Z.Q. Yang, Y.H. Ma, Y. Gu, Y.Q. He, D. Wei4, L.B. Xia, B.H. Yang and T. Guo
Congenital heart disease (CHD) is the most common birth abnormality, but the etiology of CHD is unknown. ISL1 may play a fundamental role in cardiac morphogenesis, and mutations of this gene could cause CHD. To evaluate whether genetic variations of ISL1 are associated with CHD in Chinese Han people, polymerase chain reaction .. Read More»
- Genet. Mol. Res. 13(1):
Association of miR-196a2, miR-27a, and miR-499 polymorphisms with isolated congenital heart disease in a Chinese population
Authors: K. Yu, Y. Ji, H. Wang, Q.K. Xuan, B.B. Li, J.J. Xiao, W. Sun and X.Q. Kong
We hypothesized that single nucleotide polymorphisms (SNPs) in certain microRNAs contribute to congenital heart disease (CHD) phenotypes. Five hundred and seventy-three subjects were enrolled in this study. DNA extracted from peripheral blood cells was used for SNP genotyping of miR-196a2 (rs11614913), miR-27a (rs11671784, rs8.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048929
- DOI:
- 10.4238/gmr15048929